A propensity-matched study of the effect of diabetes on the natural history of heart failure: variations by sex and age

Ahmed, Ali; Aban, Inmaculada; Vaccarino, Viola; Lloyd‐Jones, Donald M.; Goff, David C.; Zhao, Jianwen; Love, Thomas E.; Ritchie, Christine S.; Ovalle, Fernando; Gambassi, Giovanni; Dell’Italia, Louis J.

doi:10.1136/hrt.2006.113522

Cited by 51 publications

(68 citation statements)

References 31 publications

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“…Many researchers have used this method in studies of hypertension-related chronic diseases. [33][34][35][36] Statistical analysis. We compared the sample characteristics of patients with hypertension with those of patients without hypertension, before and after the propensity score matching, using the χ 2 test for categorical variables and the Wilcoxon two-sample test for continuous variables.…”

Section: Resultsmentioning

confidence: 99%

Hospitalization Costs Associated With Hypertension as a Secondary Diagnosis Among Insured Patients Aged 18-64 Years

Wang

Zhang

Ayala

2010

American Journal of Hypertension

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Section: Resultsmentioning

confidence: 99%

Hospitalization Costs Associated With Hypertension as a Secondary Diagnosis Among Insured Patients Aged 18-64 Years

Wang

Zhang

Ayala

2010

American Journal of Hypertension

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“…10,19,20 Obesity is a major risk factor for diabetes mellitus, which is prevalent among heart failure patients. 1,21 A recent subanalysis of a trial from the 1990s, the Digitalis Investigation Group (DIG) study, in a population with chronic heart failure, suggests that obesity confers no survival benefit in heart failure patients with diabetes mellitus. 22 We aimed to evaluate the long-term prognostic impact of BMI according to diabetes mellitus history in a real world community population of chronic systolic heart failure patients followed in a specialized heart failure clinic of a tertiary care academic hospital.…”

Section: Introductionmentioning

confidence: 99%

Higher BMI in heart failure patients is associated with longer survival only in the absence of diabetes

Pinho

Lourenço

Silva

et al. 2015

Journal of Cardiovascular Medicine

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“…Our finding is consistent with prior analyses of the Danish Investigations of Arrhythmia and Mortality on Dofetilide-HF and the Digitalis Investigation Group trials, which also identified an interaction between diabetes and sex in patients with HF. 4,17 In Danish Investigations of Arrhythmia and Mortality on Dofetilide-HF, diabetes (present in 900 of 5491 patients randomized) was associated with a greater risk of death in women than in men, with relative risks of 1.7 (1.4 to 1.9) and 1. 18,19 and the explanation for this may be multifactorial in origin.…”

Section: Long-term Outcomes: the Interaction Between Diabetes And Sexmentioning

confidence: 99%

Discordant Short- and Long-Term Outcomes Associated With Diabetes in Patients With Heart Failure: Importance of Age and Sex

MacDonald

Jhund

Petrie

et al. 2008

Circ: Heart Failure

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Background-Diabetes and heart failure frequently coexist. Our aim was to assess the association between diabetes and short-and long-term outcomes in all patients admitted to the hospital for the first time with heart failure in Scotland between 1986 and 2003. Methods and Results-A total of 116 556 patients were studied, of whom 13% (nϭ15 161) had a diagnosis of diabetes.At 30 days, diabetes was associated with a lower case fatality. By 1 year, the association between diabetes and better outcome was reversed, and diabetes was a significant independent predictor of higher case fatality. The longer term risk of death associated with diabetes was greatest in younger patients. In patients aged 65 years or younger, the hazard ratio for mortality at 5 years associated with diabetes was 1.41 (95% CI, 1.31 to 1.52) for men and 1.64 (1.50 to 1.79) for women. The risk associated with diabetes was less in patients aged 75 years or older: a hazard ratio in men 1.16 (1.10 to 1.22) and in women 1.15 (1.10 to 1.20). In the younger age group the risk associated with diabetes was significantly greater in women than in men (Pϭ0.005 for diabetes-sex interaction). Diabetes was also a significant independent predictor of heart failure readmission, and again the risk was greatest in younger women. Conclusions-Although diabetes was associated with a lower case fatality at 30 days, by 1 year it was a significant independent predictor of higher case fatality. The risk associated with diabetes was greatest in young patients, and in young patients the risk was greatest in women. (Circ Heart Fail. 2008;1:234-241.)

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A propensity-matched study of the effect of diabetes on the natural history of heart failure: variations by sex and age

Abstract: Diabetes-associated increases in morbidity and mortality in chronic HF were more pronounced in women, and theses sex-related differences in outcomes were primarily observed in elderly patients.

Cited by 51 publications

References 31 publications

Hospitalization Costs Associated With Hypertension as a Secondary Diagnosis Among Insured Patients Aged 18-64 Years

Hospitalization Costs Associated With Hypertension as a Secondary Diagnosis Among Insured Patients Aged 18-64 Years

Higher BMI in heart failure patients is associated with longer survival only in the absence of diabetes

Discordant Short- and Long-Term Outcomes Associated With Diabetes in Patients With Heart Failure: Importance of Age and Sex

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