A previous abrasion in the contralateral eye influences the cell kinetics during healing of a central corneal abrasion

Estil, Svein; Haaskjold, Erling; Bjerknes, Rolf; Refsum, Sigvald

doi:10.1034/j.1600-0420.2001.079004389.x

Cited by 6 publications

(4 citation statements)

References 14 publications

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“…Estil et al also showed that a previous corneal erosion in the fellow eye resulted in faster healing of the second eye, and explained that this corneal healing process was influenced by systemic factor(s). [ 10 ] Our data are consistent with those studies and further demonstrated that this systemic effect may influence the early phase of the fellow eye’s wound healing, which corresponds to the inflammatory phase. [ 20 ]…”

Section: Discussionsupporting

confidence: 92%

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Difference in Outcomes between First-Operated vs. Fellow-Operated Eyes in Patients Undergoing Bilateral Trabeculectomies

et al. 2015

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Main ObjectiveTo compare the course and outcome of first- and fellow-operated eyes in patients who underwent bilateral trabeculectomies and to investigate the factors associated with the difference.MethodsPreoperative characteristics, including the interval between surgeries, were compared between the first- and fellow-operated eyes in 42 patients who underwent bilateral trabeculectomies. Postoperative intraocular pressure and bleb vascularity, using postoperative anterior segment photos, were compared at various time points between the first- and fellow-operated eyes. Surgical success was evaluated at 1 year after surgery and at the final follow-up. Factors affecting the difference between the first and fellow eyes were analyzed.ResultsThere was no significant difference in success or failure rates at 1 year postoperatively and at the final follow-up between the first- and fellow-operated eyes. Early postoperative IOP and the degree of bleb vascularity were higher in the fellow-operated eyes (P = 0.001 and 0.003, respectively at week 1 postoperative). The difference in IOP between the first- and fellow-operated eyes was greater in patients whose interval between surgeries was shorter than 3 weeks (P = 0.026).ConclusionsIn patients undergoing bilateral trabeculectomies, early postoperative IOP was higher in the fellow-operated eyes than the first-operated eyes; the difference was greater when the interval between surgeries was shorter. The first-operated eye may influence the early postoperative inflammatory response in the fellow-operated eye. Our findings have clinical implications for planning treatment of patients who may need bilateral surgery.

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Section: Discussionsupporting

confidence: 92%

“…[ 9 ] Another study suggested that the corneal abrasion of the first eye affected the healing process of the corneal epithelium of the fellow eye by increasing cell proliferation. [ 10 ]…”

Section: Introductionmentioning

confidence: 99%

Difference in Outcomes between First-Operated vs. Fellow-Operated Eyes in Patients Undergoing Bilateral Trabeculectomies

et al. 2015

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“…Taken together, the data indicate that the manipulation of one cornea with a contact lens affects the proliferation rate on the non-lens-wearing, contralateral cornea. Estil et al 39 have reported a similar cross talk reaction during wound healing. Inducing a wound in one cornea caused an increase in cell proliferation in the contralateral control cornea.…”

Section: Discussionmentioning

confidence: 77%

Effects of Eyelid Closure and Disposable and Silicone Hydrogel Extended Contact Lens Wear on Rabbit Corneal Epithelial Proliferation

Ladage

Ren

Petroll

et al. 2003

Invest. Ophthalmol. Vis. Sci.

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Short-term overnight SH, DH, and SUT all significantly suppressed the cell proliferation rate in the rabbit corneal epithelium. However, adaptation, with central hyperproliferation of cells, appeared to occur at 8 days. The effects of lens wear and eyelid suturing on the cell proliferation rate in contralateral control eyes suggests a central mechanism that regulates corneal epithelial proliferation.

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“…Fonn et al 28 found that the corneal thickness was significantly different between the control eyes of patients wearing unilaterally a high-oxygen-transmissible lens compared with the control eyes with the low-oxygen-transmissible lens. Furthermore, inducing a wound in one cornea resulted in an upregulation of proliferation in the contralateral control cornea, 29 and even tear film osmolality in the contralateral control eye can be affected after monocular soft lens wear. 30 Thus, corneal epithelial homeostasis in both eyes appears to be linked systemically through mechanism(s) that remain to be established.…”

Section: Discussionmentioning

confidence: 99%

Vertical Movement of Epithelial Basal Cells toward the Corneal Surface during Use of Extended-Wear Contact Lenses

Ladage

Jester

Petroll

et al. 2003

Invest. Ophthalmol. Vis. Sci.

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Within 6 days, the majority (80%) of BrdU-labeled basal cells became terminally differentiated and rarely divided secondarily in the central epithelium. Short-term use of low- and medium-Dk/t RGP EW contact lenses slows the normal movement of basal epithelial cells toward the surface in the central cornea. This is consistent with known EW-lens-induced decreases in corneal epithelial basal cell proliferation and surface cell exfoliation. Overall, the data suggest that EW lenses significantly inhibit the normal homeostatic turnover rate of the corneal epithelium.

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A previous abrasion in the contralateral eye influences the cell kinetics during healing of a central corneal abrasion

Abstract: ABSTRACT.Purpose: To study the influence of a previous erosion in the fellow eye on the proliferative response during healing of a central corneal erosion.

Cited by 6 publications

References 14 publications

Difference in Outcomes between First-Operated vs. Fellow-Operated Eyes in Patients Undergoing Bilateral Trabeculectomies

Difference in Outcomes between First-Operated vs. Fellow-Operated Eyes in Patients Undergoing Bilateral Trabeculectomies

Effects of Eyelid Closure and Disposable and Silicone Hydrogel Extended Contact Lens Wear on Rabbit Corneal Epithelial Proliferation

Vertical Movement of Epithelial Basal Cells toward the Corneal Surface during Use of Extended-Wear Contact Lenses

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