A Preventive Cytokine Treatment of the Viral Infectious Bursal Disease (IBD) of Chickens

Abstract

Infectious bursal disease (IBD) is a viral disease of young chickens that produce severe lesions in the bursa of Fabricius and other organs inducing immunosuppression and mortality in birds. This study indicates that oral administration of IFN-α and IL-2 during 16 days produced a significant reduction in animals' morbidity and mortality to IBD virus (IBDV) infection accompanied with a decrease in symptoms and bursal tissue damage. The treatment also increased body weight, not only in birds challenged with IBDV, but also in uninfected controls. Infected birds treated with cytokines presented the same bursal index and organs' weight that controls; since untreated animals showed a significant decrease in these parameters. Finally, cytokine administration represents a new alternative to IBDV vaccination.

Decreased levels of kynurenic acid in prefrontal cortex in a genetic animal model of depression

“…Depression often occurs together with other diseases, such as atherosclerosis, rheumatoid arthritis and congestive heart failure, all involving chronic inflammatory factors (Evans et al, 2005). Cytokine immunotherapy is a useful treatment strategy for some specific cancer and viral diseases (Ardolino et al, 2015;Mattiello et al, 2015). Patients with cancer or hepatitis C receiving cytokine immunotherapy frequently generate depressive symptoms (Capuron and Dantzer, 2003;Capuron et al, 2002).…”