A prospective comparative observational study of clinical efficacy of isobaric ropivacaine 0.75% with of isobaric bupivacaine 0.5% intrathecally in elective inguinal hernia repair surgeries

Parekh, Shivam Bipin; Parikh, Suchita Shailesh; Patel, Harsha; Mehta, Malini

doi:10.4103/aer.aer_105_17

Cited by 4 publications

(7 citation statements)

References 9 publications

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“…The faster home discharge in Group R might be due to the shorter duration of sensory block and faster regression to S5. This is similar to the finding in the study conducted by Parekh et al [23] comparing 0.75% isobaric ropivacaine with 0.5% isobaric bupivacaine spinal anaesthesia in elective inguinal hernia. It was found that patients in the Ropivacaine group achieved faster home discharge compared to those in the Bupivacaine group.…”

Section: Parameterssupporting

confidence: 91%

Saddle Block for Transrectal Prostate Biopsy: A Comparison of the Analgesic Efficacy of 0.25% Bupivacaine and 0.375% Ropivacaine

Bamigboye¹,

Olateju²,

Faponle³

et al. 2021

Ann Health Res

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Background: Prostate biopsy is a painful procedure, and the degree of pain is related to the number of core biopsies taken. Objective: To compare the analgesic properties of hyperbaric bupivacaine 0.25% with 0.375% ropivacaine for saddle block in transrectal prostate biopsy. Methods: This was a randomised double-blinded study. Eighty patients with indications for prostate biopsy presenting at the Day-Case Theatre in a Nigerian tertiary facility were randomised into two equal groups: B (Bupivacaine) and R (Ropivacaine). Group B received 1ml of 0.25% bupivacaine, while Group R received 1ml of 0.375% ropivacaine for saddle block, respectively. Pain assessment, home readiness, patients' satisfaction, and time to first analgesic request were assessed and compared between the two groups. Results: The Bupivacaine group had an earlier onset of sensory block (11.90±4.10 minutes vs 23.70±8.65 minutes, p = 0.000), slower sensory block regression (48.73±9.32 minutes vs 24.88±4.21 minutes, p = 0.000), but delayed home readiness (47.23±15.93 minutes vs 29.88±8.58 minutes, p = 0.000), than patients in the Ropivacaine group. The pain scores during, immediately after and 30 minutes post-biopsy were lower in the Bupivacaine group: p = 0.010, p = 0.028 and p = 0.023 respectively. The time to first analgesic request was also longer in the Bupivacaine group (48.73±9.33 minutes) than for those in the Ropivacaine group (24.88±4.21 minutes) with statistical significance (p = 0.000). Conclusion: Intraoperative analgesic properties were better in the Bupivacaine group than in the Ropivacaine group. However, home readiness was earlier in the Ropivacaine group.

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Section: Parameterssupporting

confidence: 91%

Saddle Block for Transrectal Prostate Biopsy: A Comparison of the Analgesic Efficacy of 0.25% Bupivacaine and 0.375% Ropivacaine

Bamigboye¹,

Olateju²,

Faponle³

et al. 2021

Ann Health Res

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“… 2 However, side-effects of bupivacaine, such as bradycardia, hypotension, motor paralysis, and cardiac and central nervous system toxicity, have also been reported, which have led to the search for alternatives with better properties such as short and rapid action with minimal side-effects. 3 4 5 6 7 …”

Section: Introductionmentioning

confidence: 99%

Isobaric forms of ropivacaine vs. bupivacaine in lower abdominal surgeries

Patil

Dhulkhed

2023

Medical Gas Research

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We aimed to assess whether ropivacaine (0.75%; 22.5 mg) can replace bupivacaine (0.5%; 15 mg) as a better intrathecal anesthetic in lower abdominal surgery. In this hospital-based, single-blind, randomized, prospective, comparative study, 100 patients of either sex, aged between 18 and 70 years, weighing 40-80 kg, with American Society of Anesthesiologists physical status 1 and 2, and undergoing lower abdominal surgery were randomly allocated into two groups to receive intrathecal isobaric bupivacaine 0.5% 3 mL (15 mg) or ropivacaine 0.75% 3 mL (22.5 mg). In the intraoperative period, the onset, efficacy, duration, and regression of sensory and motor blockade and the quality of anesthesia and hemodynamic effects were observed at regular intervals. The ropivacaine and bupivacaine groups were comparable for demographic parameters. The duration of onset of sensory and motor blocks was significantly shorter in the bupivacaine group ( P < 0.01). In the ropivacaine group, a faster recovery from sensory block ( P = 0.02) and higher segmental height [thoracic (T)10 and T8] were achieved ( P < 0.01). Bradycardia and hypotension were insignificant in the ropivacaine group ( P > 0.05). Isobaric ropivacaine is a better spinal anesthetic in lower abdominal surgeries as it provides faster recovery from sensory block and a higher level of segmental sensory block with fewer side-effects.

