A programmable, fast-fixing, osteo-regenerative, biomechanically robust bone screw

Zhang, Yuanchi; Hu, Jinlian; Xie, Ruiqi; Yang, Yaning; Cao, Jie; Tu, Yun-hu; Zhang, Yi; Qin, Tingwu; Zhao, Xin

doi:10.1016/j.actbio.2019.12.017

Cited by 33 publications

(25 citation statements)

References 57 publications

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“…After being recovered at 80 °C, the final height was L r . Then the shape fixity ratio (R f ) and shape recovery ratio (R r ) could be calculated according to the equations [ 8 ].

…”

Section: Methodsmentioning

confidence: 99%

“…FEA: FEA was used to further investigate the stress at the interface between the 3D printed scaffold and the bone tissues by the software Abaqus 6.14 (Dassault Systèmes, France). In this study, the scaffold and defective site in the cancellous bone were simplified to a cylinder and a cuboid, where the recovery process of scaffold in the defective bone would be simulated [ 8 ]. Materials used in the FEA model were set to be isotropic, homogeneous and linearly elastic.…”

Section: Methodsmentioning

confidence: 99%

“…Various kinds of synthetic biomaterials have been explored as bone grafts, e.g. metals, ceramics and hydrogels, however, they also encounter some drawbacks, including unsatisfied mechanical and bioactive performances [ [7] , [8] , [9] , [10] , [11] ]. What is more, it has been reported that poor integration between the grafts and bone tissues lead to increased loose risks and ineffective treatment [ [12] , [13] , [14] ].…”

Section: Introductionmentioning

confidence: 99%

“…Advances in SMPs hold considerable promises for patients with bone defects, that allow the implants to be pre-programmed to a smaller size and then recovered after being inserted so that the defective site could be well supported and fixed [ 36 ]. The shape recovery process could also strengthen the tightness of contact between the material and the surrounding tissue, improving osseointegration [ 8 ]. Also, a poly(ε-caprolactone)-based SMP scaffold with the self-fitting ability was developed for treating irregular bone defects [ 37 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

3D-printed NIR-responsive shape memory polyurethane/magnesium scaffolds with tight-contact for robust bone regeneration

Zhang

et al. 2022

Bioactive Materials

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“…After being recovered at 80 °C, the final height was L r . Then the shape fixity ratio (R f ) and shape recovery ratio (R r ) could be calculated according to the equations [ 8 ].

…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

3D-printed NIR-responsive shape memory polyurethane/magnesium scaffolds with tight-contact for robust bone regeneration

Zhang

et al. 2022

Bioactive Materials

Self Cite

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“…Moreover, a better fitting of the scaffold to the patients defect shape and size could be achieved with this approach. Different bioactive agents have been incorporated into SMPs, including hydroxyapatite [ [22] , [23] , [24] ], polydopamine [ 9 ], proteins [ 24 ] and chondrogenic molecules [ 14 ]. An additional advantage of SMPs is their easy processability, enhancing their possibility of applications.…”

Section: Introductionmentioning

confidence: 99%

Nanocomposite electrospun fibers of poly(ε-caprolactone)/bioactive glass with shape memory properties

Liverani

Liguori

Zezza

et al. 2022

Bioactive Materials

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Electrospun fibers of shape memory triethoxysilane-terminated poly(epsilon-caprolactone) (PCL-TES) loaded with bioactive glasses (BG) are here presented. Unloaded PCL-TES, as well as PCL/BG nanocomposite fibers, are also considered for comparison. It is proposed that hydrolysis and condensation reactions take place between triethoxysilane groups of the polymer and the silanol groups at the BG particle surface, thus generating additional crosslinking points with respect to those present in the PCL-TES system. The as-spun PCL-TES/BG fibers display excellent shape memory properties, in terms of shape fixity and shape recovery ratios, without the need of a thermal crosslinking treatment. BG particles confer in vitro bioactivity to PCL-based nanocomposite fibers and favor the precipitation of hydroxycarbonate apatite on the fiber surface. Preliminary cytocompatibility tests demonstrate that the addition of BG particles to PCL-based polymer does not inhibit ST-2 cell viability. This novel approach of using bioactive glasses not only for their biological properties, but also for the enhancement of shape memory properties of PCL-based polymers, widens the versatility and suitability of the obtained composite fibers for a huge portfolio of biomedical applications.

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Injectable, Self‐Contained, Subaqueously Cross‐Linking Laminous Adhesives for Biophysical‐Chemical Modulation of Osteochondral Microenvironment

Yang

Yeung

et al. 2023

Adv Funct Materials

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Current osteochondral (OC) defect repair approaches using premade scaffolds face clinical limitations due to invasiveness, weak integrity, and/or insufficient interfacial bonding. An injectable hydrophobic laminous adhesive is developed that rapidly photocross‐link subaqueously and forms robust bi‐layered structure that orchestrates biophysical‐chemical cues for stimulating OC repair. Liquid hydrophobic photo‐cross‐linkable poly (lactide‐co‐propylene glycol‐co‐lactide) dimethacrylates (PmLnDMA) are adopted as cartilage phase and PmLnDMA encapsulating methacrylated hydroxyapatite nanoparticles (PmLnDMA/MH) as the mineralized subchondral bone phase. Both phases exhibit strong interfacial bonding due to the presence of “CC”. Mechanotransduction and growth factor‐mediated signaling pathways are enchanced by matching the mechanical properties of two phases to native cartilage and bone via systematical modulation of the adhesives’ composition and encapsulated growth factors’ release profile. This enhances mesenchymal stem cells’ commitment to corresponding chondrocytes and osteoblasts to augment OC repair in vitro and in vivo, and ultimately benefits patients suffering from OC fracture, osteoarthritis, and osteoporosis.

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A programmable, fast-fixing, osteo-regenerative, biomechanically robust bone screw

Cited by 33 publications

References 57 publications

3D-printed NIR-responsive shape memory polyurethane/magnesium scaffolds with tight-contact for robust bone regeneration

3D-printed NIR-responsive shape memory polyurethane/magnesium scaffolds with tight-contact for robust bone regeneration

Nanocomposite electrospun fibers of poly(ε-caprolactone)/bioactive glass with shape memory properties

Injectable, Self‐Contained, Subaqueously Cross‐Linking Laminous Adhesives for Biophysical‐Chemical Modulation of Osteochondral Microenvironment

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