A prospective clinical study of an Ayurveda regimen in COVID 19 patients

Wanjarkhedkar, Pankaj; Sarade, Girish; Purandare, Bharat; Kelkar, Dhananjay

doi:10.1016/j.jaim.2020.10.008

Cited by 33 publications

(29 citation statements)

References 9 publications

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“…Ayurveda findings are similar to recently published results of a study demonstrating that the Ayurveda combination appeared to accelerate recovery of patients hospitalized for COVID 19 infection, in terms of reduction of symptoms and duration of hospital stay. 30 Our preliminary results also suggest a similar effect of the combination of Ayurveda to prevent severe respiratory tract infections when administrated to patients suffering from viral infection. Further studies on this combination are needed, since such combination may both act as an antiviral therapy against SARS-CoV-2 and prevent bacterial super-infections.…”

Section: Efficacy Outcomessupporting

confidence: 63%

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A Community-Based Participatory Research to Assess the Feasibility of Ayurveda Intervention in Patients with Mild-to-Moderate COVID-19

Kulkarni

Sharma

et al. 2021

Preprint

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Innovative strategies are required to manage COVID-19 in the communities. Back to Roots was a collaborative, community-based pilot intervention project in the British Asian community. To assess the efficacy and safety of Ayurveda intervention in relieving symptoms of mild-to-moderate COVID-19, a community based participatory research framework was used. Prospectively 28 patients were enrolled with confirmed COVID-19 clinical stages of mild-to-moderate COVID-19, symptomatic, and between 20 to 70□years of age. Routine management was followed by all patients managing at home, additionally patents taking Ayurveda intervention for 14 consecutive days. The efficacy and safety of Ayurveda intervention were evaluated. There were suggestions of Ayurveda’s advantage in improved symptoms relief, clinical recovery in 7 days. However, a control group was not included but data triangulations from separate usual care found the difference statistically significant. Ayurveda intervention may potentially have a beneficial effect on patients with COVID□19, especially for those with mild to moderate symptoms. A further definitive large□scale clinical trial is necessary.

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Section: Efficacy Outcomessupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

A Community-Based Participatory Research to Assess the Feasibility of Ayurveda Intervention in Patients with Mild-to-Moderate COVID-19

Kulkarni

Sharma

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…In another docking study 6 gingesulphonic acid which is present in Sunthi (Zingiber officinale Roscoe) showed higher binding energy and inhibition to protein molecule of SARS-CoV-2 compared to hydroxychloroquine and quinine [ 17 ]. In a Prospective clinical study comprising Daśmūlakaṭtrayādi kaṣāya and Guḍūcyādi kvātha tablets as add on to standard care showed a faster recovery from breathlessness with reduced ageusia and accelerate recovery in terms of reduction of symptoms and duration of hospital stay [ 18 ].…”

Section: Potential Role Of Ayurveda and Yoga In Covid-19 Infection: Current Evidence Basementioning

confidence: 99%

Role of Ayurveda and Yoga-Based lifestyle in the COVID-19 pandemic – A narrative review

Chikkanna

Ramakrishna

Jasti

et al. 2022

Journal of Ayurveda and Integrative Medicine

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The COVID-19 pandemic has posed an immense challenge to health care systems around the globe in terms of limited health care facilities and proven medical therapeutics to address the symptoms of the infection. The current health care strategies have primarily focused on either the pathogen on the environmental factors. However, efforts towards strengthening the host immunity are important from public health perspective to prevent the spread of infection and downregulate the potency of the agent. While a vaccine can induce specific immunity in the host, non-specific ways of improving overall host immunity are the need. This scenario has paved the way for the use of traditional Indian therapies such as Ayurveda and Yoga. This review aims at collating available evidence on Ayurveda, Yoga and COVID-19. Further, it draws inferences from recent studies on Yoga and Ayurveda on immunity, respiratory health and mental health respectively to approximate its probable role in prophylaxis and as an add-on management option for the current pandemic.

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“…More recently, there are reports of the use of Ayurveda for prophylaxis as well as treatment of In an open-label randomized controlled trial performed on COVID patients with mild to moderate symptoms in a tertiary care facility [45], the Ayurvedic medicines Dasamoolkaduthrayam Kashaya and Guluchyadi Kwatham (in tablet form) were administered as adjunct to the Standard of Care treatment to the treatment group; the Ayurvedic regime was observed to have fastened recovery in terms of reduction of symptoms (particularly breathlessness) as well as duration of stay in hospital. In another randomized controlled trail [40] that used the Ayurvedic medicine Guduchi Ghan Vati in addition to the standard treatment for asymptomatic COVID patients, all the patients in the intervention group continued to remain asymptomatic while 11.7% of those in the control group developed mild symptoms; moreover, significant differences between the two groups were observed in terms of duration of hospital stay as well as virologic clearance on days 7 and 14.…”

