A Program for Treating Olanzapine-Related Weight Gain

Abstract

This study evaluated the effectiveness of a Weight Watchers program for patients with schizophrenia who had olanzapine-related weight gain and ascertained whether the severity of patients' psychiatric symptoms was correlated with the patients' success in losing weight. Seven men and four women who had been treated with olanzapine and who had gained at least 7 percent of their pretreatment body weight attended Weight Watchers meetings and were offered supervised exercise sessions. The patients' weight, body mass index, and psychiatric symptoms were assessed and were compared with those of a matched comparison group who did not attend the Weight Watchers program. Only the men experienced significant weight loss. No correlation was found between weight loss and exercise or change in psychiatric symptoms.

Lifestyle Interventions for Adults With Serious Mental Illness: A Systematic Literature Review

“…The rest of the studies specified medication inclusion criteria that were either restricted to monotherapy with one antipsychotic medication at the time of enrollment (26,27) or combination treatment of one antipsychotic with other psychotropics (16,20,21,24,25,31,32,36). Three studies restricted their intervention to patients taking olanzapine (17,19,22). Only one study was designed to test the weight loss effects of a lifestyle intervention among patients who switched from olanzapine to risperidone (19).…”

“…Intervention formats featured individual sessions (29) and group sessions (16,17,19,21,23,26–28,31–34,36,37), with some integrating both approaches (20,22,24,25,38). Interventions were delivered by a range of staff, including registered nurses, exercise physiologists, registered dieticians, trained fitness instructors, case managers, and master's- and doctoral-level health care practitioners.…”

Selection, Use and Psychometric Properties of Physical Activity Measures to Assess Individuals with Severe Mental Illness: A Narrative Synthesis

“…19 studies utilised SRQs Archie et al, 2007Arbour, Faulkner, & Cohn, 2010;Brown, Birtwistle, Roe, & Thompson, 1999, Brown, Goetz, Van Sciver, Sullivan, & Hamera, 2006Dubbert et al, 2006;Ellingrod et al, 2011;Elmslie, Mann, Silverstone, Williams, & Romans, 2001;Faulkner et al, 2006;Lassenigus, kerlind, Wiklund-Gustin, Arman, & Söderlund, 2013;Lindamer et al, 2008;McLeod, Jaques, & Deane, 2009;Osborn, Nazareth, & King, 2007;Ratliff et al, 2012;Ussher, 2003;Ussher, Doshi, Sampuran, & West, 2011;Van Citters et al, 2010;Vancampfort, Probst, Knapen, Carraro, & De Hert, 2012. Excluded studies (with reason) 55 did not use an outcome measure that provided an assessment of the three fundamental domains of physical activity Acil, Dogan, & Dogan, 2008;Adams, 1995;Aquila, 2000;Archie, Wilson, Osborne, Hobbs, & McNiven, 2003;Ball, Coons, & Buchanan, 2001;Barton, Griffin, & Pretty, 2012;Beebe et al, 2005;Bobes et al, 2010a,b, Bobes, Arango, Garcia-Garcia, & Rejas, 2010bBrill et al, 2007;Brunero & Lamont, 2010;Buhagiar, Parsonage, & Osborn, 2011;Centorrino et al, 2006;Charmove, 1986;Chuang, Mansell, & Pattern, 2008;Crone et al, 2004;Daumit et al, 2005;Davidson et al, 1999Davidson et al, , 2001…”

A dedicated nurse-led service for antipsychotic-induced weight gain

“…Pharmacological interventions are not recommended as suitable for the majority of patients (Werneke et al, 2002). A systematic search of Medline and PubMed revealed several instances of non-pharmacological management of antipsychoticinduced weight gain in people with severe mental illness (Ball et al 2001;Umbricht et al, 2001;Littrell et al, 2003). Littrell et al randomised 70 patients treated with olanzapine to receive either psychoeducation or no intervention.…”