2022
DOI: 10.26434/chemrxiv-2022-t748w-v2
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A Prodrug Strategy for the In Vivo Imaging of Aldehyde Dehydrogenase Activity

Abstract: Therapy resistance is one of the biggest challenges facing clinical oncology. Despite a revolution in new anti-cancer drugs targeting multiple components of the tumour microenvironment, acquired or innate resistance frequently blunts the efficacy of these treatments. Non-invasive identification of drug-resistant tumours will enable modification of the patient treatment pathway through the selection of appropriate second-line treatments. Here, we have designed a pro-drug radiotracer for the non-invasive imaging… Show more

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