A propensity-matched study of the association between pre-pregnancy maternal underweight and perinatal outcomes of singletons conceived through assisted reproductive technology

Qu, Pengfei; Liu, Fangfang; Zhao, Doudou; Wang, Yongbo; Wang, Min; Wang, Linyu; Dang, Shaonong; Wang, Duolao; Shi, Juanzi; Shi, Wenhao

doi:10.1016/j.rbmo.2019.06.007

Cited by 9 publications

(8 citation statements)

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“…Furthermore, we investigated the impact of pre-pregnancy maternal underweight on birth outcomes among ART-conceived singletons in a previous retrospective cohort. An interaction was found between maternal underweight and timing of embryo transfer (fresh/frozen embryo transfer) on gestational age (underweight vs. normal weight: fresh: difference = −0.07 week, 95% CI: −0.22 to 0.09 week; frozen: difference = 0.15 week, 95% CI: −0.05 to 0.36 week; P for interactio n = 0.038) ( 25 ). In our study, we found a significant interaction between pre-pregnancy maternal BMI and timing of embryo transfer (fresh/frozen embryo transfer) on PTB and LGA in ART-conceived singletons.…”

Section: Discussionmentioning

confidence: 99%

“…Based on the literature (24,25), we collected all potential correlated factors of perinatal outcomes from the records. These include the year of embryo transfer (2006-2009, 2010-2012, or 2013-2015), maternal age, gravidity (0, 1-2, or, ≥3), parity (0 or ≥1), main etiology of infertility (tubal factor, ovarian factor, male factor, or other reasons), sperm donation (yes or no), fertilization method (ICSI, IVF, or IVF + ICSI), fresh/frozen embryo transfer, blastocyst/cleavage-stage transfer, assisted hatching (yes or no), antral follicle count, basal serum follicle-stimulating hormone (FSH) level, endometrial thickness, maternal smoking history (yes or no), and gestational weight gain.…”

Section: Confounding Variablesmentioning

confidence: 99%

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Effect of the Interaction Between Pre-pregnancy Body Mass Index and Fresh/Frozen Embryo Transfer on Perinatal Outcomes of Assisted Reproductive Technology-Conceived Singletons: A Retrospective Cohort Study

Zhao

et al. 2020

Front. Endocrinol.

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Section: Discussionmentioning

confidence: 99%

Section: Confounding Variablesmentioning

confidence: 99%

Effect of the Interaction Between Pre-pregnancy Body Mass Index and Fresh/Frozen Embryo Transfer on Perinatal Outcomes of Assisted Reproductive Technology-Conceived Singletons: A Retrospective Cohort Study

Zhao

et al. 2020

Front. Endocrinol.

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“…Moreover, epidemiological studies have been suggested that maternal overweight and obesity have been shown to be association with PTB (Lynch et al 2014;Shaw et al 2014;Su et al 2020), LBW (Rahman et al 2015) and adverse maternal health Manuscript to be reviewed outcomes, such as gestational hypertension (Santos et al 2019) and cesarean delivery (Paidas Teefey et al 2020;Rahman et al 2015). Similarly, several observational studies show that underweight women in pre-pregnancy is the major risk factor for LBW and PTB (Ehrenberg et al 2003;Madzia et al 2020;Qu et al 2019). However, the conclusions of various studies on the correlation between pre-pregnancy BMI and PTB appear to be paradoxical.…”

Section: Introductionmentioning

confidence: 99%

Peer Review #1 of "Association of pre-pregnancy body mass index with adverse pregnancy outcome among first-time mothers (v0.1)"

2020

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Background: Studies have reported an increased risk of adverse pregnancy outcome associated with pre-pregnancy body mass index (BMI). However, the data on such associations in urban areas of southern Chinese women is limited, which drive us to clarify the associations of pre-pregnancy BMI and the risks of adverse pregnancy outcomes (preterm birth (PTB) and low birth weight (LBW)) and maternal health outcomes (gestational hypertension and cesarean delivery). Methods: We performed a hospitalbased case-control study including 3,864 Southern Chinese women who gave first birth to a live singleton infant from January 2015 to December 2015. PTB was stratified into three subgroups according to gestational age (extremely PTB, very PTB and moderate PTB).Besides, we combined birth weight and gestational age to dichotomise as being small for gestational age (SGA, less than the tenth percentile of weight for gestation) and non-small for gestational age (NSGA, large than the tenth percentile of weight for gestation), gestational week was also classified into categories of term, 34-36 week and below 34 week.. We then divided newborns into six groups: (1) term and NSGA; (2) 34-36 week gestation and NSGA; (3) below 34 week gestation and NSGA; (4) term and SAG; (5) 34-36 week gestation and SAG; (6) below 34 week gestation and SAG. Adjusted logistic regression models was used to estimate the odds ratios of adverse outcomes. Results:Underweight women were more likely to give LBW (AOR=1.44, 95% CI 1.11 to 1.89), the similar result was seen in term and SAG as compare with term and NSAG (AOR=1.78, 95% CI 1.45-2.17). Whereas underweight was significantly associated with a lower risk of gestational hypertension (AOR=0.45, 95% CI 0.25-0.82) and caesarean delivery (AOR=0.74, 95% CI 0.62-0.90). The risk of extremely PTB is relatively higher among overweight and obese mothers in a subgroup analysis of PTB (AOR=8.12, 95% CI=1.11 to

