A Prospective Comparative Study of the Toxicity Profile of 5-Flurouracil, Adriamycin, Cyclophosphamide Regime VS Adriamycin, Paclitaxel Regime in Patients with Locally Advanced Breast Carcinoma

Shajahan, Jihana; Pillai, Pradeep Sadasivan; Jayakumar, Krishnan Nair Lalithamma

doi:10.7860/jcdr/2015/15939.6864

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…Hematological toxicity is a common side effect of chemotherapy drugs such as anthracyclines, cyclophosphamide and taxane. 8 , 21 The chemotherapy drug 5-FU can also cause side effects such as anemia, leukopenia, and thrombocytopenia, 22 these being various expressions of myeloid toxicity. The rapid division rates of myeloid cells render them vulnerable targets of cytotoxic drugs.…”

Section: Discussionmentioning

confidence: 99%

The Relation of Haplotype ATP-binding Cassette B1 and Glutathione S-transferase P1 A313G Genes with Hematological Toxicity in Indonesian Breast Cancer Patients Receiving Chemotherapy

Syarifah¹,

Widyawati²,

Hasni³

et al. 2022

Oman Med J

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Objectives: Hematological toxicity induced by chemotherapy is known to be caused by multiple factors, including genetic factors, such as polymorphisms. The polymorphisms may occur in drug efflux transporter proteins and enzymes involved in drug metabolism. In our study, we investigate the incidence of hematological toxicities and its relation to the haplotype ATP-Binding Cassette B1 (ABCB1) which were polymorphism of C1236T, C3435T, G2677T and Glutathione S-Transferase P1 (GSTP1) A313G gene in Indonesian breast-cancer patients who receives anthracycline during chemotherapy. Methods: One hundred and thirty-eight breast-cancer patients in H. Adam Malik Hospital, Medan, Indonesia who were in the inclusion criteria were recruited in this retrospective cohort study. The DNA of patients was extracted from the peripheral leukocytes. Single nucleotide polymorphism (SNP) ABCB1 and GSTP1 were examined by the PCR-RFLP method. Data on patient characteristics and the incidence of hematological toxicity were obtained from patient medical records after three cycles of chemotherapy. Trend of absolute neutrophil count (ANC) and anemia were analyzed using the Friedmann test and the Wilcoxon signed-rank test. The Kruskal-Wallis test was performed to understand the association of ABCB1 and GSTP1 polymorphisms with the incidence of anemia and neutropenia. The frequency distribution of genotypes and alleles were determined using the Hardy-Weinberg Equilibrium (HWE). Results: A decrease of ANC was found after post chemotherapy on cycles 3 (Mean ± SD: 5644.48± 2962.545/mm3 vs 3034.89±2049.635/mm3 ), and the anemia (12.1478±1.50057 gr/dl vs 11.2746± 1.31221 gr/dl) after the patients underwent three chemotherapy cycles (p <0.05). There was no relation between ABCB1 polymorphism, either in each SNP or in the form of haplotype (the combination of more than one SNP) on the incidence of anemia and neutropenia (p> 0.05). In GSTP1 polymorphisms, no correlation between polymorphisms and anemia and neutropenia incidence (p> 0.05) was found. In our study, the ABCB1 and GSTP1 genotypes and alleles frequency distribution showed no deviation from HWE (p> 0.05). Conclusions: Patients who have performed the three cycles of hemotherapy demonstrated a susceptibility to the side effects of hematological toxicity (such as anemia and neutropenia); however, there was no relationship between ABCB1 and GSTP1 polymorphisms to hematological toxicity.

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Section: Discussionmentioning

confidence: 99%

The Relation of Haplotype ATP-binding Cassette B1 and Glutathione S-transferase P1 A313G Genes with Hematological Toxicity in Indonesian Breast Cancer Patients Receiving Chemotherapy

Syarifah¹,

Widyawati²,

Hasni³

et al. 2022

Oman Med J

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“…5-FU containing regimens are usually associated with hematological toxicity including anemia, leukopenia, and thrombocytopenia. Stomatitis and hyperpigmentation are other commonly reported toxicities (Shajahan et al, 2015).…”

Section: -Fluorouracil (5-fu)mentioning

confidence: 99%

Toxicity and Pharmacogenomic Biomarkers in Breast Cancer Chemotherapy

2020

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Breast cancer (BC) is one of the most prevalent types of cancer worldwide with high morbidity and mortality rates. Treatment modalities include systemic therapy, in which chemotherapy is a major component in many cases. Several chemotherapeutic agents are used in combinations or as single agents with many adverse events occurring in variable frequencies. These events can be a significant barrier in completing the treatment regimens. Germline genomic variants are thought of as potential determinants in chemotherapy response and the development of side effects. Some pharmacogenomic studies were designed to explore germline variants that can be used as biomarkers for predicting developing toxicity or adverse events during chemotherapy in BC. In this review, we reassess and summarize the major findings of pharmacogenomic studies of chemotherapy toxicity during BC management. In addition, deficiencies hampering utilizing these findings and the potential targets of future research are emphasized. Main insufficiencies in toxicity pharmacogenomics studies originate from study design, sample limitations, heterogeneity of selected genes, variants, and toxicity definitions. With the advent of high throughput genotyping techniques, researchers are expected to explore the identified as well as the potential genetic biomarkers of toxicity and efficacy to improve BC management. However, to achieve this, the limitations of previous work should be evaluated and avoided to reach more conclusive and translatable evidence for personalizing BC chemotherapy.

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Drugs that Act on the Immune System

Meaney

2015

Side Effects of Drugs Annual

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A Prospective Comparative Study of the Toxicity Profile of 5-Flurouracil, Adriamycin, Cyclophosphamide Regime VS Adriamycin, Paclitaxel Regime in Patients with Locally Advanced Breast Carcinoma

Cited by 4 publications

References 7 publications

The Relation of Haplotype ATP-binding Cassette B1 and Glutathione S-transferase P1 A313G Genes with Hematological Toxicity in Indonesian Breast Cancer Patients Receiving Chemotherapy

The Relation of Haplotype ATP-binding Cassette B1 and Glutathione S-transferase P1 A313G Genes with Hematological Toxicity in Indonesian Breast Cancer Patients Receiving Chemotherapy

Toxicity and Pharmacogenomic Biomarkers in Breast Cancer Chemotherapy

Drugs that Act on the Immune System

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