A programmable polymer library that enables the construction of stimuli-responsive nanocarriers containing logic gates

Zhang, Penghui; Gao, Di; An, Keli; Shen, Qi; Wang, Chen; Zhang, Yuchao; Pan, Xiaoshu; Chen, Xigao; Lyv, Yifan; Cui, Cheng; Liang, Tingxizi; Duan, Xili; Liu, Jie; Yang, Tie‐Lin; Hu, Xiaoxiao; Zhu, Jun‐Jie; Xu, Feng; Wang, Tan

doi:10.1038/s41557-020-0426-3

Cited by 143 publications

(100 citation statements)

References 57 publications

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“…Till now, the intelligent in vitro and cellular bio-applications of DNA computing were vividly demonstrated. Except that, logic-directed CRISPR gene editing circuits, stimuli-responsive nanocontainers programmed by logical polymer library and other works were also reported [120,121] These works integrated both logic's stringency and excellent biocompatibility of biomaterials, and will lay robust foundation for logic-guided other applications in the future.…”

Section: Wwwadvancedsciencecommentioning

confidence: 97%

Propelling DNA Computing with Materials’ Power: Recent Advancements in Innovative DNA Logic Computing Systems and Smart Bio‐Applications

Fan

Wang

et al. 2020

Advanced Science

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DNA computing is recognized as one of the most outstanding candidates of next-generation molecular computers that perform Boolean logic using DNAs as basic elements. Benefiting from DNAs' inherent merits of low-cost, easy-synthesis, excellent biocompatibility, and high programmability, DNA computing has evoked substantial interests and gained burgeoning advancements in recent decades, and also exhibited amazing magic in smart bio-applications. In this review, recent achievements of DNA logic computing systems using multifarious materials as building blocks are summarized. Initially, the operating principles and functions of different logic devices (common logic gates, advanced arithmetic and non-arithmetic logic devices, versatile logic library, etc.) are elaborated. Afterward, state-of-the-art DNA computing systems based on diverse "toolbox" materials, including typical functional DNA motifs (aptamer, metal-ion dependent DNAzyme, G-quadruplex, i-motif, triplex, etc.), DNA tool-enzymes, non-DNA biomaterials (natural enzyme, protein, antibody), nanomaterials (AuNPs, magnetic beads, graphene oxide, polydopamine nanoparticles, carbon nanotubes, DNA-templated nanoclusters, upconversion nanoparticles, quantum dots, etc.) or polymers, 2D/3D DNA nanostructures (circular/interlocked DNA, DNA tetrahedron/polyhedron, DNA origami, etc.) are reviewed. The smart bio-applications of DNA computing to the fields of intelligent analysis/diagnosis, cell imaging/therapy, amongst others, are further outlined. More importantly, current "Achilles' heels" and challenges are discussed, and future promising directions of this field are also recommended.

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Section: Wwwadvancedsciencecommentioning

confidence: 97%

Propelling DNA Computing with Materials’ Power: Recent Advancements in Innovative DNA Logic Computing Systems and Smart Bio‐Applications

Fan

Wang

et al. 2020

Advanced Science

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“…As each stimuli-responsive nanocarrier has different advantages and limitations (Table 2), with additional stimuli responsiveness, nanocarriers can be more attuned to the stimuli changes and exert therapeutic effects in a more precise fashion. Recently, a programmable polymer library for stimuli-responsive nanocarriers containing logic gates has also been developed to gather systemic information in order to achieve precision medicine [142,143]. Another example in the anticancer drug delivery system is the nanocarriers designed to respond to the tumor microenvironment which can switch its size and morphology in response to the acidic tumor microenvironment and near-infrared laser irradiation [144].…”

Section: Multimodal Nanocarriersmentioning

confidence: 99%

Section: Strategies To Enhance Drug Delivery Efficiencymentioning

confidence: 99%

Recent Advances in Nanocarrier-Assisted Therapeutics Delivery Systems

Kang

2020

Pharmaceutics

150

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Nanotechnologies have attracted increasing attention in their application in medicine, especially in the development of new drug delivery systems. With the help of nano-sized carriers, drugs can reach specific diseased areas, prolonging therapeutic efficacy while decreasing undesired side-effects. In addition, recent nanotechnological advances, such as surface stabilization and stimuli-responsive functionalization have also significantly improved the targeting capacity and therapeutic efficacy of the nanocarrier assisted drug delivery system. In this review, we evaluate recent advances in the development of different nanocarriers and their applications in therapeutics delivery.

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“…When talking about a therapeutic response in these studies, we refer to the ability of the logic system to respond to and treat disease conditions either in cells or in animals. For example, this could refer to a probe that knows to release doxorubicin (DOX) only in the presence of cancer cells, whereupon a decrease in cell viability is observed [27], or to a protein able to attach to cell membranes and detectably form pores under predetermined conditions [28]. Alternatively, it could refer to vehicles that are administered to living, tumor‐bearing mice and the specific conditions of the tumor environment release proapoptotic agents and the tumor notably shrinks with limited side‐effects [24].…”

Section: Choice Of Outputmentioning

confidence: 99%

Fluorescence for biological logic gates

Barnoy

Popovtzer

Fixler

2020

Journal of Biophotonics

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Biological logic gates are smart probes able to respond to biological conditions in behaviors similar to computer logic gates, and they pose a promising challenge for modern medicine. Researchers are creating many kinds of smart nanostructures that can respond to various biological parameters such as pH, ion presence, and enzyme activity. Each of these conditions alone might be interesting in a biological sense, but their interactions are what define specific disease conditions. Researchers over the past few decades have developed a plethora of stimuli‐responsive nanodevices, from activatable fluorescent probes to DNA origami nanomachines, many explicitly defining logic operations. Whereas many smart configurations have been explored, in this review we focus on logic operations actuated through fluorescent signals. We discuss the applicability of fluorescence as a means of logic gate implementation, and consider the use of both fluorescence intensity as well as fluorescence lifetime.

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A programmable polymer library that enables the construction of stimuli-responsive nanocarriers containing logic gates

Cited by 143 publications

References 57 publications

Propelling DNA Computing with Materials’ Power: Recent Advancements in Innovative DNA Logic Computing Systems and Smart Bio‐Applications

Propelling DNA Computing with Materials’ Power: Recent Advancements in Innovative DNA Logic Computing Systems and Smart Bio‐Applications

Recent Advances in Nanocarrier-Assisted Therapeutics Delivery Systems

Fluorescence for biological logic gates

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