A prevascularized nerve conduit based on a stem cell sheet effectively promotes the repair of transected spinal cord injury

Peptide OM-LV20 promotes structural and functional recovery of spinal cord injury in rats

“…Here, we chose the complete spinal cord transected injury model 25 . Although this model exhibits high mortality and di culty in nursing, it is one of the most effective models for SCI, and has great value in verifying dynamic changes in the microenvironment at the site of injury and restoration of spinal cord structure and function 26 .…”

Microcomputed analysis of nerve angioarchitecture after combined stem cell delivery and surgical angiogenesis to nerve allograft

“…With different experimental designs, it is difficult to compare our results at two weeks to their 16 week outcomes 27 . The synergistic effect of stem cells and surgical angiogenesis is hypothesized to be due to the adipofascial flap providing vascular delivery of trophic factors, sufficient nutrients and oxygen, resulting in less hypoxia vital to sustaining survivability of stem cells 28,29 . Stem cells have a neuroprotective and immunomodulatory effect causing less fibrosis and scarring, subsequently resulting in improved diffusion to meet the demands of cellular metabolism 24,30,31 .…”

Advances in Biomaterial‐Based Spinal Cord Injury Repair

“…When compared to the nonprevascularized nerve conduit, the prevascularized nerve conduit based on MSC cell sheets efficiently accelerated SCI healing by improving the conditions of ischemia and hypoxia. [165] Vascularized scaffolds can also reduce inflammation and glial scar formation. [164][165]…”