A primer on cytokines

Chauhan, Prashant; Nair, Arathi; Patidar, Ashok; Dandapat, Jagneshwar; Sarkar, Arup; Saha, Bhaskar

doi:10.1016/j.cyto.2021.155458

Cited by 49 publications

(49 citation statements)

References 252 publications

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“…In human fibrosarcoma-derived cell line, INF-gamma induces expression of Smad7 mediated by phosphorylation and activation of the transcription factor STAT1 through JAK1 thereby preventing the interaction of Smad3 with TGF-β receptor ( Majoros et al, 2017 ). Signal-transduction pathways induced by JAK/STAT and TGF-β signaling may be affected by transmodulating interactions between Smads and STATs ( Chauhan et al, 2021 ). In conclusion, apart from regulating T-lymphocyte activation, TGF-β cross connects with JAK/STAT signaling to regulate plethora of pathophysiological process via Smads which includes activation of hematopoiesis, TGF-β fibrogenic responses in hepatic stellate cells, transcription of genes regulating EMT and regulating pluropotency and differentiations of cells ( Figure 7 ).…”

Section: Introductionmentioning

confidence: 99%

Transforming Growth Factor-Beta (TGF-β) Signaling in Cancer-A Betrayal Within

et al. 2022

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A ubiquitously expressed cytokine, transforming growth factor-beta (TGF-β) plays a significant role in various ongoing cellular mechanisms. The gain or loss-of-function of TGF-β and its downstream mediators could lead to a plethora of diseases includes tumorigenesis. Specifically, at the early onset of malignancy TGF-β act as tumour suppressor and plays a key role in clearing malignant cells by reducing the cellular proliferation and differentiation thus triggers the process of apoptosis. Subsequently, TGF-β at an advanced stage of malignancy promotes tumorigenesis by augmenting cellular transformation, epithelial-mesenchymal-transition invasion, and metastasis. Besides playing the dual roles, depending upon the stage of malignancy, TGF-β also regulates cell fate through immune and stroma components. This oscillatory role of TGF-β to fight against cancer or act as a traitor to collaborate and crosstalk with other tumorigenic signaling pathways and its betrayal within the cell depends upon the cellular context. Therefore, the current review highlights and understands the dual role of TGF-β under different cellular conditions and its crosstalk with other signaling pathways in modulating cell fate.

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Section: Introductionmentioning

confidence: 99%

Transforming Growth Factor-Beta (TGF-β) Signaling in Cancer-A Betrayal Within

et al. 2022

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“…This feature is driven through helpful and effective mutations within these genes, which may lead to a coevolutionary adaptation in host-pathogen interactions. In this regard, the results of a survey showed that out of 25 genes with highest evolutionary divergence in humans, seven genes belong to cytokines (e.g., ILs) [ 43 , 66 ]. Interestingly, despite the occurrence of evolutionary divergence among cytokine genes (such as IL genes), some structural resemblance can still be seen.…”

Section: Genomics Of Ilsmentioning

confidence: 99%

The Interleukin-1 (IL-1) Superfamily Cytokines and Their Single Nucleotide Polymorphisms (SNPs)

Behzadi

Sameer

Nissar

et al. 2022

Journal of Immunology Research

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Interleukins (ILs)—which are important members of cytokines—consist of a vast group of molecules, including a wide range of immune mediators that contribute to the immunological responses of many cells and tissues. ILs are immune-glycoproteins, which directly contribute to the growth, activation, adhesion, differentiation, migration, proliferation, and maturation of immune cells; and subsequently, they are involved in the pro and anti-inflammatory responses of the body, by their interaction with a wide range of receptors. Due to the importance of immune system in different organisms, the genes belonging to immune elements, such as ILs, have been studied vigorously. The results of recent investigations showed that the genes pertaining to the immune system undergo progressive evolution with a constant rate. The occurrence of any mutation or polymorphism in IL genes may result in substantial changes in their biology and function and may be associated with a wide range of diseases and disorders. Among these abnormalities, single nucleotide polymorphisms (SNPs) can represent as important disruptive factors. The present review aims at concisely summarizing the current knowledge available on the occurrence, properties, role, and biological consequences of SNPs within the IL-1 family members.

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“…The sharing of cytokine receptor chains and signalling pathways provides a mechanism for functional redundancy. The existence of more than one receptor for that cytokine can explain the pleiotropic effects of a single cytokine [8], while the expression and distribution of cytokine receptors among the different cell types determine the specificity of cytokine activity [9]. The combinatorial array of cell type-specific and context-specific expression of cytokines and receptor complexes is responsible for various host protective immunity, organ development and metabolism, haematopoiesis, tumorigenesis, development, and inflammation [10].…”

Section: Type I Cytokine Receptorsmentioning

confidence: 99%

CRLF1 and CLCF1 in Development, Health and Disease

Crisponi

Buers

Rutsch

2022

IJMS

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Cytokines and their receptors have a vital function in regulating various processes such as immune function, inflammation, haematopoiesis, cell growth and differentiation. The interaction between a cytokine and its specific receptor triggers intracellular signalling cascades that lead to altered gene expression in the target cell and consequent changes in its proliferation, differentiation, or activation. In this review, we highlight the role of the soluble type I cytokine receptor CRLF1 (cytokine receptor-like factor-1) and the Interleukin (IL)-6 cytokine CLCF1 (cardiotrophin-like cytokine factor 1) during development in physiological and pathological conditions with particular emphasis on Crisponi/cold-induced sweating syndrome (CS/CISS) and discuss new insights, challenges and possibilities arising from recent studies.

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A primer on cytokines

Cited by 49 publications

References 252 publications

Transforming Growth Factor-Beta (TGF-β) Signaling in Cancer-A Betrayal Within

Transforming Growth Factor-Beta (TGF-β) Signaling in Cancer-A Betrayal Within

The Interleukin-1 (IL-1) Superfamily Cytokines and Their Single Nucleotide Polymorphisms (SNPs)

CRLF1 and CLCF1 in Development, Health and Disease

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