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“…1 Surgical procedure is completed in 60-90 min and it is associated with least intraoperative and postoperative complications. 2 Unless concurrent medical issues necessitate hospitalization for observation or specialist care, surgery can be performed as a day-care procedure. 3 Spinal anesthesia is the most common regional anesthesia technique used in lower abdominal surgeries such as inguinal hernia repair.…”

Section: Introductionmentioning

confidence: 99%

“…8 For day-care surgery, local anesthetic agent, which have rapid and smooth onset of action, intraoperative analgesia, good surgical condition, and short recovery period with least side effects, is preferred. 2 Although low dose of longer acting local anesthetic agents such as bupivacaine, ropivacaine, and levobupivacaine were administered intrathecally for day-care surgery, these were associated with longer hospital stay and less reliable for block efficacy, onset, and spread. 8 Furthermore, cardiotoxicity potential limits the use of bupivacaine as ideal drug for spinal anesthesia in day-care surgery.…”

Section: Introductionmentioning

confidence: 99%

“…8 Furthermore, cardiotoxicity potential limits the use of bupivacaine as ideal drug for spinal anesthesia in day-care surgery. 2 Later on, local anesthetic agents with shorter duration of action as the hyperbaric prilocaine 2% and the isobaric 1% 2-chloroprocaine (CP) were used in spinal anesthesia. These short-acting local anesthetic agents can be the perfect anesthetic drug for day-care surgery.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of anesthetic efficacy of intrathecal 1% isobaric 2-chloroprocaine with 0.5% isobaric ropivacaine for inguinal hernia surgeries

Suman Prabha Tirkey,

Suman Gupta,

Abhishek Gupta

et al. 2023

Asian J Med Sci

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Background: Inguinal hernia repair is one of the most common surgical conditions. In the absence of other comorbidities, it can be performed as a day-care procedure. Spinal anesthesia is most preferred technique this surgery. Local anesthetics having rapid and smooth onset of action, good intraoperative analgesia, short recovery period, and least side effects are preferred. Aims and Objectives: The objective of the study was to compare the anesthetic efficacy of intrathecal 1% isobaric 2-chloroprocaine (CP) and 0.5% isobaric ropivacaine for inguinal hernia surgeries. Materials and Methods: Sixty patients with ASA grade I/II scheduled for elective inguinal hernia surgeries were randomly allocated into group C (n=30), received 3 mL of 1% isobaric 2- CP and group R (n=30), received 3 mL of 0.5% isobaric ropivacaine intrathecally. Results: Demographic profile, mean time for onset of sensory blockade at T10, highest level of sensory blockade, and maximum motor blockade were comparable among the groups (P>0.05). The highest level of sensory blockade in group C is T7 and group R is T8. The mean time to two segment regression, complete sensory regression, complete motor recovery, recovery of parameters for achieving discharge criteria such as time to unassisted ambulation, drink water, micturition, and first rescue analgesia were significantly shorter in group C (P<0.0001). Visual analog scale score at the time of first rescue analgesia was significantly higher in group C (P<0.0001). Intraoperative hemodynamic changes and perioperative side effects were comparable (P>0.05). Conclusion: CP provides faster block resolution, earlier hospital discharge, and early ambulation with minimal side effects, making it a better alternative to ropivacaine for inguinal hernia surgeries.

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A prospective comparative observational study of clinical efficacy of isobaric ropivacaine 0.75% with of isobaric bupivacaine 0.5% intrathecally in elective inguinal hernia repair surgeries

Cited by 4 publications

References 9 publications

Saddle Block for Transrectal Prostate Biopsy: A Comparison of the Analgesic Efficacy of 0.25% Bupivacaine and 0.375% Ropivacaine

Saddle Block for Transrectal Prostate Biopsy: A Comparison of the Analgesic Efficacy of 0.25% Bupivacaine and 0.375% Ropivacaine

Isobaric forms of ropivacaine vs. bupivacaine in lower abdominal surgeries

Comparison of anesthetic efficacy of intrathecal 1% isobaric 2-chloroprocaine with 0.5% isobaric ropivacaine for inguinal hernia surgeries

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