2013
DOI: 10.1378/chest.12-0750
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A Proposal for Combination of Total Number and Anatomical Location of Involved Lymph Nodes for Nodal Classification in Non-small Cell Lung Cancer

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Cited by 87 publications
(72 citation statements)
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“…Despite substantial data that the eradication of tumor from mediastinal lymph nodes is strongly associated with overall survival, the prognostic value of lymph node burden both at initial diagnosis and after induction chemoradiation is less clear [1114]. Alexander et al reported a significant association between increased lymph node volume and decreased survival [15], however Dehing-Oberije et al demonstrated a lack of association between lymph node size and survival [13].…”
Section: Introductionmentioning
confidence: 99%
“…Despite substantial data that the eradication of tumor from mediastinal lymph nodes is strongly associated with overall survival, the prognostic value of lymph node burden both at initial diagnosis and after induction chemoradiation is less clear [1114]. Alexander et al reported a significant association between increased lymph node volume and decreased survival [15], however Dehing-Oberije et al demonstrated a lack of association between lymph node size and survival [13].…”
Section: Introductionmentioning
confidence: 99%
“…Thirty-three were T1 and 60 were T2. We resected a median number of 6 lymph node stations (lower quartile and upper quartile, 4-8) and 15 nodes per patient (lower quartile and upper quartile, [11][12][13][14][15][16][17][18][19][20]; in detail, 6 (lower quartile and upper quartile 4-7) were hilar nodes and 9 (lower quartile and upper quartile 6-14) were mediastinal nodes.…”
Section: Resultsmentioning
confidence: 99%
“…[9] compared 4 proposed lymph node staging systems [7,[18][19][20] (based on the metastatic nodal zone, number of lymph nodes involved, lymph node ratio and combination of the number and location of metastatic lymph nodes) and found no significant difference among them in terms of predictive power using the C-index, but they found a higher C-index value for the classification based on the number of metastatic lymph nodes. This evidence should be used to complete the current nodal staging system rather than radically change it.…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, other authors reported the possibility of the number of involved nodes instead of the locationbased cN or pN in lung cancer (10,11). These studies compared the two categorizations, by location and number of metastatic nodes and showed that the number of involved nodes is a better prognostic determinant than the locationbased pN classification.…”
Section: Editorialmentioning
confidence: 99%