A probiotic has differential effects on allergic airway inflammation in A/J and C57BL/6 mice and is correlated with the gut microbiome

Abstract

The phenotypes of allergic airway diseases are influenced by the interplay between host genetics and the gut microbiota, which may be modulated by probiotics. We investigated the probiotic effects on allergic inflammation in A/J and C57BL/6 mice. C57BL/6 mice had increased gut microbiota diversity compared to A/J mice at baseline. Acetate producer probiotics differentially modulated and altered the genus abundance of specific bacteria, such as Akkermansia and Allistipes, in mouse strains. We induced airway inflammation followed by probiotic treatment and found that only A/J mice exhibited decreased inflammation, and the beneficial effects of probiotics in A/J mice were partially due to acetate production. To understand the relevance of microbial composition colonization in the development of allergic diseases, we implanted female C57BL/6 mice with A/J embryos to naturally modulate the microbial composition of A/J mice, which increased gut microbiota diversity and reduced eosinophilic inflammation in A/J. These data demonstrate the central importance of microbiota to allergic phenotype severity.

The Efficacy of Fecal Microbiota Transplantation in Experimental Autoimmune Encephalomyelitis: Transcriptome and Gut Microbiota Profiling

“…V-Lep ob /J, and NOD) is similar to each other on the bacterial relative distribution on higher taxonomic levels [ 66 ], while another study indicated mouse strain had remarkable effect on the abundance of Akkermansia and Lactobacillus [ 65 ]. Also, a recent study has shown that a probiotic played differential roles on allergic airway inflammation in A/J and C57BL/6 mice and was associated with gut microbiome [ 67 ]. Although gut microbiota is stable, it varies both in time and in different strains.…”

Association of Gut Microbiota With Intestinal Ischemia/Reperfusion Injury

“…It is reported that 95% of diseases are related to gut microbiota. In addition to gastrointestinal diseases, metabolic diseases, gut microbiota is also related to various system diseases, such as nervous system ( Vicentini et al., 2021 ; Saldana-Morales et al., 2021 ), respiratory system ( Zheng et al., 2020 ; Casaro et al., 2021 ), cardiovascular system ( Khan et al., 2021 ; Deng et al., 2022 ), tumor ( Yang et al., 2020 ; Chung et al., 2021 ; Murphy et al., 2021 ), etc. disease related.…”

Butyrate: Connecting the gut-lung axis to the management of pulmonary disorders

“…Asthma is an airway chronic inflammatory disorder characterized as a heterogeneous disease. In this review, we focused on the allergic asthma, which is the most common type of this disease ( 110 ). Allergic asthma is also associated with sensitization to aeroallergens such as air pollution, bacteria, pollen and virus.…”

“…It is well-established in the literature that perturbations in the gut microbiota are linked to allergic asthma ( 14 , 111 ). For instance, the use of antibiotics during pregnancy was found to be associated, in a dose-dependent way, with the severity of asthma in the offspring ( 108 ), and several studies have shown beneficial effects of soluble fiber intake and SCFA-producing probiotics for asthma inflammation throughout different stages of life ( 109 , 110 ). In this sense, SCFAs may influence the development of asthma via epigenetic regulation of distinct immune cell populations ( 19 ).…”