A Probe Based on a Soft Salt Complex for Ratiometric and Lifetime Imaging of Variations in Intracellular Oxygen Content

Ma, Yun; Dong, Yafang; Zou, Liang; Shen, Liang; Liu, Suyi; Liu, Shujuan; Huang, Wei; Zhao, Qiang; Wong, Wai Yeung

doi:10.1002/ejic.201800250

Cited by 11 publications

(2 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Zhao and co-workers have developed three anionic iridium(III) complexes ( 632 ) (Chart ) for monitoring intracellular O 2 levels . The red luminescent complex 632c has been paired with a cationic, blue fluorescent, and O 2 -insensitive polyfluorene-based CPE ( 633 ) or zinc(II) complex ( 634 ) to give water-soluble dual-emissive soft salts for ratiometric and lifetime imaging of O 2 in live cells. Iridium(III) and platinum(II) complexes have also been covalently conjugated with polyfluorene to develop dual-emissive CPEs ( 635 and 636 ). , These amphiphilic polymers self-assemble into ultrasmall Pdots with a particle size down to 10 nm in aqueous solution.…”

Section: Luminescent Transition Metal Complexes As Probes For Microen...mentioning

confidence: 99%

Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

Lee,

2024

Chem. Rev.

View full text Add to dashboard Cite

Luminescence imaging is a powerful and versatile technique for investigating cell physiology and pathology in living systems, making significant contributions to life science research and clinical diagnosis. In recent years, luminescent transition metal complexes have gained significant attention for diagnostic and therapeutic applications due to their unique photophysical and photochemical properties. In this Review, we provide a comprehensive overview of the recent development of luminescent transition metal complexes for bioimaging and biosensing applications, with a focus on transition metal centers with a d 6 , d 8 , and d 10 electronic configuration. We elucidate the structure−property relationships of luminescent transition metal complexes, exploring how their structural characteristics can be manipulated to control their biological behavior such as cellular uptake, localization, biocompatibility, pharmacokinetics, and biodistribution. Furthermore, we introduce the various design strategies that leverage the interesting photophysical properties of luminescent transition metal complexes for a wide variety of biological applications, including autofluorescence-free imaging, multimodal imaging, organelle imaging, biological sensing, microenvironment monitoring, bioorthogonal labeling, bacterial imaging, and cell viability assessment. Finally, we provide insights into the challenges and perspectives of luminescent transition metal complexes for bioimaging and biosensing applications, as well as their use in disease diagnosis and treatment evaluation.

show abstract

Section: Luminescent Transition Metal Complexes As Probes For Microen...mentioning

confidence: 99%

Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

Lee,

2024

Chem. Rev.

View full text Add to dashboard Cite

show abstract

“…Poor cellular uptake indicates a low cytotoxic effect on cells and tissues, making anionic Ir(III) complexes excellent candidates for cell-based disease diagnosis. Strategies for improving their cellular uptake such as incorporation with a bulky cage, 17,18 construction of cation-anion Ir(III) complex soft salts, [19][20][21][22] or embedding in cationic polymers 23 have successfully realized their use in imaging hypoxia in living cells. Innovative triggers are in urgent need to broaden the applications of anionic Ir(III) complexes in biosensing and bioimaging.…”

Section: Introductionmentioning

confidence: 99%

An ALP-responsive, anionic iridium complex for specific recognition of osteosarcoma cells

Shen,

Nong,

Zhang

et al. 2024

Dalton Trans.

View full text Add to dashboard Cite

show abstract

Constructing Multi‐Stimuli‐Responsive Luminescent Materials through Outer Sphere Electron Transfer in Ion Pairs

Shen

She

et al. 2019

Advanced Optical Materials

Self Cite

View full text Add to dashboard Cite

materials, which can be broadly applied as bioprobes, [2] environmental monitors, [3] optical data storage medium, [4] etc. Generally, the stimuli-responsive luminescent materials are designed based on an inner sphere mechanism for electron transfer, and there are very few examples of such materials based on the outer sphere electron transfer mechanism. In fact, the design and preparation of stimuli-responsive materials based on inner sphere electron transfer mechanism is more difficult because tedious synthetic procedures or complex covalent modifications are often involved (Figure 1a). Supramolecular interactions constructed materials can be considered as ideal candidates to overcome this limit. Ion pairs, particularly those in which one or both of the components are transition metal complexes, have attracted increasing attention recently. [5] The ion-paired materials are of practical importance in the development of organic light-emitting diode, [6] dye-sensitized solar cells, [7] catalysts, [8] chemical sensors, [9] as well as smart electronic devices. [10] Importantly, ionic donor− acceptor interactions may provide an outer sphere mechanism for electron transfer that would enable the construction of stimuli-responsive materials.Ionic phosphorescent iridium(III) complexes have received significant attention due to their appealing photophysical properties, such as high photoluminescence (PL) quantum yields, excellent photostability, significant Stokes shifts, and high sensitivity toward surrounding environments. [11] Among the various ionic iridium(III) complexes, bis-terpyridine iridium(III) complexes are one of the most attractive candidates for the formation of stimuli-responsive ion pairs due to the following features: i) rich photochemistry, complicated excited states, and remarkable photophysical properties are ideal for stimuli-responsive character, [12] ii) high cationic character (charge +3) enables strong electrostatic interactions between donor and acceptor, and iii) very high energy content in the excited states makes them powerful photo-oxidants, [13] ensuring efficient PET processes. Based on these facts, it was hypothesized that the emission intensity of a bis-terpyridine iridium(III) complex would be quenched by the addition of a strong electron donor via a PET process. Subsequently, the consumption Stimuli-responsive luminescent materials are of scientific and technological interest due to their wide range of optoelectronic applications. The utilization of photoinduced electron transfer (PET) reactions is an effective strategy to design various stimuli-responsive luminescent materials. To date, most of these materials are based on the inner sphere electron transfer mechanism, which refers to a redox chemical reaction that proceeds via a covalent bridge. In contrast, the method of using outer sphere electron transfer mechanism is superior to the covalent approach as it does not require tedious synthesis. Ion pairs, which are composed of two oppositely charged components, are ideal for t...

show abstract

A Probe Based on a Soft Salt Complex for Ratiometric and Lifetime Imaging of Variations in Intracellular Oxygen Content

Cited by 11 publications

References 45 publications

Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

An ALP-responsive, anionic iridium complex for specific recognition of osteosarcoma cells

Constructing Multi‐Stimuli‐Responsive Luminescent Materials through Outer Sphere Electron Transfer in Ion Pairs

Contact Info

Product

Resources

About