A promising alternative anti-HBV agent: The targeted ribonuclease

Li, Yinghui; Zhao, Ya; Li, Jun; Huang, Yongye; Liu, Zhongxiang; Xue, Cong

doi:10.3892/ijmm_00000434

Cited by 7 publications

(3 citation statements)

References 34 publications

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“…Adamantane is a well-known building block that features highly ordered self-assembled structures based entirely on Van der Waals interactions. [13][14][15] This was shown to result in remarkable electronic properties of functionalized adamantane monolayers. [16][17][18] Moreover, the high symmetry and dynamic nature of functionalized adamantane analogues have been explored for use as functional elements of plastic crystals and molecular machines, such as supramolecular rotors, [19] however their utility in layered perovskites remains uncertain.…”

Section: Supramolecular Designmentioning

confidence: 99%

Supramolecular Engineering for Formamidinium‐Based Layered 2D Perovskite Solar Cells: Structural Complexity and Dynamics Revealed by Solid‐State NMR Spectroscopy

Milić

Kubicki

et al. 2019

Advanced Energy Materials

149

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represent a class of materials described by the general formula S 2 Y n−1 M n X 3n+1 , where S (typically C m H 2m+1 NH 3 + ) and Y (typically methylammonium (MA), formamidinium (FA), or their mixtures) are organic cations, M is a divalent metal cation (Pb 2+ , Sn 2+ ), and X is a halide ion (Br − , I − ). RPPs form layered structures of perovskite-like slabs separated by the organic ammonium cation spacers (S), where the value of n represents the number of layers of [MX 6 ] 4− octahedra in the stack (Figure 1a; n = 1-3). These structural features render the RPPs natural quantum wells where the number of layers in conjunction with the nature of the spacer group determines the optoelectronic properties. [1][2][3] While MA-based layered perovskite compositions have been extensively explored, [3,5,6] reports of FA-based layered perovskites remain scarce despite the better stability of the FA cation. [7][8][9] In addition, unlike their 3D analogues, layered 2D perovskites generally suffer from poor solarto-electric power conversion efficiencies, [1][2][3] particularly for the FA-based layered perovskites reported to date. Despite the ongoing effort, some of the best performing MA-based layered 2D perovskites have exceeded efficiencies of 12% with hotcasting techniques, [3] whereas the present FA-based analogues gave efficiencies around 1% for various compositions, reaching over 6% after extensive treatments. [7][8][9] This relatively poor performance of RPPs can be predominantly attributed to the inhibition of charge transport by the organic cations that act as insulating layers, since it is the inorganic domains that mainly contribute to the conductivity of the system. [1] Moreover, RPPs possess higher exciton binding energies, which result in decreased performance owing to inefficient exciton dissociation, and in turn to short-circuit photocurrent losses. [3,5] This has been counterbalanced by using additives, such as thiourea, [7][8][9] or employing hot-casting fabrication techniques, [1] with limited reproducibility as well as lack of operational stability reports.Here, we consider that these limitations on the performance of RPPs might be overcome by exploiting the potential tunability of the inherent structural properties through the design Perovskite solar cells are one of the most promising photovoltaic technologies, although their molecular level design and stability toward environmental factors remain a challenge. Layered 2D Ruddlesden-Popper perovskite phases feature an organic spacer bilayer that enhances their environmental stability. Here, the concept of supramolecular engineering of 2D perovskite materials is demonstrated in the case of formamidinium (FA) containing A 2 FA n−1 Pb n I 3n+1 formulations by employing (adamantan-1-yl)methanammonium (A) spacers exhibiting propensity for strong Van der Waals interactions complemented by structural adaptability. The molecular design translates into desirable structural features and phases with different compositions and dimensionalities, identified uniquely ...

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Section: Supramolecular Designmentioning

confidence: 99%

Supramolecular Engineering for Formamidinium‐Based Layered 2D Perovskite Solar Cells: Structural Complexity and Dynamics Revealed by Solid‐State NMR Spectroscopy

