2021
DOI: 10.1002/jmri.27605
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A Prospective, Longitudinal Magnetic Resonance Imaging Evaluation of Cerebrovascular Reactivity and Infarct Development in Patients With Intracranial Stenosis

Abstract: Background Patients with symptomatic atherosclerotic and non‐atherosclerotic (i.e., moyamoya) intracranial steno‐occlusive disease experience high 2‐year infarct rates. Purpose To investigate whether cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) measures may provide biomarkers of 1‐to‐2‐year infarct risk. Study Type Prospective, longitudinal study. Subjects Adult participants (age = 18–85 years) with symptomatic intracranial atherosclerotic disease (N = 26) or non‐atherosclerotic (i.e., moyamo… Show more

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Cited by 10 publications
(7 citation statements)
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“…Figure 4 summarizes group results in participants who did not receive prior revascularization procedures, which reflect the primary study hypothesis. For the cortical region (Figure 4A), significant changes were observed on ANOVA across stenosis categories for CVR RAW ( p = .003), CVR MAX ( p = .01), and CVR DELAY ( p = .008), which is consistent with the fact that increasing levels of MCA or ICA steno‐occlusion reduce cerebrovascular reactivity and increase cerebrovascular delay times in the arterial territory of the affected vessel 20,21 . Figure 4A along with Table 2 shows that in nonsurgical participants, the cortical CVR RAW and CVR MAX decrease and CVR DELAY increases with increasing steno‐occlusion.…”
Section: Resultssupporting
confidence: 74%
“…Figure 4 summarizes group results in participants who did not receive prior revascularization procedures, which reflect the primary study hypothesis. For the cortical region (Figure 4A), significant changes were observed on ANOVA across stenosis categories for CVR RAW ( p = .003), CVR MAX ( p = .01), and CVR DELAY ( p = .008), which is consistent with the fact that increasing levels of MCA or ICA steno‐occlusion reduce cerebrovascular reactivity and increase cerebrovascular delay times in the arterial territory of the affected vessel 20,21 . Figure 4A along with Table 2 shows that in nonsurgical participants, the cortical CVR RAW and CVR MAX decrease and CVR DELAY increases with increasing steno‐occlusion.…”
Section: Resultssupporting
confidence: 74%
“…2 Cerebrovascular reserve capacity and collateral circulation may be more specific indicators of vascular health and may portend collateral pathway formation in patients with moyamoya, and as such cerebrovascular reactivity (CVR) measures are being adopted with increasing frequency. 6,7 CVR may be evaluated by challenging vessels using a hypercapnic vasodilatory stimulus; in compliant vasculature, this leads to arteriolar smooth muscle relaxation and subsequential increase in cerebral blood volume (CBV) and CBF. The magnitude and timing of the CBV and CBF changes provide a marker of the hemodynamic reserve capacity or the potential ability of parenchyma to compensate for changes in perfusion pressure.…”
mentioning
confidence: 99%
“…S troke is the second leading cause of mortality and disability worldwide. 1 In both acute [2][3][4] and chronic [5][6][7][8][9] cerebrovascular disorders, perfusion imaging helps in identifying the salvageable, hypoperfused tissue at risk for evaluating future strokes, as well as in selecting patients eligible for revascularization or reperfusion therapies. Traditionally, clinical perfusion imaging has entailed the use of exogenous contrast materials such as iodine or xenon for CT and gadolinium for MRI or radioactive tracers for positron emission tomography (PET) and single-photon emission computed tomography (SPECT) 10 .…”
mentioning
confidence: 99%