A Prospective Evaluation of Tru-Cut Biopsy and Fine-needle Aspiration Cytology in Male Breast Cancer Detection

Abstract

Background: Male breast-cancer (MBC) is often diagnosed late. Our purpose was to evaluate fine-needle aspiration cytology (FNAC) versus Tru-Cut biopsy (TCNB) in MBC diagnosis. Patients and Methods: Men with suspicious breast lesions were prospectively enrolled; 54 met the inclusion criteria and underwent FNAC and TCNB. FNAC, TCNB and gold-standard results were compared. Results: Unsatisfactory results were 11.1% after FNAC and none after TCNB (p=0.027). After gold-standard evaluation, the diagnosis of FNAC and TCNB was confirmed, respectively, in 63.0% and 98.1% and changed in 37.0% and 1.9% (p<0.001). The malignancy rate after FNAC, TCNB and surgery were, respectively, 25.9%, 33.3% and 35.1% (FNAC vs. TCNB p=0.5276, FNAC vs. surgery p=0.404; TCNB vs. surgery p=1). Among invasive carcinomas, 93.8% were identified by FNAC vs. 87.5% by TCNB (p=1); all ductal carcinoma in situ (DCIS) were detected after TCNB and none after FNAC (p=0.1). Conclusion: FNAC leads to a significantly higher number of inadequate samplings and seems to be subject to increased DCIS misdiagnoses. TCNB correlated better to the final histological report.

Value of dynamic contrast-enhanced magnetic resonance imaging in combination with mammography for screening early-stage breast cancer

“…Therefore, early screening and treatment are of great significance for reducing the mortality rate of patients with breast cancer. At present, biopsy is the “gold standard” for the clinical diagnosis of breast cancer, which, however, is invasive and cumbersome in clinical application 3 .…”

“…Therefore, early screening and treatment are of great significance for reducing the mortality rate of patients with breast cancer. At present, biopsy is the "gold standard" for the clinical diagnosis of breast cancer, which, however, is invasive and cumbersome in clinical application 3 . Recently, mammography, ultrasonography (US), and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) have been applied in the diagnosis of breast cancer in clinical practice.…”