The turbine disc plays a crucial role in aerospace engine, significantly influencing both their fatigue life and overall reliability. Due to the substantial uncertainties present, devising a method for the probabilistic analysis of turbine disc fatigue life becomes crucial. This paper introduces a novel framework that combines adaptive Kriging Monte Carlo simulation (AK‐MCS) with a mean stress correction model to evaluate fatigue life distribution effectively. AK‐MCS, stands out as an algorithm that constructs a Kriging model, effectively reducing the need for an extensive finite element analysis. Furthermore, a mean stress correction model is proposed for the Masson‐Coffin equation tailored for fatigue life prediction of GH4133 disc material. This model has been empirically validated to be effective. The presented framework for probabilistic fatigue life analysis not only holds considerable engineering value but also offers innovative approaches for tackling analogous challenges in the field.