A process analytical technology approach for the production of fixed-dose combination tablets of zidovudine and lamivudine using near infrared spectroscopy and chemical images

Grangeiro, Severino; França, Leandro de Moura; Pimentel, Maria Fernanda; Albuquerque, Manoel Bandeira de; Santana, Davi Pereira de; Santana, Aíla Karla Mota; Souza, Julia Aparecida Lourenço de; Simões, Simone da Silva

doi:10.1016/j.microc.2014.07.009

Cited by 8 publications

(3 citation statements)

References 30 publications

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“…Junior et al 9 used NIR and performed a comparison between two multivariate calibration techniques, PLSR and multiple linear regression (MLR) to monitor the quality control of tablets, and the PLSR model present better results than MLR. Raman spectral imaging technique was also used to predict active ingredient pharmaceutical concentration in microtablets 10 , in oral suspensions 11 , intravaginal rings 12 , and in quantitative assessment of pharmaceutical tablets 13 .…”

Section: Medical and Pharmaceutical Applicationsmentioning

confidence: 99%

Chemometrics in analytical chemistry – an overview of applications from 2014 to 2018

et al. 2019

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A compilation of papers published between 2014 and 2018 was evaluated. Many papers related to multivariate calibration and classification have been reported, as well as, design of experiments applications and artificial intelligence methods. Some applications were highlighted, as medical and pharmaceutical, food analysis, fuels, biological and forensic for the chemometric techniques on this review. Most studies are related to developing methods for practical solutions in industry or routine analysis. A promising scenario is shown considering the number of published papers: a total of 832 for this period using the keywords, multivariate classification, multivariate calibration, analysis, chemometrics, prediction, analytical chemistry, artificial neural networks (ANN), design of experiments (DoE) and factorial design. An useful overview for Analytical Chemistry researchers´ combined with Chemometrics is presented in this review.

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Section: Medical and Pharmaceutical Applicationsmentioning

confidence: 99%

Chemometrics in analytical chemistry – an overview of applications from 2014 to 2018

et al. 2019

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“…ZDV analysis by electrochemical [5][6][7], spectroscopic [8][9][10] and chromatographic [11][12][13] techniques has been reported (Table 1). The methodologies for the determination of ZDV in regard to sample handling, cost and sensitivity have been widely discussed.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of an Electrochemical Sensor Based on a Molecularly Imprinted Polymer for the Highly Sensitive and Selective Determination of the Antiretroviral Drug Zidovudine in Biological Samples

Karadurmus,

Ozkan

2023

Micromachines

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Molecularly Imprinted Polymers (MIP) have demonstrated considerable potential when combined with electrochemical sensors, exhibiting high sensitivity, selectivity and reproducibility levels. The aim of this work is to detect Zivudine (ZDV) in serum samples by means of an interface imprinting technique-based electrochemical sensor. Thus, ZDV was used as a template for the creation of an MIP-based electrochemical sensor, and differential pulse voltammetry (DPV) was used as the determination technique for the molecule. Electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) techniques were also used to characterize the electrochemical sensor capabilities, which showed a good linearity between 1.0 × 10−10 M and 1.0 × 10−9 M. ZDV was detected with a detection limit of 1.63 × 10−11 M, while the recovery analysis of spiked serum samples demonstrated that the sensor was highly selective.

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“…Although these drugs are generally present at rather low levels (from ng L −1 to μg L −1 ) in wastewater and surface waters [5][6][7], the continuous input can increase the concentrations bringing potential negative effects on the environment, e.g., antimicrobial resistance and toxicity to sensitive aquatic organisms. Their simultaneous determination in environmental samples, as well as in pharmaceutical dosage, biological fluids, animal tissue, synthetic mixtures, has been performed by near-infrared spectroscopy [8], high performance liquid chromatography with diode array detection (HPLC-DAD) [9], U-HPLC with tandem mass spectrometry detection (MS/MS) [10] and pH-gradient flow injection analysis (FIA) with DAD [11].…”

Section: Introductionmentioning

confidence: 99%

High-throughput chemometrically assisted flow-injection method for the simultaneous determination of multi-antiretrovirals in water

Fernández

Brasca

Alcaráz

et al. 2018

Microchemical Journal

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A process analytical technology approach for the production of fixed-dose combination tablets of zidovudine and lamivudine using near infrared spectroscopy and chemical images

Cited by 8 publications

References 30 publications

Chemometrics in analytical chemistry – an overview of applications from 2014 to 2018

Chemometrics in analytical chemistry – an overview of applications from 2014 to 2018

Fabrication of an Electrochemical Sensor Based on a Molecularly Imprinted Polymer for the Highly Sensitive and Selective Determination of the Antiretroviral Drug Zidovudine in Biological Samples

High-throughput chemometrically assisted flow-injection method for the simultaneous determination of multi-antiretrovirals in water

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