A priority paper for the societal and ethical aspects of synthetic biology

Schmidt, Markus; Ganguli‐Mitra, Agomoni; Torgersen, Helge; Kelle, Alexander; Deplazes, Anna; Biller‐Andorno, Nikola

doi:10.1007/s11693-009-9034-7

Cited by 72 publications

(88 citation statements)

References 19 publications

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“…The pertinence of the stories not directly mentioning SB was assessed using a variety of authoritative descriptions of what SB involves (Benner and Sismour, 2005; IAP Global Network of Science Academies, 2014; Schmidt et al, 2009). …”

Section: Methodsmentioning

confidence: 99%

Uncritical and unbalanced coverage of synthetic biology in the Nordic press

et al. 2016

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Synthetic biology will probably have a high impact on a variety of fields, such as healthcare, environment, biofuels, agriculture, and so on. A driving theme in European research policy is the importance of maintaining public legitimacy and support. Media can influence public attitudes and are therefore an important object of study. Through qualitative content analysis, this study investigates the press coverage of synthetic biology in the major Nordic countries between 2009 and 2014. The press coverage was found to be event-driven and there were striking similarities between countries when it comes to framing, language use, and treated themes. Reporters showed a marked dependence on their sources, mainly scientists and stakeholders, who thus drives the media agenda. The media portrayal was very positive, with an optimistic look at future benefits and very little discussion of possible risks.

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Section: Methodsmentioning

confidence: 99%

Uncritical and unbalanced coverage of synthetic biology in the Nordic press

et al. 2016

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“…However, at the same 20 time there are also concerns and fears that this technology drifts too far away from nature. The academic literature has discussed different issues and concerns within the current debate [6,7,8,9,10,11]. Many concerns are known from the debate over "Genetically Modified…”

Section: Different Types Of Concerns On Societal and Ethical Implicatmentioning

confidence: 99%

Societal impact of synthetic biology: responsible research and innovation (RRI)

Gregorowius

Deplazes‐Zemp

2016

Essays in Biochemistry

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Synthetic biology is an emerging field at the interface between biology and engineering, which has generated many expectations for beneficial biomedical and biotechnological applications. At the same time, however, it has also raised concerns about risks or the aim of producing new forms of living organisms. Researchers from different disciplines as well as policymakers and the general public have expressed the need for a form of technology assessment that not only deals with technical aspects, but also includes societal and ethical issues. A recent and very influential model of technology assessment that tries to implement these aims is known as RRI (Responsible Research and Innovation). In this paper, we introduce this model and its historical precursor strategies. Based on the societal and ethical issues which are presented in the current literature, we discuss challenges and opportunities of applying the RRI model for the assessment of synthetic biology. AbstractSynthetic biology is an emerging field at the interface between biology and engineering, which has generated many expectations for beneficial biomedical and biotechnological applications. At the same time, however, it has also raised concerns about risks and benefits 5 or about the aim of producing new forms of living organisms. Researchers from different disciplines as well as policy makers and the general public have expressed the need for a form of technology assessment that does not only deal with technical aspects, but also includes societal and ethical issues. A recent and very influential model of technology assessment that tries to implement these aims is known as RRI ("Responsible Research and Innovation"). In 10 this paper we introduce this model and its historical precursor strategies. Based on the societal and ethical issues which are presented in the current literature, we discuss challenges and opportunities of applying the RRI model for the assessment of synthetic biology.

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“…This therapeutic approach has the advantage of keeping the genetic material of the treatment subject intact, thus reducing the severity of controversial ethical issues [174][175][176].…”

Section: Synthetic Gene Network For Drug Discovery (Figure 3)mentioning

confidence: 99%

Mammalian synthetic biology: emerging medical applications

Kis

Pereira

Homma

et al. 2015

J. R. Soc. Interface.

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In this review, we discuss new emerging medical applications of the rapidly evolving field of mammalian synthetic biology. We start with simple mammalian synthetic biological components and move towards more complex and therapy-oriented gene circuits. A comprehensive list of ON-OFF switches, categorized into transcriptional, post-transcriptional, translational and posttranslational, is presented in the first sections. Subsequently, Boolean logic gates, synthetic mammalian oscillators and toggle switches will be described. Several synthetic gene networks are further reviewed in the medical applications section, including cancer therapy gene circuits, immuno-regulatory networks, among others. The final sections focus on the applicability of synthetic gene networks to drug discovery, drug delivery, receptor-activating gene circuits and mammalian biomanufacturing processes.

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A priority paper for the societal and ethical aspects of synthetic biology

Cited by 72 publications

References 19 publications

Uncritical and unbalanced coverage of synthetic biology in the Nordic press

Uncritical and unbalanced coverage of synthetic biology in the Nordic press

Societal impact of synthetic biology: responsible research and innovation (RRI)

Mammalian synthetic biology: emerging medical applications

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