A Prospective Longitudinal Study of Platelet Angiotensin II Receptors for the Prediction of Preeclampsia

Massé, Jacques; Forest, Jean‐Claude; Moutquin, Jean‐Marie; DeGrandpré, Pierre; Forest, Véronique Isabelle

doi:10.1016/s0009-9120(98)00021-6

Cited by 15 publications

(6 citation statements)

References 21 publications

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“…38 This process has been used since 1987 in the perinatal research unit in the course of other cohort studies, and no significant discrepancy occurred when compared with clinical assessment by 2 clinicians. 45,46 Third, our study was conducted in nulliparous women, a clinically more homogenous population of cases of preeclampsia. Fourth, matching of cases and control subjects for several known risk factors of preeclampsia and/or essential hypertension minimized the influence of confounding factors.…”

Section: Discussionmentioning

confidence: 99%

Implication of an AGT Haplotype in a Multigene Association Study With Pregnancy Hypertension

et al. 2004

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Abstract-Several association studies of candidate genes for preeclampsia and essential hypertension have led to discordant results, partly because of small sample sizes. Using a large population-based sample of pregnant women, we conducted an association study of 10 polymorphisms in 9 genes and aimed (1) to validate 10 published associations with preeclampsia or essential hypertension, (2) to investigate candidate polymorphisms previously associated with preeclampsia for association with essential hypertension and similarly with polymorphisms previously associated with essential hypertension. From a prospective sample of 3391 nulliparous French Canadian pregnant women, we identified 180 cases of preeclampsia, 203 cases of essential hypertension that were matched with normotensive control subjects (nϭ310 and 357, respectively). Polymorphisms were genotyped by allele-specific PCR. Among our candidate polymorphisms, the Met allele of Thr174Met of AGT was associated with preeclampsia (Pϭ0.0033). Haplotype analysis revealed that the A-Met-Thr (G1035A-Thr174Met-Met235Thr) haplotype was associated with a 2.1-fold increased risk of preeclampsia (95% CI, 1.4 to 3.4; Pϭ0.0008). In conclusion, we observed a strong association between a specific AGT haplotype and preeclampsia in our population, without replicating previous published associations with either preeclampsia or essential hypertension. Our data support a role for AGT in genetic susceptibility to preeclampsia.

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Section: Discussionmentioning

confidence: 99%

Implication of an AGT Haplotype in a Multigene Association Study With Pregnancy Hypertension

et al. 2004

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“…16,17 For these studies, Ͼ4000 pregnant women were recruited between the 11th and the 27th week of gestation. Multiparous women and women with known renal diseases, diabetes mellitus, or CVD were excluded from these studies.…”

Section: Study Populationmentioning

confidence: 99%

Previous Hypertensive Disease of Pregnancy Is Associated With Alterations of Markers of Insulin Resistance

et al. 2007

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Abstract-Insulin resistance syndrome has been observed in women with hypertensive disease of pregnancy, but few studies evaluated the presence of the syndrome a few years after delivery. The objective of this study was to evaluate the presence of insulin resistance and its metabolic alterations in these women compared with those who had a normal pregnancy. We performed an observational study in 168 women with previous hypertensive disease of pregnancy and 168 control subjects with normal pregnancy contacted, on average, 7.8 years after their first delivery (mean age: 34.8 years). Complete blood lipid profile, insulin, glucose, homocysteine, adipokins, and markers of inflammation were measured. Also, an oral glucose tolerance test was performed in 146 case and 135 control subjects. Case subjects were more overweight compared with control subjects. We found significantly lower high-density lipoprotein cholesterol and adiponectin levels and higher apolipoprotein (apo) apoB/apoA1 ratio, homocysteine, leptin, and insulin levels among case subjects compared with control subjects (PՅ0.004). Also, case subjects were more insulin resistant in the basal state estimated by homeostasis assessment model 2, as well as in the nonbasal state as estimated by insulin sensitivity indices calculated from the oral glucose tolerance test. Finally, in a multivariate regression model, leptin, apoB/apoA1 ratio, waist circumference, adiponectin, and free fatty acids explained 40% of homeostasis assessment model 2 variance. Young women with previous hypertensive disease of pregnancy show signs of insulin resistance within the first decade after delivery. These findings suggest that insulin resistance may be the link between hypertensive disease of pregnancy and increased cardiovascular risk later in life. Key Words: hypertension Ⅲ insulin resistance Ⅲ obesity Ⅲ preeclampsia Ⅲ gestational hypertension Ⅲ cardiovascular diseases Ⅲ dyslipidemia H ypertensive disease of pregnancy (HDP) appears after the 20th week of gestation in women and is classified into 2 main groups: the nonproteinuric group, including gestational hypertension (GH) and transient hypertension, and the preeclampsia (PE) group characterized by proteinuria, returning to normal values in the postpartum period. All together, they occur in Ϸ8% of pregnancies. 1 Epidemiological data suggest that women with previous HDP are at increased risk of cardiovascular disease (CVD) later in life. [2][3][4] Also, review articles proposed that insulin resistance could play a role bridging HDP to long-term CVD, but data are lacking to validate the hypothesis. 5,6 During normal pregnancy, insulin resistance progresses until the third trimester to facilitate the transfer of glucose to the fetus, and insulin returns to a normal level after delivery. However, in women suffering from HDP, recent data indicate that insulin resistance and the associated metabolic disturbances, such as dyslipidemia and hyperinsulinemia, are more pronounced compared with pregnant women without this complication. 7,8 A...