Milić

Kubicki

et al. 2019

Advanced Energy Materials

149

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“…Because adamantane has a highly symmetrical and rigid structure and can be isolated in larger amounts from the crude oil, researches on it are rapidly emerging [39][40][41][42][43][44][45][46][47][48]. Both experimental and theoretical studies show that adamantane molecules undergo self-assemble on metal surfaces or into molecular crystals in vacuum with high porosity [39][40][41][42][43][44][45][46]. Due to the high stability of the adamantane, the hydrogen molecule binding energy on such compound is so small that it is not suitable for reversible H 2 adsorption/desorption near room temperature for hydrogenstorage application [48].…”

mentioning

confidence: 99%

“…Diamondoids are hydrocarbons with cubic-diamond structures that can be used as potential chemical building blocks for new materials [38]. Because adamantane has a highly symmetrical and rigid structure and can be isolated in larger amounts from the crude oil, researches on it are rapidly emerging [39][40][41][42][43][44][45][46][47][48]. Both experimental and theoretical studies show that adamantane molecules undergo self-assemble on metal surfaces or into molecular crystals in vacuum with high porosity [39][40][41][42][43][44][45][46].…”

mentioning

confidence: 99%

Organometallic‐complex‐grafted adamantane as novel hydrogen‐storage material: A first principles computation

Zhang

Tang

et al. 2012

Physica Status Solidi (b)

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A novel type of hydrogen-storage materials C 10 H 16-m -(RTinH 2 ) m (m ¼ 1-4, n ¼ 1-5, R ¼ C 5 H 4 , C 6 H 5 ) was theoretically designed by grafting the organometallic complexes C 5 H 5 Ti and C 6 H 6 Ti onto the adamantane C 10 H 16 . The calculated binding energies of the organometallic complexes reveal that the grafting processes are exothermic and energetically favorable. Through this grafted pattern, the organometallic structures remain independent from each other, without clustering together as ''sandwich'' or ''rice-ball'' structures. The investigations of hydrogen adsorption on the grafted complexes indicate that the grafting processes do not affect the hydrogenadsorption capacity of the organometallic structures. With this method, the new complexes can store up to 6.50 wt% hydrogen when maximum numbers of H 2 molecules are adsorbed. Our study shows for the first time that adamantane functionalized by organometallic structures can be used as novel hydrogenstorage material.

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The Prognostic Role of Baseline Eosinophils in HPV-Related Cancers: a Multi-institutional Analysis of Anal SCC and OPC Patients Treated with Radical CT-RT

Rimini

Franco

Bertolini

et al. 2022

J Gastrointest Canc

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Background and Aim Anal squamous cell carcinoma (SCC) and oropharyngeal cancer (OPC) are rare tumors associated with HPV infection. Bioumoral predictors of response to chemoradiation (CT-RT) are lacking in these settings. With the aim to find new biomarkers, we investigated the role of eosinophils in both HPV-positive anal SCC and HPV-related oropharyngeal cancer (OPC). Methods We retrieved clinical and laboratory data of patients with HPV-positive anal SCC treated with CT-RT in 5 institutions, and patients with locally advanced OPC SCC treated with CT-RT in 2 institutions. We examined the association between baseline eosinophil count (the best cutoff has been evaluated by ROC curve analysis: 100 × 10^9/L) and disease-free survival (DFS). Unadjusted and adjusted hazard ratios by baseline characteristics were calculated using the Cox proportional hazards model. Results Three hundred four patients with HPV-positive anal SCCs and 168 patients with OPCs (122 HPV-positive, 46 HPV-negative diseases) were analyzed. In anal SCC, low eosinophil count (< 100 × 10^9/L) correlates to a better DFS (HR = 0.59; p = 0.0392); likewise, in HPV-positive OPC, low eosinophil count correlates to a better DFS (HR = 0.50; p = 0.0428). In HPV-negative OPC, low eosinophil count confers worse DFS compared to high eosinophil count (HR = 3.53; p = 0.0098). After adjustment for age and sex, eosinophils were confirmed to be independent prognostic factors for DFS (HR = 4.55; p = 0.0139). Conclusion Eosinophil count could be used as a prognostic factor in anal HPV-positive SCC. The worse prognosis showed in HPV-positive patients with high eosinophil count is likely to derive from an unfavorable interaction between the HPV-induced immunomodulation and eosinophils, which may hamper the curative effect of RT.

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A promising alternative anti-HBV agent: The targeted ribonuclease

Cited by 7 publications

References 34 publications

Supramolecular Engineering for Formamidinium‐Based Layered 2D Perovskite Solar Cells: Structural Complexity and Dynamics Revealed by Solid‐State NMR Spectroscopy

Supramolecular Engineering for Formamidinium‐Based Layered 2D Perovskite Solar Cells: Structural Complexity and Dynamics Revealed by Solid‐State NMR Spectroscopy

Organometallic‐complex‐grafted adamantane as novel hydrogen‐storage material: A first principles computation

The Prognostic Role of Baseline Eosinophils in HPV-Related Cancers: a Multi-institutional Analysis of Anal SCC and OPC Patients Treated with Radical CT-RT

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