A process for prioritising systematic reviews in tinnitus

Sereda, Magdalena; McFerran, Don; Axon, Emma; Baguley, David; Hall, Deborah A.; Potgieter, Iskra; Cima, Rilana; Cox, Samantha; Hoare, Derek J.

doi:10.1080/14992027.2020.1733677

Cited by 10 publications

(8 citation statements)

References 39 publications

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“…Second, a lack of reviews of existing knowledge was indicated as an impediment to progress in tinnitus research. For example, a need for further Cochrane reviews for specific tinnitus interventions has recently been proposed (Sereda et al, 2020), since reviews for some commonly prescribed interventions are missing or are almost a decade old (Baldo et al, 2012). Additionally, systematic reviews would significantly contribute to selecting among the different available methods for assessing an individual with tinnitus and inform decisions for standardizing tinnitus assessment (Shabbir et al, 2021).…”

Section: Future Research Directionsmentioning

confidence: 99%

Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers

Simões

Daoud

Shabbir

et al. 2021

Front. Aging Neurosci.

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Tinnitus can be a burdensome condition on both individual and societal levels. Many aspects of this condition remain elusive, including its underlying mechanisms, ultimately hindering the development of a cure. Interdisciplinary approaches are required to overcome long-established research challenges. This review summarizes current knowledge in various tinnitus-relevant research fields including tinnitus generating mechanisms, heterogeneity, epidemiology, assessment, and treatment development, in an effort to highlight the main challenges and provide suggestions for future research to overcome them. Four common themes across different areas were identified as future research direction: (1) Further establishment of multicenter and multidisciplinary collaborations; (2) Systematic reviews and syntheses of existing knowledge; (3) Standardization of research methods including tinnitus assessment, data acquisition, and data analysis protocols; (4) The design of studies with large sample sizes and the creation of large tinnitus-specific databases that would allow in-depth exploration of tinnitus heterogeneity.

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Section: Future Research Directionsmentioning

confidence: 99%

Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers

Simões

Daoud

Shabbir

et al. 2021

Front. Aging Neurosci.

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“…The median (IQR) tinnitus duration was 5 (2-10) years. The median (range) THI at baseline was 44 (30-60), and the THI subscales, functional, emotional and catastrophic, were 16 (12-26), 16 (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26) and 12 (8)(9)(10)(11)(12)(13)(14), respectively. Baseline demographic characteristics and THI are listed in Table 1, The location of tinnitus (right, left or both ears), THI subscales, THI grade and the remaining baseline demographic characteristics are listed in eTable 2 in Supplement.…”

Section: Discussionmentioning

confidence: 99%

“…3 It is believed to improve cochlear blood flow 8 and neural function, 9 diminishing the effects of cochlear disfunction and central auditory hyperactivity. This is encouraged by promising scientific results (32.8% of clinical improvement vs. 17.0% untreated) 10,11 ; safety (similar to the placebo) 3 ; and accessibility even in emerging countries (e.g., 1 month of treatment cost about 5.0% of the Brazilian minimal wage). However, in a recent systematic review by Wegner et al, 3 only five clinical trials were selected, all of which were compromised by methodologic flaws.…”

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confidence: 99%

A triple blind, placebo controlled, randomised controlled trial of betahistine dihydrochloride in the treatment of primary tinnitus

Castilho

Dias

Martins

2022

Clinical Otolaryngology

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Objectives To evaluate the effectiveness of betahistine in the treatment of primary tinnitus. Design To evaluate the effectiveness of betahistine in the treatment of primary tinnitus. Setting Universidade estadual Paulista Julio de Mesquita Filho, Botucatu Medical School, São paulo, Brazil. Participants Adult patients with primary tinnitus who had not undergone treatment for tinnitus in the last 6 months were included. Patients with profound sensorineural deafness, hearing aid users and patients with metabolic, neurological, psychiatric or decompensated cardiovascular diseases were excluded. Study groups: in the betahistine group, patients received betahistine 24 mg every 12 h for 90 days; in the control group, patients received placebo tablets every 12 h for 90 days. Mean Outcome Measures Primary outcome measure: Tinnitus Handicap Inventory (THI). Secondary outcome measures: Clinical Global Impression Improvement (CGI‐I) and a question of ‘Yes’ or ‘No’ to participants about their perception of improvement in symptoms. Results Of 284 participants initially identified, 62 were randomised (betahistine group n = 31; control group n = 31). Median age (IQR) 54 (48–60) years, with a balanced number of men and women. There was no difference in THI outcome between the study groups (median difference, −2 points; 95% CI, −8 to 6 points); the THI after the intervention was a median (IQR) 4 (−4 to 14) lower points in the betahistine group, and a median (IQR) 2 (−6 to 10) in the control group. There was no statistical difference in secondary outcome measures. Adverse events were mild and there was no statistical difference between groups. Conclusions Betahistine dihydrochloride was ineffective in the treatment of primary tinnitus in adults.

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“…The hyperlipidemia of tinnitus patients should be treated, as these researchers noted. There is no gold standard in the treatment of tinnitus [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

The frequency of dyslipidemia in patients with idiopathic tinnitus

Erdoğdu¹

2021

North Clin Istanbul

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OBJECTIVE We aimed to investigate the presence of dyslipidemia in blood biochemistry of patients with idiopathic tinnitus and to point out that dyslipidemia poses a risk to coronary artery disease. METHODS Blood lipoprotein values and age and gender were compared between 158 patients with idiopathic tinnitus and 160 patients without tinnitus. Results were statistically evaluated. RESULTS In total, more than half of 318 patients had high blood cholesterol levels. In both groups, the cholesterol average was 215 mg/dl. Furthermore, low density lipoprotein (LDL) and high density lipoprotein (HDL) levels were higher than normal. However, no statistically significant difference was determined in the comparison of Cholesterol, HDL, and LDL levels in both groups (p<0.05). However, serum triglyceride levels of patients with tinnitus were when compared with the control group, a statistically significant difference was found (p=0.001); The numbers of men and women were approximately close to each other and the number of patients between the ages of 50 and 60 was higher. The average age is 53. As a result, the risk of life-threatening coronary heart disease increases, as the majority of patients with tinnitus are in the middle age group and have high lipoprotein values. CONCLUSION In patients presenting with the complaint of tinnitus, high serum lipoprotein values may not be directly related to tinnitus. However, it should be remembered that the presence of dyslipidemia may affect coronary vessels and lead to coronary artery diseases. However, a significant correlation was found between high serum triglyceride levels and tinnitus. In addition, if the patient has dyslipidemia, it will be healthy to treat dyslipidemia.

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A process for prioritising systematic reviews in tinnitus

Cited by 10 publications

References 39 publications

Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers

Multidisciplinary Tinnitus Research: Challenges and Future Directions From the Perspective of Early Stage Researchers

A triple blind, placebo controlled, randomised controlled trial of betahistine dihydrochloride in the treatment of primary tinnitus

The frequency of dyslipidemia in patients with idiopathic tinnitus

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