A primer on developing interleaved transcranial magnetic stimulation with functional magnetic resonance imaging capability: the UBC experience.

Ge, Ruiyang; Dipinto, Adam A.; Barlow, Laura; MacMillan, Erin L.; MacKay, Alex L.; Alfonso, Marianela de la Caridad Rodríguez; Vila‐Rodriguez, Fidel

doi:10.1016/j.brs.2017.01.520

Cited by 2 publications

(1 citation statement)

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“…This proof-of-concept phantom study demonstrated how concurrent TMS-fMRI procedures were implemented at the Neuroimaging facility of the University of British Columbia, for the purpose of using concurrent TMS-fMRI to better understand and treat TRD. Specifically, the use of an MRI-compatible TMS apparatus, a high-current filter box and physical separation of the TMS stimulator from the TMS coil helped reduce any potential static or dynamic artefacts that could have risen from the combination of these two neuroimaging tools (Ge et al, 2017). Given that the MRI scanner relies on a stable, constant, magnetic field, while the TMS apparatus relies on unstable magnetic field, we investigated where in the installation of the concurrent TMS-fMRI setup could potential artefacts arise from.…”

Section: Discussionmentioning

confidence: 99%

Implementation of a TMS-fMRI system: A primer

Alamian

et al. 2021

Preprint

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Transcranial magnetic stimulation (TMS) is a non-invasive and non-pharmacological intervention, approved for the treatment of individuals diagnosed with treatment-resistant depression. This well-tolerated approach uses magnetic pulses to stimulate specific brain regions and induce changes in brain networks at multiple levels of human functioning. Combining TMS with other neuroimaging techniques, such as functional magnetic resonance imaging (fMRI), offers new insights into brain functioning, and allows to map out the causal alterations brought on by TMS interventions on neural network connectivity and behaviour. However, the implemention of concurrent TMS-fMRI brings on a number of technical challenges that must be overcome to ensure good quality of functional images. The goal of this study was thus to investigate the impact of TMS pulses in an MR-environment on the quality of BRAINO phantom images, in terms of the signal of the images, the temporal fluctuation noise, the spatial noise and the signal to fluctuation noise ratio, at the University of British Columbia (UBC) Neuroimaging facility. The results of our analyses replicated those of previous sites, and showed that the present set-up for concurrent TMS-fMRI ensures minimal noise artefact on functional images obtained through this multimodal approach. This step was a key stepping stone for future clinical trials at UBC.

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Section: Discussionmentioning

confidence: 99%