Section: Introductionmentioning

confidence: 99%

Integrative Therapy based on Yoga, Ayurveda and Modern Western Medicine for Treatment of High-risk Cases of COVID-19: A Telemedicine-Based Case Series

Bentur¹,

Mishra²,

Kumar³

et al. 2021

Preprint

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Background: We report a telemedicine-based case-series of thirty high risk COVID-19 positive patients with co-morbidities such as Diabetes Mellitus (DM), Hypertension (HTN), Hypothyroidism, Ulcerative Colitis and Chronic Kidney Disease (CKD) or aged 60 and above (or possibly both), treated successfully using an Integrative Therapy plan based on Ayurveda, Yoga and Modern Western Medicine. The symptoms experienced by the patients included fever, body-ache, sore throat/throat pain, cough/running nose, headache, nasal/chest congestion, stomach problems (such as diarrhea, constipation), nausea, loss of taste, loss of smell, foul smell or taste, loss of appetite, weakness, gastric upset, respiratory trouble (such as breathlessness or high respiration rate) and anxiety. Two patients (both aged above 70) were asymptomatic and remained asymptomatic during the entire course of the treatment. Design: The reported cases have been categorized into YAS (patients taking Yoga and Ayurveda based treatment, with possibly western Supplements), YASP (patients taking Yoga and Ayurveda based treatment, with possibly western Supplements and Paracetamol), YAM (patients taking Yoga and Ayurveda based treatment, and Modern western medicine (MWM) as an adjunct), MYA (patients who first tried the Modern western medicines (in most of the cases mandated by the government) and later switched to Yoga and Ayurveda treatment. The last group has been further subdivided into subgroups – patients who developed new symptoms after the commencement of Yoga and Ayurveda-based treatment (MYA-S) and those who did not (MYS-NS). The YAS group had 4 patients, YASP had 6 patients, YAM had 6 and MYA had 14 patients (MYA-S having 7 and MYA-NS having 7). Case-Series Presentation: Ayurveda is a highly personalized system of medicine that considers the Prakruti (the Ayurvedic constitution) as well as Vikruti (the homeostatic imbalances) in treating the patients. Based on the patient's symptoms and co-morbidities, a personalized treatment plan including Ayurvedic medicines, Yoga protocol, dietary recommendations and lifestyle modifications was prescribed by a registered Ayurveda doctor and a Yoga consultant. More than half of the symptomatic patients started experiencing improvement within 5 days (90% within 9 days) from the start of the treatment. More than 60% of the symptomatic patients reported at least 90% recovery within 10 days (90% within 17 days) from the start of the treatment. Six patients, whose SpO2 level was observed to be at or below 95%, benefited from the practice of Makarasana and Shithilasana. None of the patients progressed to severe stage of illness. Many patients experienced improvement with respect to their comorbidities besides COVID-related symptoms. Some of them, after recovering from COVID, even sought consultation for long-term management of their comorbidities through Ayurveda and Yoga. Some patients got so convinced about the possibility of restoration of health through Yoga, that they adopted this practice into their lifestyle.Conclusions: The Integrative Therapy was found to be very effective in mitigating the symptoms of all the high-risk cases of COVID-19 patients with comorbidities who remained compliant to the treatment. Considering that approximately 32.8% of the patients with the comorbidities such as DM, HTN, COPD, cardiovascular disease, cerebrovascular disease, chronic kidney disease, Hepatitis B, malignancy, immunodeficiency progress to severe stage of illness, and assuming under the null hypothesis that a similar percentage of patients are expected to progress to a severe stage for the treatment population, the corresponding p-value (incorporating 23 symptomatic patients with one or more of the above comorbidities) turns out to be 1.07 x10^-4. Integrative Therapy based on classical texts of Ayurveda and Yoga from the East and emergency treatment of modern western medicine may offer a promising and scalable treatment option for COVID-19 patients. More studies including a suitably designed randomized controlled trial is needed to assess its efficacy.

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A prospective clinical study of an Ayurveda regimen in COVID 19 patients

Cited by 33 publications

References 9 publications

A Community-Based Participatory Research to Assess the Feasibility of Ayurveda Intervention in Patients with Mild-to-Moderate COVID-19

A Community-Based Participatory Research to Assess the Feasibility of Ayurveda Intervention in Patients with Mild-to-Moderate COVID-19

Role of Ayurveda and Yoga-Based lifestyle in the COVID-19 pandemic – A narrative review

Integrative Therapy based on Yoga, Ayurveda and Modern Western Medicine for Treatment of High-risk Cases of COVID-19: A Telemedicine-Based Case Series

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