A Probiotic Mixture Induces Anxiolytic- and Antidepressive-Like Effects in Fischer and Maternally Deprived Long Evans Rats

Dauge, Valérie; Philippe, Catherine; Mariadassou, Mahendra; Rué, Olivier; Martin, Jean‐Charles; Rossignol, Marie; Dourmap, Nathalie; Svilar, Ljubica; Tourniaire, Franck; Monnoye, Magali; Jardet, Déborah; Bangratz, Marie; Holowacz, Sophie; Rabot, Sylvie; Naudon, Laurent

doi:10.3389/fnbeh.2020.581296

Cited by 9 publications

(3 citation statements)

References 64 publications

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“…In other studies, isolated cases of mild adverse events were reported. The first studies assessing the effect of probiotics on the alleviation of depression were presented in a mouse model [ 77 , 78 , 79 , 80 ] and a rat model [ 81 , 82 , 83 , 84 ], using one bacterial strain [ 79 , 81 ]. Animal model studies have produced promising results.…”

Section: Resultsmentioning

confidence: 99%

The Role of Psychobiotics in Supporting the Treatment of Disturbances in the Functioning of the Nervous System—A Systematic Review

Skowron

Budzyńska

Wiktorczyk-Kapischke

et al. 2022

IJMS

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Stress and anxiety are common phenomena that contribute to many nervous system dysfunctions. More and more research has been focusing on the importance of the gut–brain axis in the course and treatment of many diseases, including nervous system disorders. This review aims to present current knowledge on the influence of psychobiotics on the gut–brain axis based on selected diseases, i.e., Alzheimer’s disease, Parkinson’s disease, depression, and autism spectrum disorders. Analyses of the available research results have shown that selected probiotic bacteria affect the gut–brain axis in healthy people and people with selected diseases. Furthermore, supplementation with probiotic bacteria can decrease depressive symptoms. There is no doubt that proper supplementation improves the well-being of patients. Therefore, it can be concluded that the intestinal microbiota play a relevant role in disorders of the nervous system. The microbiota–gut–brain axis may represent a new target in the prevention and treatment of neuropsychiatric disorders. However, this topic needs more research. Such research could help find effective treatments via the modulation of the intestinal microbiome.

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Section: Resultsmentioning

confidence: 99%

The Role of Psychobiotics in Supporting the Treatment of Disturbances in the Functioning of the Nervous System—A Systematic Review

Skowron

Budzyńska

Wiktorczyk-Kapischke

et al. 2022

IJMS

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show abstract

“…F. prausnitzii was also reported to have anti-depressive and anxiolytic effects in chronic-stressed mice, and low populations of F. prausnitzii were found to be correlated with the disease severity of MDD and bipolar depression [ 130 ]. Chronic administration of a probiotic mixture of L. helveticus , B. longum , L. lactis , and S. thermophilus was found to affect anxiety- and depressive-like behaviors in rats, possibly due to changes in certain metabolites and brain monoamines [ 135 ].…”

Section: Role Of the Ngps In The Treatment And Control Of Human Diseasesmentioning

confidence: 99%

Next-Generation Probiotics as Novel Therapeutics for Improving Human Health: Current Trends and Future Perspectives

Abouelela,

Helmy

2024

Microorganisms

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Next-generation probiotics (NGPs) represent an innovative group of beneficial bacteria that are currently undergoing research and development. NGPs are designed not only for conventional use as foods or dietary supplements but are also tailored for pharmaceutical applications. Research indicates that NGPs show therapeutic promise in addressing various chronic ailments. Offering multiple advantages over conventional probiotics, NGPs present opportunities for personalized probiotic therapies, involvement in synthetic biology and gene editing, participation in combination therapies, targeted delivery methods, and application in therapeutic settings. Our review discusses the potential therapeutic effect of the NGPs, covering diverse research trajectories for NGPs, including their identification, characterization, and targeted delivery. Furthermore, this review elucidates the influence of NGPs on critical aspects of human health, specifically, gut health, immune function, and broader health outcomes. Mechanistic insights encompass the production of bioactive compounds, competitive interactions with pathogenic bacteria, the modulation of immune cell activity, and the reinforcement of the gut barrier. What is noteworthy is that the current review points out the prevalent NGP strains and their diverse sources, providing a highlight for the comprehensive framework for understanding their potential applications and their future benefits in the domain of advanced therapeutics.

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“…In another study, an administration of a probiotic formulation containing Lactobacillus plantarum , Lactobacillus rhamnosus , Bifidobacterium lactis , Bifidobacterium breve , and Pediococcus pentosaceus alleviated depressive-like behaviors in mice and decreased corticosterone level by restoring the gut microbiota composition ( Liu et al, 2020 ). In Fischer and Long Evans rats subjected to maternal deprivation, a probiotic mixture composed of Lactobacillus helveticus , Bifidobacterium longum , Lactococcus lactis , and Streptococcus thermophilus reduced anxiety- and depression-like behaviors accompanied by a change in the levels of certain metabolites ( Daugé et al, 2020 ).…”

Section: Probiotics As An Adjunctive Therapeutic Option For Depressionmentioning

confidence: 99%

A Reciprocal Link Between Gut Microbiota, Inflammation and Depression: A Place for Probiotics?

Eltokhi

Sommer

2022

Front. Neurosci.

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Depression is a severe mental disorder that places a significant economic burden on public health. The reciprocal link between the trillions of bacteria in the gut, the microbiota, and depression is a controversial topic in neuroscience research and has drawn the attention of public interest and press coverage in recent years. Mounting pieces of evidence shed light on the role of the gut microbiota in depression, which is suggested to involve immune, endocrine, and neural pathways that are the main components of the microbiota-gut-brain axis. The gut microbiota play major roles in brain development and physiology and ultimately behavior. The bidirectional communication between the gut microbiota and brain function has been extensively explored in animal models of depression and clinical research in humans. Certain gut microbiota strains have been associated with the pathophysiology of depression. Therefore, oral intake of probiotics, the beneficial living bacteria and yeast, may represent a therapeutic approach for depression treatment. In this review, we summarize the findings describing the possible links between the gut microbiota and depression, focusing mainly on the inflammatory markers and sex hormones. By discussing preclinical and clinical studies on probiotics as a supplementary therapy for depression, we suggest that probiotics may be beneficial in alleviating depressive symptoms, possibly through immune modulation. Still, further comprehensive studies are required to draw a more solid conclusion regarding the efficacy of probiotics and their mechanisms of action.

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A Probiotic Mixture Induces Anxiolytic- and Antidepressive-Like Effects in Fischer and Maternally Deprived Long Evans Rats

Cited by 9 publications

References 64 publications

The Role of Psychobiotics in Supporting the Treatment of Disturbances in the Functioning of the Nervous System—A Systematic Review

The Role of Psychobiotics in Supporting the Treatment of Disturbances in the Functioning of the Nervous System—A Systematic Review

Next-Generation Probiotics as Novel Therapeutics for Improving Human Health: Current Trends and Future Perspectives

A Reciprocal Link Between Gut Microbiota, Inflammation and Depression: A Place for Probiotics?

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