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“…They were recruited from a cohort of women studied during pregnancy to identify biological and echographic markers of HDP in nulliparous women (Irion et al 1998;Masse et al 1993Masse et al , 1998. Most subjects were Caucasians (98%, by self assessment of origin) from the Quebec City metropolitan area where 93% of the population is of French ancestry (Santé Qué bec 1995).…”

Section: Study Subjectsmentioning

confidence: 99%

The combination of ApoCIII, hepatic lipase and hormono sensitive lipase gene polymorphisms suggests an association with susceptibility to gestational hypertension

et al. 2007

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Dyslipidemia and insulin resistance contribute to the endothelial cell dysfunction in hypertensive disorders of pregnancy (HDP) and increase the long-term risk of cardiovascular disease (CVD). The genes linking susceptibility to gestational hypertension (GH) and/or preeclampsia (PE) to the long-term risk of CVD are still unknown. We evaluated the potential association between 14 polymorphisms from six genes involved in lipid metabolism and insulin action and the risk of HDP: namely the lipoprotein lipase (LPL), hepatic lipase (LIPC), hormone sensitive lipase (LIPE), cholesteryl ester transfer protein (CETP), ApoCIII and ApoE gene polymorphisms. Overall, 169 women with HDP [proteinuria (PE) and gestational hypertension without proteinuria (GH)] and 169 controls matched for age and year of delivery were genotyped. Homozygosity of the -514T allele of the -514C > T polymorphism (LIPC gene) decreased the risk of GH (OR = 0.17, CI 95 : 0.02-0.76), while there were more -60G carriers of the -60C > G LIPE gene polymorphism (OR = 3.51, CI 95 :1.02-12.10) among GH cases, but not in PE cases. The common ApoCIII two-locus -482CC/3238CC genotype was lower in women with GH compared with controls (OR = 0.53, CI 95 : 0.3-0.9). The combined frequency of at-risk genotypes was higher in cases of GH compared with controls [one at-risk genotype: OR = 3.38 (95% CI: 0.48-41.8); two or more at-risk genotypes: OR = 7.14 (95% CI: 1.21-92.3, P = 0.01)], suggesting a gene-dose effect. We conclude that the combined effect of LIPC, LIPE and ApoCIII gene polymorphisms may increase the likelihood of GH, but seemingly not of PE.

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A Prospective Longitudinal Study of Platelet Angiotensin II Receptors for the Prediction of Preeclampsia

Cited by 15 publications

References 21 publications

Implication of an AGT Haplotype in a Multigene Association Study With Pregnancy Hypertension

Implication of an AGT Haplotype in a Multigene Association Study With Pregnancy Hypertension

Previous Hypertensive Disease of Pregnancy Is Associated With Alterations of Markers of Insulin Resistance

The combination of ApoCIII, hepatic lipase and hormono sensitive lipase gene polymorphisms suggests an association with susceptibility to gestational hypertension

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