A Proposed Insight into the Anti-viral Potential of Silver Nanoparticles against Novel Coronavirus Disease (COVID-19)

Магомедов, М. А.; Shebzukhov, Nuri Ruslanovich; Timerbulatova, Tabarik Rustamovna; Amrakhov, Elvin Makhir ogly; Adzhieva, Madina Elbrusovna; Murdalov, Rizvan Abdievich; Ilbekov, Rustem Khamidovich; Batalova, Hava Ilyasovna; Isaeva, Makka Magomedovna; Ibragimov, Alikhan Magomedgadzhievich; Povetkin, Sergey Nikolaevich

doi:10.9734/jpri/2021/v33i41b32347

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…Moreover, the most stable complex was the "cysteine-SNPs" complex (Delta E = 0.16 a.u.). Therefore, they concluded that SNPs could exert antiviral activity through the interaction with tryptophan and cysteine amino acids of the coronavirus spike proteins (54). Other studies also reported similar results about SNP's antiviral activity (55)(56)(57).…”

Section: Resultsmentioning

confidence: 74%

Fabrication of Silver Nanoparticles-deposited Fabrics as A Potential Candidate for The Development of Reusable Facemask and Evaluation of Their Performance

Abazari

Badeleh

Khaleghi

et al. 2022

Preprint

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Recently, wearing facemasks in public has been raised due to the coronavirus disease 2019 epidemic worldwide. However, the performance and effectiveness of many existing products have raised significant concerns among people and professionals. In this respect, doping or impregnating facemask fabrics with metallic substances or nanoparticles like silver nanoparticles has been proposed. Therefore, in the present study, we aimed to sonochemically deposit silver nanoparticles on the non-woven Spunbond substrates at different sonication times and concentrations to develop reusable antibacterial and antiviral facemask for protection against coronavirus. The coated substrates were characterized in terms of morphological, mechanical, and functional characteristics. The results confirmed high and uniform deposition of silver nanoparticles on Spunbond fabrics with desirable stability and mechanical properties. Evaluation of functional characteristics of the resultant fabrics showed suitable particle filtration efficiency, pressure drop, and electrical conductivity, which are essential elements for a desired facemask with enhanced protection and support of normal breath. The prepared fabrics also showed high antibacterial activity against E. coli and S. aureus bacteria without any significant cytotoxicity effect toward HEK 293 cells and brine shrimp.

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Section: Resultsmentioning

confidence: 74%

Fabrication of Silver Nanoparticles-deposited Fabrics as A Potential Candidate for The Development of Reusable Facemask and Evaluation of Their Performance

Abazari

Badeleh

Khaleghi

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Moreover, the most stable complex was the "cysteine-SNPs" complex (Delta E = 0.16 a.u.). Therefore, they concluded that SNPs could exert antiviral activity through the interaction with tryptophan and cysteine amino acids of the coronavirus spike proteins 66 . Other studies also reported similar results about SNP’s antiviral activity 67 – 69 .…”

Section: Resultsmentioning

confidence: 99%

Fabrication of silver nanoparticles-deposited fabrics as a potential candidate for the development of reusable facemasks and evaluation of their performance

Abazari

Badeleh

Khaleghi

et al. 2023

Sci Rep

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Recently, wearing facemasks in public has been raised due to the coronavirus disease 2019 epidemic worldwide. However, the performance and effectiveness of many existing products have raised significant concerns among people and professionals. Therefore, greater attempts have been focused recently to increase the efficacy of these products scientifically and industrially. In this respect, doping or impregnating facemask fabrics with metallic substances or nanoparticles like silver nanoparticles has been proposed. So, in the present study, we aimed to sonochemically coat silver nanoparticles on the non-woven Spunbond substrates at different sonication times and concentrations to develop antibacterial and antiviral facemask. The coated substrates were characterized using Field Emission Scanning Electron Microscope, Energy Dispersive X-Ray, X-ray diffraction, and Thermogravimetry analysis. The amount of silver released from the coated substrates was measured by atomic absorption spectroscopy. The filtration efficiency, pressure drop, and electrical conductivity of the coated samples were also investigated. The antibacterial activity of fabrics was evaluated against Escherichia coli and Staphylococcus aureus. Cellular viability of samples assessed by MTT and brine shrimp lethality tests. The results revealed that the higher sonication times and precursor concentrations result in a higher and more stable coating, larger particle size, wider particle size distribution, and lower content of released silver. Coated fabrics also revealed enhanced filtration efficiency (against nanosize particles), desired pressure drop, and antibacterial activity without significant cytotoxicity toward HEK 293 cells and Artemia nauplii. As a result, the coated fabrics could find potential applications in the development of facemasks for protection against different pathogenic entities.

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“…The treatment of pregnant women infected with COVID-19 required special attention (Magomedov et al, 2021;Mishununa et al, 2021). It was necessary to find a way to treat pregnant patients without harm to the fetus.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Treatment of Pregnant Women with COVID-19 Using the Drug Baricitinib

Salbieva¹,

Cheldieva²,

Plieva³

et al. 2022

J Biochem Technol

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This article discusses the complexities and various aspects related to the treatment of pregnant women with COVID-19. The experience of Chinese doctors who were the first to face this problem is considered, and a new method of treating the disease using the drug Baricitinib is also considered. Baricitinib is an anti-inflammatory drug, a representative of the Janus kinase class, used in the treatment of rheumatoid arthritis. It blocks intracellular signaling pathways, which leads to the regulation of the synthesis of interleukins 2, 6, 10, and interferon-gamma. The drug is licensed for the treatment of rheumatoid arthritis, has good efficacy and safety indicators. Attention was paid to the doses and modes of use of baricitinib. The article discusses a study conducted by Chinese doctors. The study involved 34 infected pregnant women, of whom half were offered standard treatment and the other half standard treatment with baricitinib. In order to have a complete picture that allows us to conclude that this method of treatment is ineffective or effective, it is necessary to continue monitoring patients who took baracitinib in the treatment of COVID-19.

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A Proposed Insight into the Anti-viral Potential of Silver Nanoparticles against Novel Coronavirus Disease (COVID-19)

Cited by 5 publications

References 13 publications

Fabrication of Silver Nanoparticles-deposited Fabrics as A Potential Candidate for The Development of Reusable Facemask and Evaluation of Their Performance

Fabrication of Silver Nanoparticles-deposited Fabrics as A Potential Candidate for The Development of Reusable Facemask and Evaluation of Their Performance

Fabrication of silver nanoparticles-deposited fabrics as a potential candidate for the development of reusable facemasks and evaluation of their performance

Evaluation of the Treatment of Pregnant Women with COVID-19 Using the Drug Baricitinib

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