A prospective epidemiological study on odontogenic tumours in a black African population, with emphasis on the relative frequency of ameloblastoma

Oginni, Fadekemi Olufunmilayo; Stoelinga, Paul J.W.; Ajike, SO; Obuekwe, ON; Olokun, B. Aluko; Adebola, RA; Adeyemo, WL; Fasola, O.; Adesina, O A; Akinbami, Babatunde O.; Iwegbu, I.O.; Ogunmuyiwa, S.A.; Obimakinde, Obitade Sunday; Uguru, Chibuzo

doi:10.1016/j.ijom.2015.03.018

Cited by 40 publications

(39 citation statements)

References 21 publications

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“…The data are in agreement with the rate of studies that showed a relative frequency of OM in Asia, Europe, and America varying between 0.5% and 17.7% . In addition, the studies analyzed in the present review demonstrated a relative incidence of OM of 4.5% in Africa, 8.8% in America, and 10.64% in Asia, demonstrating a geographic variation in the prevalence of OM. The comparison of the real prevalence of this lesion in different regions may be difficult mainly because of the different periods of analysis in each population and the relative lack of epidemiological studies about OM .…”

Section: Discussionsupporting

confidence: 91%

Odontogenic myxoma: A 63‐year retrospective multicenter study of 85 cases in a Brazil population and a review of 999 cases from literature

Vasconcelos

Silveira

Gomes

et al. 2017

J Oral Pathology Medicine

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Background Odontogenic myxoma (OM) is an uncommon neoplasm of the jaws. Considering the importance of defining the relative incidence and demographic profile of these lesions in South America, the aim of this study was to analyze the clinical and imagiological features of OM from three South American oral pathology services and to discuss these findings in light of the literature. Methods Data regarding age, gender, anatomic site, and imagiological features from 85 cases of OM were collected. Additionally, we did a review of OM studies published in three electronic databases. Results Among 63 450 oral biopsies, 1178 (1.85%) were odontogenic tumors (World Health Organization ‐ 2017), of which 85 (7.21%) met the criteria of OM. The mean age was 30.7 years (range: 10‐61 years; SD: 12.22). Forty‐five (52.9%) cases occurred in females and 40 (47.1%) in males (ratio: 1:1.12). Maxilla was affected in 44 cases (53%) and mandible in 39 (47%). Of the 41 informed cases (48.2%), all of them were radiolucent lesions. The literature review indicated a majority of mean ages in third decade and a predilection for females, mandible, and multilocular radiolucent lesions. Conclusions The features of OM samples have strong similarity to that reported in studies from other continents. It is possible to infer that geographic variation does not help to explain some differences observed in the clinical features of OM.

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Section: Discussionsupporting

confidence: 91%

Odontogenic myxoma: A 63‐year retrospective multicenter study of 85 cases in a Brazil population and a review of 999 cases from literature

Vasconcelos

Silveira

Gomes

et al. 2017

J Oral Pathology Medicine

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“…For 19.77% of the included studies, no clear indication on the used imaging modality was presented 8,9,13,16,17,22,25,30,34,37,42,53,57 . Additionally, some studies did not report any imaging modalities 15,18,20,24,26,29,31‐33,35,38‐41,43‐45,47,49,50,52‐54,58‐60 …”

Section: Resultsmentioning

confidence: 99%

“…8,9,13,16,17,22,25,30,34,37,42,53,57 Additionally, some studies did not report any imaging modalities. 15,18,20,24,26,29,[31][32][33]35,[38][39][40][41][43][44][45]47,49,50,[52][53][54][58][59][60] Commonly, radiographic appearance was multilocular aspect (57.49%), followed by unilocular aspect (32.87%), and mixed aspect (9.64%). The main site of involvement was a posterior mandible (59.48%) followed by the anterior region (16.23%).…”

Section: Synthesis Of Resultsmentioning

confidence: 99%

Odontogenic Myxoma: Systematic review and bias analysis

Dotta

Miotto

Spin‐Neto

et al. 2020

Eur J Clin Investigation

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Background Odontogenic myxoma (OM) is a rare neoplasm, which originates from odontogenic ectomesenchyme. There is no study in the literature that analyses the best standards for OM diagnosis and how the treatment modalities may influence the recurrence rates. Objective To evaluate the best standards for odontogenic myxoma (OM) diagnosis and treatment, and how these may influence the recurrence rates. Study design Two independent researchers performed a systematic review in many databases. Fifty‐two eligible studies were included for qualitative analysis. Bias analysis was conducted according to Oxford Centre for Evidence‐Based Medicine. Results A total of 1363 OM cases were reported on, and female gender with average age of 27 years is the most common patient profile. Conventional microscopic findings were observed in 93.43% of the reported cases. In 57.49% of the cases, multilocular radiographic appearance was present, followed by unilocular appearance (32.87%). Posterior mandible was the site with the major prevalence, while surgical resection was the most common treatment modality, followed by enucleation. Recurrence rates for both treatment modalities were approximately close (13.04% and 25.0%, respectively). Conclusion The correct diagnosis of OM relies on the association of clinical, radiographic and microscopic findings. About imaging examinations, panoramic radiography and computed tomography are sufficient for the evaluation of OM. Recurrence rates were closely among the two most used surgery treatments. So according to some clinical‐radiological aspects, conservative surgery may be preferred than aggressive surgery modalities.

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“…Ameloblastoma constitutes about 14% of all jaw tumors and cysts, and it is the most prevalent odontogenic tumors in developing countries (Lasisi et al , ; Oginni et al , ). The global incidence of ameloblastoma is 0.5 cases per million persons per year (Brown and Betz, ), and it is a highly encountered odontogenic tumor in Africa and China (Bassey et al , ).…”

Section: Introductionmentioning

confidence: 99%

Ameloblastoma: current etiopathological concepts and management

et al. 2017

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Ameloblastoma is a benign odontogenic tumor of epithelial origin. It is locally aggressive with unlimited growth capacity and has a high potential for malignant transformation as well as metastasis. Ameloblastoma has no established preventive measures although majority of patients are between ages 30 and 60 years. Molecular and genetic factors that promote oncogenic transformation of odontogenic epithelium to ameloblastoma are strongly linked to dysregulation of multiple genes associated with mitogen-activated protein kinase, sonic hedgehog, and WNT/b-catenin signaling pathways. Treatment of ameloblastoma is focused on surgical resection with a wide margin of normal tissue because of its high propensity for locoregional invasion; but this is often associated with significant patient morbidity. The relatively high recurrence rate of ameloblastoma is influenced by the type of molecular etiological factors, the management approach, and how early the patient presents for treatment. It is expected that further elucidation of molecular factors that orchestrate pathogenesis and recurrence of ameloblastoma will lead to new diagnostic markers and targeted drug therapies for ameloblastoma. Oral Diseases (2018) 24, 307-316

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A prospective epidemiological study on odontogenic tumours in a black African population, with emphasis on the relative frequency of ameloblastoma

Cited by 40 publications

References 21 publications

Odontogenic myxoma: A 63‐year retrospective multicenter study of 85 cases in a Brazil population and a review of 999 cases from literature

Odontogenic myxoma: A 63‐year retrospective multicenter study of 85 cases in a Brazil population and a review of 999 cases from literature

Odontogenic Myxoma: Systematic review and bias analysis

Ameloblastoma: current etiopathological concepts and management

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