A Proactive Intervention Study in Metabolic Syndrome High-Risk Populations Using Phenome-Based Actionable P4 Medicine Strategy

Huang, Qiongrong; Hu, Zhiyuan; Zheng, Qiwen; Mao, Xuemei; Lv, Wenxi; Wu, Fei; Fu, Dapeng; Lu, Cuihong; Zeng, Changqing; Wang, Fei; Zeng, Qiang; Fang, Qiaojun; Hood, Leroy

doi:10.1007/s43657-023-00115-z

Phenomics

2024

DOI: 10.1007/s43657-023-00115-z

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A Proactive Intervention Study in Metabolic Syndrome High-Risk Populations Using Phenome-Based Actionable P4 Medicine Strategy

Qiongrong Huang,

Zhiyuan Hu,

Qiwen Zheng

et al.

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Cited by 3 publications

References 71 publications

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Metals and polycyclic aromatic hydrocarbons co-exposure: amino acid omics insights on blood glucose homeostasis

Zhao,

Yang,

Xing

et al. 2024

Journal of Environmental Sciences

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Metals and polycyclic aromatic hydrocarbons co-exposure: amino acid omics insights on blood glucose homeostasis

Zhao,

Yang,

Xing

et al. 2024

Journal of Environmental Sciences

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Effect of PFAS serum exposure pattern on the lipid metabolism: Time to step-forward in causal inference in epidemiology

Yang,

Li,

Mei

et al. 2024

Journal of Environmental Sciences

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Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis

Wan,

Wu,

Zhang

et al. 2024

Nutrients

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The efficacy of functional lipids with antioxidant properties in reducing cardiovascular risk has not been consistent. Randomized controlled trials (RCTs) reporting estimates for the effects of antioxidant functional lipid supplementations on cardiometabolic risk factors were searched up to 1 May 2024. Overall, antioxidant lipid supplementations, compared with placebo, had favorable effects on systolic blood pressure (lycopene: −1.95 [−3.54, −0.36] mmHg), low-density lipoprotein cholesterol (n6 fatty acid: −0.39 [−0.71, −0.06] mmol/L; astaxanthin: −0.11 [−0.21, −0.01] mmol/L), high-density lipoprotein cholesterol (n3 fatty acid: 0.20 [0.13, 0.27] mmol/L; n6 fatty acid: 0.08 [0.01, 0.14] mmol/L; astaxanthin: 0.13 [0.05, 0.21] mmol/L), total cholesterol (n6 fatty acid: −0.24 [−0.37, −0.11] mmol/L; astaxanthin: −0.22 [−0.32, −0.12] mmol/L; beta-carotene: −0.13 [−0.23, −0.04] mmol/L), triglyceride (n3 fatty acid: −0.37 [−0.47, −0.28] mmol/L; astaxanthin: −0.46 [−0.83, −0.10] mmol/L), and fasting blood insulin (astaxanthin: −2.66 [−3.98, −1.34] pmol/L). The benefits of antioxidant lipid supplementations appeared to be most evident in blood pressure and blood lipids in participants with different cardiometabolic health statuses. Notably, n9 fatty acid increased triglyceride and hemoglobin A1C in the total population, which increases CVD risk. Antioxidant lipid supplementations ameliorate cardiometabolic risk factors, while their effect may depend on type and cardiometabolic health status. Long-term RCTs are needed to corroborate risk–benefit ratios across different antioxidant functional lipid supplementation settings.

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A Proactive Intervention Study in Metabolic Syndrome High-Risk Populations Using Phenome-Based Actionable P4 Medicine Strategy

Cited by 3 publications

References 71 publications

Metals and polycyclic aromatic hydrocarbons co-exposure: amino acid omics insights on blood glucose homeostasis

Metals and polycyclic aromatic hydrocarbons co-exposure: amino acid omics insights on blood glucose homeostasis

Effect of PFAS serum exposure pattern on the lipid metabolism: Time to step-forward in causal inference in epidemiology

Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis

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