A procedure in mice to obtain intact pituitary-infundibulum-hypothalamus preparations: a method to evaluate the reconstruction of hypothalamohypophyseal system

Li, Kai; Zhang, Xiong; Zhou, Mingfeng; Ou, Yichao; Li, Weizhao; Wu, Guangsen; Che, Mengjie; Gong, Haihuan; Wang, Xingqin; Peng, Junjie; Zheng, Xiaoxuan; Li, Jiahui; Feng, Zhanpeng; Peng, Junxiang

doi:10.1007/s11102-023-01299-3

Pituitary

2023

DOI: 10.1007/s11102-023-01299-3

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A procedure in mice to obtain intact pituitary-infundibulum-hypothalamus preparations: a method to evaluate the reconstruction of hypothalamohypophyseal system

Kai Li

Xiong Zhang

Mingfeng Zhou

et al.

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Growth hormone promotes the reconstruction of injured axons in the hypothalamo-neurohypophyseal system

Li,

Feng,

Xiong

et al. 2023

Neural Regeneration Research

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Previous studies have shown that growth hormone can regulate hypothalamic energy metabolism, stress, and hormone release. Therefore, growth hormone has great potential for treating hypothalamic injury. In this study, we established a specific hypothalamic axon injury model by inducing hypothalamic pituitary stalk electric lesions in male mice. We then treated mice by intraperitoneal administration of growth hormone. Our results showed that growth hormone increased the expression of insulin-like growth factor 1 and its receptors, and promoted the survival of hypothalamic neurons, axonal regeneration, and vascular reconstruction from the median eminence through the posterior pituitary. Altogether, this alleviated hypothalamic injury-caused central diabetes insipidus and anxiety. These results suggest that growth hormone can promote axonal reconstruction after hypothalamic injury by regulating the growth hormone-insulin-like growth factor 1 axis.

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Growth hormone promotes the reconstruction of injured axons in the hypothalamo-neurohypophyseal system

Li,

Feng,

Xiong

et al. 2023

Neural Regeneration Research

View full text Add to dashboard Cite

show abstract

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A procedure in mice to obtain intact pituitary-infundibulum-hypothalamus preparations: a method to evaluate the reconstruction of hypothalamohypophyseal system

Cited by 1 publication

References 28 publications

Growth hormone promotes the reconstruction of injured axons in the hypothalamo-neurohypophyseal system

Growth hormone promotes the reconstruction of injured axons in the hypothalamo-neurohypophyseal system

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