A series of bismo-borate (50-x)B 2 O 3 -xTiO 2 -15Na 2 O-30Bi 2 O 3 glass samples (where x = 0, 2.5, 5, 7.5, and 10 wt %) doped with TiO 2 were fabricated via the melt-quenching technique. The gamma and neutron shielding, physical, optical, and mechanical properties of the prepared samples were investigated. The experimental results were measured using an HPGe detector. 152 Eu, 133 Ba, 137 Cs, and 60 Co radioactive sources were used with energies in the range of 81-1408 keV. The experimental results were compared with both the FLUKA code and the XCOM database. The addition of TiO 2 increased the density of the glass samples and decreased their molar volume. The mass attenuation coefficient (MAC) decreased as photon energy decreased, while it increased as TiO 2 concentration increased. The half value layer (HVL) and mean free path (MFP) of the glass samples increased when the photon energy increased and decreased as the TiO2 concentration increased. The absorbance of the present samples is enhanced by using TiO 2 , meaning they can be used to protect humans from UV light. Both direct and indirect band gaps decreased as TiO 2 content increased from 0 to 10 wt %. Moreover, the electronic transition between localized states is valid in the present samples. The radiation shielding, optical, physical, and mechanical properties of the fabricated glass samples demonstrate their utility for diagnostic gamma shielding.