A PRISMA-compliant meta-analysis of MDM4 genetic variants and cancer susceptibility

Zhai, Yajing; Dai, Zhijun; He, Hairong; Gao, Fan; Yang, Lihong; Dong, Yalin; Lu, Jun

doi:10.18632/oncotarget.12558

Cited by 8 publications

(10 citation statements)

References 36 publications

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“…MDM4 rs4245739 was intensively studied in different types of cancer [ 18 , 22 , 35 , 36 , 43 , 44 , 45 ]. Part of them [ 35 , 36 ] found no association of this variant with cancer susceptibility, while others [ 22 , 43 , 44 , 45 ] found an association with reduced risk of cancer, mainly of breast cancer but not only. The published results are contradictory, depending on the cancer type.…”

Section: Discussionmentioning

confidence: 99%

Association Analysis of TP53 rs1042522, MDM2 rs2279744, rs3730485, MDM4 rs4245739 Variants and Acute Myeloid Leukemia Susceptibility, Risk Stratification Scores, and Clinical Features: An Exploratory Study

Tripon

Iancu

Crauciuc

et al. 2020

JCM

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This study aimed to explore the associations between the TP53 rs1042522 (TP53 Arg72Pro), MDM2 rs2279744 (MDM2 309T>G), rs3730485 (MDM2 del1518), MDM4 rs4245739 (MDM4 34091 C>A) variants and odds of developing acute myeloid leukemia (AML) in a cohort of 809 adult subjects, consisting of 406 healthy controls and 403 AML patients. Model-based multifactor dimensionality reduction (MB-MDR) framework was used to identify the interactions of the mentioned variants and their association with AML risk. Associations of the mentioned variants with clinical features of AML, somatic mutations, and response to treatment were also evaluated. Significant associations between TP53 rs1042522 and MDM4 rs4245739 variants and AML susceptibility were noticed. MB-MDR and logistic regression analysis revealed an interaction between MDM2 rs2279744 and TP53 rs1042522, between MDM4 rs4245739 and MDM2 rs3730485, as well as significant associations with AML susceptibility. Several associations between the mentioned variants and clinical features of AML and somatic mutations were also noticed. Individually, the variant genotypes of TP53 rs1042522 and MDM4 rs4245739 were associated with AML susceptibility, but their interaction with MDM2 rs2279744 and rs3730485 modulated the risk for AML. The variant genotypes of TP53 rs1042522 were associated with adverse molecular and cytogenetic risk and also with NPM1 mutations.

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Section: Discussionmentioning

confidence: 99%

Association Analysis of TP53 rs1042522, MDM2 rs2279744, rs3730485, MDM4 rs4245739 Variants and Acute Myeloid Leukemia Susceptibility, Risk Stratification Scores, and Clinical Features: An Exploratory Study

Tripon

Iancu

Crauciuc

et al. 2020

JCM

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“…Because of the limited numbers of included studies, we only assessed the publication bias of those investigating the IL-8 rs4073 polymorphism. Secondly, systematic review and meta-analysis is an observational study which was restricted by the quality of primary studies [ 6 , 16 , 33 – 35 ]. Although we had conducted a more comprehensive search, our study could not escape from this limitation.…”

Section: Discussionmentioning

confidence: 99%

“…Obviously, many other polymorphisms of IL-8 gene has not been explored, so we performed this analysis for further assessing the relationship between all IL-8 gene polymorphisms and periodontitis; additionally, we also reviewed which polymorphisms have been investigated. The present study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement [ 15 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of interleukin-8 gene polymorphisms and periodontitis susceptibility

Cheng

et al. 2017

Oncotarget

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BackgroundAssociations between interleukin-8 (IL-8) gene polymorphisms and periodontitis susceptibility have been investigated in many published studies, but the conclusions are still inconsistent. Therefore, we performed this systematic review and meta-analysis to review which polymorphisms have been researched and to obtain a precise result of the same polymorphism from different studies.ResultsFinally 10 publications involving 1938 patients and 1569 controls were yielded, including 12 polymorphisms. Six studies investigated rs4073 polymorphism; two focused on rs2227306 and rs2227307; two referred to rs2227532 and T-738A; one detected rs2230054, rs1126579 and rs1126580; one inspected A2767T, T11722T2 and C1633T, and one for rs2234671 polymorphism. Of them, IL-8 C1633T and rs1126580 polymorphisms showed positive association while the other ten polymorphisms revealed negative results.Materials and methodsA comprehensive literature search from PubMed, Web of Science, and Chinese National Knowledge Infrastructure was conducted for all potentially relevant studies published before January 2, 2017. Two authors selected the studies and extracted data. The pooled analysis was conducted using the RevMan 5.1 software if a polymorphism was reported by two or more studies.ConclusionsBased on current evidence, the IL-8 rs4073, A2767T, T11722T2, rs2234671, rs2230054, rs1126579, rs2227306, rs2227307, rs2227532, and T-738A polymorphisms were not associated with periodontitis susceptibility; the IL-8 C1633T and rs1126580 polymorphisms were associated with increased risk of periodontitis.

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“…We identified potential records from six databases (PubMed, WOS, EMBASE, CNKI, WANFANG, and Scopus). We performed a PRISMA (preferred reporting items for systematic reviews and meta-analyses [ 61 ])-compliant database search and study selection, and the relevant meta-analysis papers were referred [ 62 - 64 ]. Two authors (Yixin Zhang, Xiaoteng Cui) independently removed duplicate studies and assessed record eligibilities according to our exclusion/inclusion criteria.…”

Section: Methodsmentioning

confidence: 99%

The effects of tumor necrosis factor-α (TNF-α) rs1800629 and rs361525 polymorphisms on sepsis risk

Zhang

Cui

et al. 2017

Oncotarget

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This meta-analysis of 23 eligible articles comprehensively and quantitatively evaluated the effects of tumor necrosis factor-α (TNF-α) rs1800629 and rs361525 polymorphisms on sepsis risk. We found that TNF-α rs1800629 was associated with increased sepsis risk in the overall population in four genetic models, including A vs. G (P<0.001, odds ratio (OR)=1.32), GA vs. GG (P<0.001, OR=1.46), GA+AA vs. GG (P<0.001, OR=1.46), and carrier A vs. carrier G (P<0.001, OR=1.32). Subgroup analyses showed a similar result for Asian patients (all P<0.05, OR>1). TNF-α rs361525 was also associated with increased sepsis risk in Asian patients in the four genetic models (all P<0.05, OR>1). Begg’s and Egger’s tests excluded large publication bias, and sensitivity analysis indicated stable results. Our results suggest that the G/A genotype of TNF-α rs1800629 and rs361525 increases sepsis risk in an Asian population.

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A PRISMA-compliant meta-analysis of MDM4 genetic variants and cancer susceptibility

Cited by 8 publications

References 36 publications

Association Analysis of TP53 rs1042522, MDM2 rs2279744, rs3730485, MDM4 rs4245739 Variants and Acute Myeloid Leukemia Susceptibility, Risk Stratification Scores, and Clinical Features: An Exploratory Study

Association Analysis of TP53 rs1042522, MDM2 rs2279744, rs3730485, MDM4 rs4245739 Variants and Acute Myeloid Leukemia Susceptibility, Risk Stratification Scores, and Clinical Features: An Exploratory Study

Comprehensive analysis of interleukin-8 gene polymorphisms and periodontitis susceptibility

The effects of tumor necrosis factor-α (TNF-α) rs1800629 and rs361525 polymorphisms on sepsis risk

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