A prior administration of heavy metals reduces thymus lymphocyte DNA lesions and lipid peroxidation in gamma-irradiated mice

Осипов, А. Н.; Ryabchenko, N.I.; Ivannik, B.P.; Dzikovskaya, L.A.; Ryabchenko, V.I.; Kolomijtseva, G. Ya.

doi:10.1051/jp4:20030464

Cited by 4 publications

(1 citation statement)

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“…ROS could also induce multiple localized lesions consisting in base damage, single-and double-strand breaks (SSBs and DSBs), DNA-DNA cross-links and DNA-protein crosslinks (Goldberg and Lehnert, 2002;Marnett et al, 2003;Asad et al, 2004). For example, it has been found that administration of heavy metals could reduce subsequent thymus lymphocyte DNA lesions and lipid peroxidation in gamma irradiated mice (Osipov et al, 2003) and many bacteria species have adaptive responses which protect them against the toxicity and mutagenicity of DNA alkylating agents (Sedgwick and Lindahl, 2002).…”

Section: The Adaptive Responsementioning

confidence: 99%

Adaptive response: some underlying mechanisms and open questions

2008

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Organisms are affected by different DNA damaging agents naturally present in the environment or released as a result of human activity. Many defense mechanisms have evolved in organisms to minimize genotoxic damage. One of them is induced radioresistance or adaptive response. The adaptive response could be considered as a nonspecific phenomenon in which exposure to minimal stress could result in increased resistance to higher levels of the same or to other types of stress some hours later. A better understanding of the molecular mechanism underlying the adaptive response may lead to an improvement of cancer treatment, risk assessment and risk management strategies, radiation protection, e.g. of astronauts during long-term space flights. In this mini-review we discuss some open questions and the probable underlying mechanisms involved in adaptive response: the transcription of many genes and the activation of numerous signaling pathways that trigger cell defenses -DNA repair systems, induction of proteins synthesis, enhanced detoxification of free radicals and antioxidant production.

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Section: The Adaptive Responsementioning

confidence: 99%

Adaptive response: some underlying mechanisms and open questions

2008

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Effects of Exposure of Animals to Oxygen Atmosphere at Low Pressure on Lipid Peroxidation and Antioxidant Defense

et al. 2018

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Relatively short-term (2.5 or 5 h) exposure of Wistar rats to oxygen atmosphere at moderate pressure (1.10-1.15 atm) resulted in an increase in LPO level and reduction of antioxidant activity in the blood serum. An increase in malondialdehyde concentration 1 day after termination of the exposure was followed by a decrease in the inhibiting activity of free radical oxidation of liposomal phospholipids induced by Fe(II) ions (100 μm). Malondialdehyde concentration increased by 1.29 times already after 2.5-h exposure and did not changed when the duration of the exposure to oxygen atmosphere was prolonged to 5 h. These data confirm the necessity of using substances potentiating antioxidant defense of the body during exposure to normobaric oxygenation.

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