A proposal for the stratification of the risk of locoregional failure after surgical resection, perioperative high dose rate brachytherapy, and external beam irradiation: The University of Navarre predictive model

Endoscopy-guided brachytherapy for sinonasal and nasopharyngeal recurrences

“…In the literature, there is also evidence that the risk of locoregional failure after surgical resection, external beam irradiation, and perioperative high-dose BT can be accurately stratified according to the number of residual clonogens and the initial size of the tumor mass, which appear to be the two most relevant factors to predict the failure (31).…”

Perioperative high dose rate brachytherapy in head and neck cancers: case report and review of clinical application

“… 10 To help patient selection, the University of Navarre predictive model can also be used which divides patients into low risk, intermediate, high and very high risk categories. 11 Preplanning with the surgical team is useful and should also review the reconstruction procedure and type of surgical flaps to be used. Identifying the feeding vasculature for the surgical flap can prevent unintended irradiation to the flap vasculature and have implications on flap viability.…”

Perioperative HDR Brachytherapy for Reirradiation in Head and Neck Recurrences: Single-institution Experience and Systematic Review

“…Other authors have even proposed to stratify the risk of locoregional failure after surgical resection, EBRT and perioperative high-dose brachytherapy according to the number of residual clonogens and the initial size of the tumor mass, which appear to be the 2 most relevant factors to predict treatment failure (32).…”