A Prolyl Endopeptidase-Inhibiting Benzofuran Dimer from Polyozellus multiflex

Song, Kyung‐Sik; Raskin, Ilya

doi:10.1021/np010194b

Cited by 48 publications

(17 citation statements)

References 24 publications

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“…IC 50 values of compounds 1 and 2 were comparable to those of the reported strong natural inhibitors such as staurosporine [13], isotamarixen (IC 50 = 0.25 mM [14]), propeptin (IC 50 = 1.1 mM [15]), and kinapsin-24 (IC 50 = 1.14 mM [16]); thus, these compounds may have a potential use in the prevention and treatment of Alzheimer's disease in spite of their allergic effect [10].…”

supporting

confidence: 68%

Prolyl Endopeptidase Inhibitors from the Leaves ofGinkgo biloba

Lee

et al. 2004

Planta med

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Prolyl endopeptidase (PEP, EC 3.4.21.26) hydrolyzes proline-containing neuropeptides, such as vasopressin, substance P, and thyrotropin-releasing hormone (TRH), and is suggested to participate in learning and memory processes. Ginkgo biloba leaves, upon examination for anti-amnestic constituents as new types of PEP inhibitors, showed significant PEP inhibition. PEP activity-guided fractionation and column chromatography of the MeOH extracts of G. biloba leaves resulted in the isolation of 6-(8'Z-pentadecenyl)salicylic acid (1) and 6-(10'Z-heptadecenyl)salicylic acid (2). The kinetic study indicated that compounds 1 and 2 are non-competitive inhibitors of prolyl endopeptidase with Ki values of 0.87 and 0.80 microM, respectively.

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supporting

confidence: 68%

Prolyl Endopeptidase Inhibitors from the Leaves ofGinkgo biloba

Lee

et al. 2004

Planta med

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“…asc.wiley-vch.de tures are found in natural products, [19] in organic chiral electrodes [20] and in diphosphinel igands. [21] However, under the optimised indole-indole homocoupling conditions,t he reactionw as only applicable to the coupling of electronr ich 2-(4-methoxyphenyl)-substituted benzofuran and benzothiophene with low isolated yields ( Table 2, entries 10 and 11).…”

Section: Scopeoft He Reactionmentioning

confidence: 99%

Carbocatalysed Oxidative CC Homocouplings of Benzo‐Fused Heterocycles

et al. 2015

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Appropriate and fine-tuned treatments of amorphous carbon (AC) involving aqua regia or concentrated HNO 3 leadt oo xidised carbon materials (oAC) which are able to catalyse 2,2'-a nd 3,3'-homocouplings of various functionalised indoles with outstandinga ctivity.T his newly developed carbocatalysed C sp 2 À C sp 2 bondf ormation can be achieved under mild thermalc onditions.T he study on the scope of the reactionr evealed that the reaction can be extended to the homocoupling of other substrates of high synthetic interest such as 2-naphthol, 2-functionalised benzofurans and benzothiofurans. Thec haracterisation of oACw ith XPS together with ad hoc experiments aimeda tb locking the active site revealed that the presence and distribution of C=Of unctionalities is critical and correlates well with the catalytic activity.S uch experiments provide solid support for elucidationo ft he mechanism, suggesting aq uinone nature of the active C= Og roups,w hich are spontaneously regenerated by oxygen. This is confirmed by the fact that 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) is able to promote the coupling in as toichiometricf ashion.

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“…Another new benzofuran dimer, kynapcin-24 (83), was later isolated from P multiplex. It inhibited PEP with an IC 50 value of 1.14 µM [183]. Separation of a methanol extract of fruiting bodies of P multiplex collected in Korea afforded linoleic acid and oleic acid together with thelephoric acid [184].…”

Section: Polyozellus Multiplex (Underw) Murrillmentioning

confidence: 99%

“…Polyozellic acid (79) (antiangiogenesis [181], β-secretase (BACE1) inhibitory activities [175] and neuroprotective effects [175]), compound 80 (antiangiogenesis activity [181]). Kynapcin-13 (81) and -28 (82) (PEP inhibitory activity [182]), Kynapcin-24 (83) (PEP inhibitory activity [183]).…”

Section: Thelephora Ganbajun M Zangmentioning

confidence: 99%

Bioactive Phytochemical Constituents of Wild Edible Mushrooms from Southeast Asia

et al. 2020

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Mushrooms have a long history of uses for their medicinal and nutritional properties. They have been consumed by people for thousands of years. Edible mushrooms are collected in the wild or cultivated worldwide. Recently, mushroom extracts and their secondary metabolites have acquired considerable attention due to their biological effects, which include antioxidant, antimicrobial, anti-cancer, anti-inflammatory, anti-obesity, and immunomodulatory activities. Thus, in addition to phytochemists, nutritionists and consumers are now deeply interested in the phytochemical constituents of mushrooms, which provide beneficial effects to humans in terms of health promotion and reduction of disease-related risks. In recent years, scientific reports on the nutritional, phytochemical and pharmacological properties of mushroom have been overwhelming. However, the bioactive compounds and biological properties of wild edible mushrooms growing in Southeast Asian countries have been rarely described. In this review, the bioactive compounds isolated from 25 selected wild edible mushrooms growing in Southeast Asia have been reviewed, together with their biological activities. Phytoconstituents with antioxidant and antimicrobial activities have been highlighted. Several evidences indicate that mushrooms are good sources for natural antioxidants and antimicrobial agents

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A Prolyl Endopeptidase-Inhibiting Benzofuran Dimer from Polyozellus multiflex

Cited by 48 publications

References 24 publications

Prolyl Endopeptidase Inhibitors from the Leaves ofGinkgo biloba

Prolyl Endopeptidase Inhibitors from the Leaves ofGinkgo biloba

Carbocatalysed Oxidative CC Homocouplings of Benzo‐Fused Heterocycles

Bioactive Phytochemical Constituents of Wild Edible Mushrooms from Southeast Asia

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