A Preventative Strategy for Autosomal Dominant Polycystic Kidney Disease: Economic and Policy Aspects

Primary prevention of hereditary disease and the economic sustainability of public health systems go hand in hand

“…We present our study carried out in ADPKD individuals where the preventive strategy using Preimplantation Genetic Testing (PGT) is compared with the current panorama of arrival on RRT (Figure 1). 3 For this, a simulated design was used, applying the health intervention of the PGT in couples with one of its affected members, and the measure of effectiveness used was the live births per transfer rate (LBTR). This study arose as a consequence of the need to assess the economic impact of the implementation of the non-legal proposal (10-16/PNLC-000248) approved in 2016 in the Andalusian Parliament regarding the creation of the Primary Prevention Plan for ADPKD, which in its point 5 urged the Government of the Junta de Andalucía to promote the most appropriate reproductive options that would prevent the transmission of the disease and specifically the PGT.…”

“…Given the good results obtained, this strategy was recommended to the health authorities of the Andalusian Public Health System (APHS) through the Preventive Project of ADPKD, and in 2022 PGT was authorized in Granada and the first girl free of disease from an ADPKD mother through PGT has already been born in the PHS. [6][7][8] Figure 1 Comparative cost-effectiveness analysis of two health management strategies for autosomal dominant polycystic kidney disease (ADPKD): current vs. preventive intervention with PGT 1 Primary prevention of hereditary disease and the economic sustainability of public health systems go hand in hand Volume 11 Issue 2 -2023 Rafael José Esteban de la Rosa, 1,2,3,4 José Luis Navarro Espigares, 8,9 Ana I Morales García, 2,4,6 Luis Martínez Navarro, 2,7 Antonio Miguel Poyatos Andújar, 2,5 María García Valverde, 1,2,3 Juan Antonio Bravo Soto…”