Purpose To compare results of two surgical techniques; anteriorization (ATIO) vs anterior nasalization (ANT) of IO muscle in management of DVD associated with IOOA. Methods Twenty-one patients with DVD associated with IOOA were included in this study. Group A consists of 11 patients who underwent ATIO and group B with 10 patients who underwent anterior transposition of IO to the nasal border of inferior rectus ANT. All patients were followed for at least 6 months postoperatively. The primary outcome variables were changes in DVD in primary position and side gazes, IO action and V pattern. Results The average of correction of DVD in primary position, in adduction and in abduction was 10.63 PD, 24.6 PD (Po0.001) and 0.45 PD5 (P40.05) in ATIO group and 14.6 PD, 25.2 PD and 1.7 PD (Po0.001) in ANT group respectively. Mean IOOA decreased from +2.0 ± 0.7 to +0.18 ± 0.4 in group A (Po0.001) and from +2.5 ± 0.7 to +0.1 ± 0.5 (Po0.001) in group B. Mean V pattern was corrected from 19.18 ± 7.1 PD to 11.18 ± 4.9 PD (Po0.01) in group A and from 17.8 ± 7.9 PD to 6.0 ± 2.49 PD (Po0.001) in group B. In group B, two patients developed hypotropia of 2 and 4 PD and one patient developed consecutive exotropia. Conclusions In DVD associated with IOOA, both surgical techniques are almost similar in alleviating true hypertropia in side gaze, IOOA, and V pattern. ANT gives more statistically significant DVD correction in primary position and in abduction while in adduction; there is no significant difference between both groups. However, ANT may induce hypotropia and consecutive horizontal strabismus.