A Prospective Controlled Trial of Pulsed Nasal Nebulizer in Maximally Dissected Cadavers

Abstract

In all measured indices, the nasal douching method with the squeeze bottle was superior to the PARI sinus nebulizer in highly dissected sinonasal cadaver models.

Deposition of aerosols delivered by nasal route with jet and mesh nebulizers

“…Only 0.5 ± 0.3% of the nebulizer charge was deposited in the maxillary sinuses, corresponding to around 5% in terms of nasal deposition. These results are consistent with previous studies using a cadaver head (Valentine et al, 2008) or volunteers (Möller et al, 2009) measuring maxillary deposition in a similar range (3-5% in terms of nasal deposition). Similar low deposition results have been obtained in the ethmoid region corresponding to 1.1 ± 0.9% of the nebulizer charge and 11% of the nasal deposition.…”

“…Based on previous studies (Maniscalco, 2006;Möller et al, 2008Möller et al, , 2009Durand et al, 2001;Valentine et al, 2008), specific nasal jet nebulizers using sound effects are currently the best option for targeting antibiotic aerosols to the site of infection in case of chronic rhinosinusitis. This study demonstrates that aerosols produced by these specific nasal sonic jet nebulizers using sound effect are deposited in the anatomical targets to treat sinusitis.…”

“…The sound generates a positive pressure from the ostium to the maxillary sinuses allowing the gas exchange with the maxillary sinuses: it can be considered as a Helmholtz resonator (Maniscalco, 2006). In vitro and in vivo studies have demonstrated the benefit of applying this sound for maxillary sinus ventilation and deposition Möller et al, 2008;Durand et al, 2001;Valentine et al, 2008) increasing the aerosol deposition into maxillary sinuses by a factor two (Möller et al, 2009). Specific nasal sonic jet nebulizers using sound effect are therefore the best option for targeting antibiotic aerosols to the site of infection in the case of chronic rhinosinusitis.…”

Irrigation penetration of nasal delivery systems: A cadaver study

“…5,6 There is an everincreasing array of products available for nasal irrigation, and only limited direct comparisons have been performed. [5][6][7][8] The aim of this study was to compare the efficacy of 7 commercially available and popular devices on maximally operated cadaveric sinuses under direct visualization.…”

Advances in the Surgical Management of Chronic Sinusitis and Nasal Polyps

“…It has been shown that endoscopic sinus surgery improves distribution into the sinuses, with a minimal ostial size of 4 mm needed to begin seeing sinus penetration [14]. Largevolume squeeze bottles or passive flow devices such as the Neti Pot (Himalayan Institute, Honesdale, PA) appear to have the best sinus penetration after endoscopic sinus surgery, with higher volume and pressure likely resulting in the best distribution [15]. It has been estimated that 5% to 37% of topically deposited medications are absorbed by the mucosa, with the rest being removed by mucociliary transport [16].…”