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“…Moreover, epidemiological studies have been suggested that maternal overweight and obesity have been shown to be association with PTB (Lynch et al, 2014;Shaw et al, 2014;Su et al, 2020), LBW (Rahman et al, 2015) and adverse maternal health outcomes, such as gestational hypertension (Santos et al, 2019) and cesarean delivery (PaidasTeefey et al, 2020;Rahman et al, 2015). Similarly, several observational studies show that underweight women in pre-pregnancy is the major risk factor for LBW and PTB (Ehrenberg et al, 2003;Madzia et al, 2020;Qu et al, 2019). However, the conclusions of various studies on the correlation between pre-pregnancy BMI and PTB appear to be paradoxical.…”

Section: Introductionmentioning

confidence: 99%

Association of pre-pregnancy body mass index with adverse pregnancy outcome among first-time mothers

Chen

Lin

et al. 2020

PeerJ

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Background Studies have reported an increased risk of adverse pregnancy outcome associated with pre-pregnancy body mass index (BMI). However, the data on such associations in urban areas of southern Chinese women is limited, which drive us to clarify the associations of pre-pregnancy BMI and the risks of adverse pregnancy outcomes (preterm birth (PTB) and low birth weight (LBW)) and maternal health outcomes (gestational hypertension and cesarean delivery). Methods We performed a hospital-based case-control study including 3,864 Southern Chinese women who gave first birth to a live singleton infant from January 2015 to December 2015. PTB was stratified into three subgroups according to gestational age (extremely PTB, very PTB and moderate PTB). Besides, we combined birth weight and gestational age to dichotomise as being small for gestational age (SGA, less than the tenth percentile of weight for gestation) and non-small for gestational age (NSGA, large than the tenth percentile of weight for gestation), gestational week was also classified into categories of term, 34-36 week and below 34 week.. We then divided newborns into six groups: (1) term and NSGA; (2) 34–36 week gestation and NSGA; (3) below 34 week gestation and NSGA; (4) term and SAG; (5) 34–36 week gestation and SAG; (6) below 34 week gestation and SAG. Adjusted logistic regression models was used to estimate the odds ratios of adverse outcomes. Results Underweight women were more likely to give LBW (AOR = 1.44, 95% CI [1.11–1.89]), the similar result was seen in term and SAG as compared with term and NSAG (AOR = 1.78, 95% CI [1.45–2.17]), whereas underweight was significantly associated with a lower risk of gestational hypertension (AOR = 0.45, 95% CI [0.25–0.82) and caesarean delivery (AOR = 0.74, 95% CI [0.62–0.90]). The risk of extremely PTB is relatively higher among overweight and obese mothers in a subgroup analysis of PTB (AOR = 8.12, 95% CI [1.11–59.44]; AOR = 15.06, 95% CI [1.32–172.13], respectively). Both maternal overweight and obesity were associated with a greater risk of gestational hypertension (AOR = 1.71, 95% CI [1.06–2.77]; AOR = 5.54, 95% CI [3.02–10.17], respectively) and caesarean delivery (AOR = 1.91, 95% CI [1.53–2.38]; AOR = 1.85, 95% CI [1.21–2.82], respectively). Conclusions Our study suggested that maternal overweight and obesity were associated with a significantly higher risk of gestational hypertension, caesarean delivery and extremely PTB. Underweight was correlated with an increased risk of LBW and conferred a protective effect regarding the risk for gestational hypertension and caesarean delivery for the first-time mothers among Southern Chinese.

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A propensity-matched study of the association between pre-pregnancy maternal underweight and perinatal outcomes of singletons conceived through assisted reproductive technology

Abstract: A propensity-matched study of the association between prepregnancy maternal underweight and perinatal outcomes among singletons based on an ART cohort,

Cited by 9 publications

References 45 publications

Effect of the Interaction Between Pre-pregnancy Body Mass Index and Fresh/Frozen Embryo Transfer on Perinatal Outcomes of Assisted Reproductive Technology-Conceived Singletons: A Retrospective Cohort Study

Effect of the Interaction Between Pre-pregnancy Body Mass Index and Fresh/Frozen Embryo Transfer on Perinatal Outcomes of Assisted Reproductive Technology-Conceived Singletons: A Retrospective Cohort Study

Peer Review #1 of "Association of pre-pregnancy body mass index with adverse pregnancy outcome among first-time mothers (v0.1)"

Association of pre-pregnancy body mass index with adverse pregnancy outcome among first-time mothers

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