A Prognostic Model Based on TMB-Related Lncrnas Predicts Outcome of Liver Cancer Patients

Abstract

TMB-related lncrnas and their clinical significance in liver cancer have not been explored.Combining the expression levels of these lncrnas, somatic mutation files and clinical information in patients with liver cancer,we identified 514 lncrnas that are closely related to TMB.Based on these lncrnas, a TMB-derived lncRNA Signature (TMBLncSig) was established. TMBLncSig categorized the patients into high-risk group and low-risk group. There was a significant difference in the prognosis of the patients between the two groups, which was further verified in the independent test set.TMBLncSig is associated with TMB level in liver cancer patients and has the potential to be used as a TMB level measurement tool. In summary this st provide new thought for further study on the role of lncRNA in the difference of TMB level in liver cancer patients.