A promising strategy for improved solubilization of ionic drugs simply by electrostatic pushing

Afzal, Mohd; Kundu, Pronab; Das, Sinjan; Ghosh, Saptarshi; Chattopadhyay, Nitin

doi:10.1039/c7ra08056e

Cited by 7 publications

(3 citation statements)

References 53 publications

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“…As for 20 wt % SDS (aq), two size distributions at 2 and 100 nm are observed, and the larger size distribution suggests the presence of micellar aggregates. 49,50 Upon the addition of acetone, the two peaks then vanished, implying that the structures of micelles and micellar aggregates of SDS have been destroyed.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

A Novel Hydrate Form of Sodium Dodecyl Sulfate and Its Crystallization Process

et al. 2021

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A novel hydrate form of sodium dodecyl sulfate (SDS) was firstly discovered through a hydrate screening with the use of organic solvents, while SDS is generally prepared solely in aqueous media. Surprisingly, a novel SDS hydrate form with needle-shaped crystals produced by adding acetonitrile to a 20 wt % SDS aqueous solution at a ratio of 3:1 (v/v) and further cooling to around 5 °C could be found with a trace amount in one of the two purchased SDS products that we examined. After comprehensive solid-state characterizations by powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA), Fourier transform infrared (FTIR), Raman spectroscopy, dynamic vapor sorption (DVS), and elemental analysis (EA), it is also successfully made directly from the synthesis of SDS through esterification and saponification. Four times the equal proportion of acetone was added into the reaction solution at an interval of 5 min to separate the side product, sodium sulfate, from the mother liquor. The desired novel hydrate form of SDS was then obtained by cooling the filtered mother liquor to 5 °C and aged for 8 h for a preferential growth.

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Section: ■ Results and Discussionmentioning

confidence: 99%

A Novel Hydrate Form of Sodium Dodecyl Sulfate and Its Crystallization Process

et al. 2021

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“…We select the SDS/NaCl/H 2 O system as micelles of this ubiquitous anionic surfactant increase in size with addition of salt. 35,36 Conventional batch DLS experiments require the preparation, handling and loading in a cuvette (∼1 mL) of numerous sample mixtures, which are measured sequentially. Employing a microfluidic mixer (Dolomite), we generate a composition library from two stock solutions, of 0.4 M SDS/0.2 M NaCl and 0.4 M SDS, imposing two symmetric flow rate ramps using a LabVIEW-controlled set of syringe pumps, depicted in Fig.…”

Section: Microfluidic-dls Scanning Of Surfactant Solution Compositionmentioning

confidence: 99%

“…We select the SDS/NaCl/H 2 O system as micelles of this ubiquitous anionic surfactant increase in size with addition of salt. 35,36…”

Section: Applicability and Limits Of Data Fitting Approachesmentioning

confidence: 99%

Microfluidic in-line dynamic light scattering with a commercial fibre optic system

et al. 2023

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Toxicity measurement and toxicity studies of drug delivery

Imran

Naqvi

Sherazi

et al. 2023

Novel Platforms for Drug Delivery Applications

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A promising strategy for improved solubilization of ionic drugs simply by electrostatic pushing

Abstract: Addition of soluble salts to the SDS-bound phenosafranin induces electrostatic pushing of the probe within the micellar interior from its initial location at the micelle–water interface.

Cited by 7 publications

References 53 publications

A Novel Hydrate Form of Sodium Dodecyl Sulfate and Its Crystallization Process

A Novel Hydrate Form of Sodium Dodecyl Sulfate and Its Crystallization Process

Microfluidic in-line dynamic light scattering with a commercial fibre optic system

Toxicity measurement and toxicity studies of drug delivery

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