A previously unclassified trypanosomatid responsible for human cutaneous lesions in Martinique (French West Indies) is the most divergent member of the genus <i>Leishmania ss </i>

Noyes, H. A.; Pratlong, Francine; Chance, Michaël La; Ellis, John; Lanotte, G.; Dedet, Jean-Pierre

doi:10.1017/s0031182001008927

Cited by 64 publications

(60 citation statements)

References 11 publications

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“…E-mail: vigniernicolas@yahoo.fr examination of skin smears and consisted of localized CL in immunocompetent patients, except for one case of diffuse CL in an HIV-infected patient. 3,4 More recently, seven additional CL cases (six of them were unpublished) were found to be caused by a new Leishmania species. None of these cases presented visceral dissemination.…”

Section: Discussionmentioning

confidence: 99%

“…This parasite was identified by both molecular and isoenzymatic techniques and found to be a member of the Leishmania subgenus at the base of the phylogenetic tree. 4 The new Leishmania taxon was recently described and named L. (L.) martiniquensis n. sp. 5 Capacity of visceralization and dissemination has been shown in a murine model.…”

Section: Discussionmentioning

confidence: 99%

“…7 The molecular identification based on the ribosomal 18S RNA locus analysis gave a 100% identity with the sequence of the MHOM/MQ/92/MAR1 strain (GenBank accession number AF303938.1), a divergent Leishmania strain described for the first time in Martinique in 1995 and recently named L. martiniquensis. 4,5 A retrospective analysis of several sera from our patient stored since 2007 detected high levels of antileishmanial antibodies by indirect immunofluorescence assay (IFA) and enzyme-linked immunosorbent assay (ELISA) using L. infantum antigen (Table 1). Immunoblot revealed two specific bands of 14 and 16 kDa, confirming the specificity of these antibodies.…”

Section: Case Reportmentioning

confidence: 99%

“…was first isolated in 1995; its taxonomical position was established in 2002, and it was named in 2014. [3][4][5] This species is up to now restricted to Martinique and has been only reported in patients with cutaneous lesions. We report the first case of VL caused by this parasite in an immunocompromised HIVinfected patient.…”

Section: Introductionmentioning

confidence: 99%

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First Case of Visceral Leishmaniasis Caused by Leishmania martiniquensis

Liautaud¹,

Vignier²,

Miossec³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. We report the first case of visceral leishmaniasis (VL) caused by Leishmania martiniquensis in the Caribbean, which until now, was known only to cause cutaneous leishmaniasis. The disease presented with fatigue, anemia, and hepatosplenomegaly in a 61-year-old man with human immunodeficiency virus (HIV) infection who was receiving antiretroviral therapy. Diagnosis was made by bone marrow biopsy. VL is life-threatening, and its emergence in the Caribbean is of concern.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

First Case of Visceral Leishmaniasis Caused by Leishmania martiniquensis

Liautaud¹,

Vignier²,

Miossec³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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“…Leishmania martiniquensis is a species originally reported from Martinique Island 11 in an HIV-infected patient with diffused nodular CL in 1995. 12 Other molecular typings of three target genes of L. martiniquensis (MHOM/MQ/92/ MAR1) and the GenBank accession numbers are as follows: RNA polymerase (AF326982), DNA polymerase (AF326983), 13 and 18S-rRNA (AF303938).…”

Section: Species Identification Of Leishmania (Leishmania)mentioning

confidence: 99%

Leishmaniasis in Thailand: A Review of Causative Agents and Situations

Leelayoova

Siripattanapipong

Manomat

et al. 2017

The American Society of Tropical Medicine and Hygiene

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Abstract. Before 1999, leishmaniasis was considered an imported disease in Thailand. Since then, autochthonous leishmaniasis was reported in both immmunocompetent and immmunocompromised patients especially in human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). A new species was identified and named as Leishmania siamensis consisting of two lineages, that is, lineages TR and PG. Analysis of isoenzymes has clarified the more commonly detected L. siamensis lineage PG as Leishmania martiniquensis (MON-229), a species originally reported from the Martinique Island, whereas the L. siamensis lineage TR has been identified as the true novel species, L. siamensis (MON-324). Both cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL) have been found among Thai patients. Disseminated CL and VL could be presented in some reported patients who had HIV/AIDS coinfection. So far, only sporadic cases have been reported; thus, the true prevalence of leishmaniasis should be determined in Thailand among the high-risk populations such as people with HIV/AIDS. A recent survey among animals identified L. martiniquensis DNA in black rats (Rattus rattus) suggesting a potential animal reservoir. In addition, L. martiniquensis DNA was identified in Sergentomyia gemmea and Sergentomyia barraudi, the predominant sandfly species in the affected areas. However, further studies are needed to prove that these sandflies could serve as the vector of leishmaniasis in Thailand.

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Nanodiagnostics in leishmaniasis: A new frontiers for early elimination

Gedda

Madhukar

Shukla

et al. 2020

WIREs Nanomed Nanobiotechnol

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Visceral leishmaniasis (VL) is still a major public health concern in developing countries having the highest outbreak and mortality potential. While the treatment of VL has greatly improved in recent times, the current diagnostic tools are limited for use in the post‐elimination setting. Although conventional serological methods of detection are rapid, they can only differentiate between active disease in strict combination with clinical criteria, and thus are not sufficient enough to diagnose relapse patients. Therefore, there is a dire need for a portable, authentic, and reliable assay that does not require large space, specialized instrument facilities, or highly trained laboratory personnel and can be carried out in primary health care settings. Advances in the nanodiagnostic approaches have led to the expansion of new frontiers in the concerned area. The nanosized particles are blessed with an ability to interact one‐on‐one with the biomolecules because of their unique optical and physicochemical properties and high surface area to volume ratio. Biomolecular detection systems based on nanoparticles (NPs) are cost‐effective, rapid, nongel, non‐PCR, and nonculture based that provide fast, one‐step, and reliable results with acceptable sensitivity and specificity. In this review, we discuss different NPs that are being used for the identification of molecular markers and other biomarkers, such as toxins and antigens associated with leishmaniasis. The most promising diagnostic approaches have been included in the article, and the ability of biomolecular recognition, advantages, and disadvantages have been discussed in detail to showcase the enormous potential of nanodiagnostics in human and veterinary medicine. This article is categorized under: Diagnostic Tools > Diagnostic Nanodevices Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Diagnostic Tools > Biosensing

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A previously unclassified trypanosomatid responsible for human cutaneous lesions in Martinique (French West Indies) is the most divergent member of the genus Leishmania ss

Cited by 64 publications

References 11 publications

First Case of Visceral Leishmaniasis Caused by Leishmania martiniquensis

First Case of Visceral Leishmaniasis Caused by Leishmania martiniquensis

Leishmaniasis in Thailand: A Review of Causative Agents and Situations

Nanodiagnostics in leishmaniasis: A new frontiers for early elimination

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