A prospective, longitudinal study of the long-term effect of treatment on bone density in children with celiac disease

Mora, Stefano; Barera, Graziano; Beccio, Sabrina; Menni, Laura; Proverbio, Maria Carla; Bianchi, Cesare; Chiumello, G

doi:10.1067/mpd.2001.116298

Cited by 125 publications

(87 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Accordingly, BMD is restored more quickly in patients with subclinical than with classical symptomatic disease: 1 year of gluten restriction normalized LS BMD in adults with subclinical disease but had little effect in patients with severe symptomatic disease (16). Likewise, BMD increased significantly after 1-4.3 years of gluten restriction in heterogeneous groups of children with symptomatic as well as subclinical celiac disease (20,23). Thus, osteopenia in patients with subclinical disease can be reversed if detected at an early stage.…”

Section: The Case For Screening-michael Freemarkmentioning

confidence: 96%

“…Several studies demonstrate that bone mineral density and bone mineral content is diminished before treatment and improved after adherence to diet in symptomatic children (23,69). Fracture risk and risk of severe osteopenia are increased in noncompliant or newly diagnosed adults with longstanding celiac disease.…”

Section: Bone Developmentmentioning

confidence: 99%

“…Symptomatic undiagnosed individuals can develop profound growth attenuation, failure of pubertal maturation, gastrointestinal illness (3,52), neurologic dysfunction (32), non-Hodgkin's lymphoma (44), osteopenia (23), infertility in females (62), and anemia (51). In addition, it has been suggested that unexpected hy-…”

Section: Diagnostic Criteria For Celiac Disease May Varymentioning

confidence: 99%

See 2 more Smart Citations

Screening for Celiac Disease in Children With Type 1 Diabetes

2003

View full text Add to dashboard Cite

Section: The Case For Screening-michael Freemarkmentioning

confidence: 96%

Section: Bone Developmentmentioning

confidence: 99%

Section: Diagnostic Criteria For Celiac Disease May Varymentioning

confidence: 99%

See 1 more Smart Citation

Screening for Celiac Disease in Children With Type 1 Diabetes

2003

View full text Add to dashboard Cite

“…It can be prevented by adherence to a glutenfree diet and is reversed in children and young adults within one year of diagnosis through dietary compliance (49)(50)(51). Whether asymptomatic individuals detected by screening will have the same incidence of osteopenia and osteoporosis is not yet established.…”

Section: Osteoporosismentioning

confidence: 99%

Practical considerations for the identification and follow-up of children with celiac disease

Dirks

2004

Paediatrics &Amp; Child Health

View full text Add to dashboard Cite

Celiac disease is an immune-mediated enteropathy affecting 0.5% to 1% of children and is induced by dietary gluten in susceptible individuals carrying the human leukocyte antigen DQ2 or DQ8 heterodimer. If serological screening is positive or if a patient displays suggestive symptoms, an endoscopic biopsy of the distal duodenum is required to confirm the diagnosis. Symptoms of celiac disease are often mild or absent. Overt malabsorption occurs in only 2% to 10% of children. Individuals with a higher risk of developing celiac disease, including first-degree relatives of affected patients and children with type I diabetes, Turner syndrome, Williams syndrome or Down syndrome, should be offered screening for celiac disease along with a discussion of the implications. If serological testing is negative, a high index of suspicion should remain if malabsorption, iron deficiency or osteopenia is present. Also, immunoglobulin A deficiency should be excluded. At-risk individuals should undergo serial serological screening. Lifelong adherence to a gluten-free diet is the only treatment. If left untreated, symptomatic children with celiac disease carry an increased risk of developing osteoporosis and have a greater lifetime risk of cancer. The long-term outcome of undiagnosed or untreated asymptomatic individuals is less clear.Key Words: Celiac disease; Gluten-free diet; Gluten-sensitive enteropathy; IgA deficiency; Tissue transglutaminase; Type I diabetes Des considérations pratiques pour dépister et suivre les enfants atteints d'une maladie coeliaqueLa maladie coeliaque est une entéropathie d'origine immunologique qui touche de 0,5 % à 1,0 % des enfants et qui est induite par le gluten diététique chez des individus susceptibles porteurs de l'antigène HLA DQ2 ou DQ8 hétérodimère. Si le dépistage sérologique est positif ou si un patient présente des symptômes évocateurs, une biopsie endoscopique du duodénum distal s'impose pour confirmer le diagnostic. Les symptômes de maladie coeliaque sont souvent légers ou inexistants. Une malabsorption patente ne s'observe que chez 2 % à 10 % des enfants. Les individus plus vulnérables à la maladie coeliaque, y compris les parents au premier degré des patients atteints et les enfants souffrant

show abstract

“…Os adultos com DC apresentam risco aumentado para DMO reduzida [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] . Por outro lado, são poucos os dados acerca da DMO em crianças e adolescentes com DC [21][22][23][24][25][26][27][28][29] .…”

unclassified

Celiac disease under treatment: evaluation of bone mineral density

Carvalho¹,

Sdepanian²,

Neto³

et al. 2003

J Pediatr (Rio J)

View full text Add to dashboard Cite

Objective: the present study was designed to compare the bone mineral density of children and adolescents with celiac disease to the bone mineral density of controls, and to evaluate laboratory analysis of calcium metabolism of celiac disease patients.Methods: thirty celiac disease patients (17 children, 13 adolescents), on a gluten-free diet, and 23 healthy subjects were studied. Tests of bone mineral density of the lumbar spine (DEXA, Lunar) were performed in all patients and controls. Laboratory analysis of calcium metabolism was performed in all patients.Results: mean weight and height of adolescents with celiac disease were lower than mean weight and height of controls (p<0.05). Bone mineral density in adolescents with celiac disease was significantly reduced if compared to controls (p=0.015), whereas no significant difference was found among children with celiac disease and controls. The number of adolescents who had started a glutenfree diet after the age of 2 years was higher than in children (p=0.003). Serum levels of ionized calcium, total calcium and parathormone were normal.Conclusions: the one mineral density of adolescents with celiac disease was lower than controls; whereas, no difference was found between the bone mineral density of children with celiac disease and controls.J Pediatr (Rio J) 2003;79(4):303-8: celiac disease, diet therapy, bone density, child, adolescent. ResumoObjetivo: comparar a densidade mineral óssea de crianças e adolescentes com doença celíaca em tratamento com controles sadios, e avaliar exames laboratoriais relacionados com o metabolismo do cálcio.Métodos: foram estudados 30 pacientes com doença celíaca em dieta isenta de glúten, 17 crianças e 13 adolescentes, e 23 indivíduos saudáveis. Todos os pacientes e controles realizaram a densidade mineral óssea (DEXA, Lunar). Os pacientes realizaram dosagem sérica de cálcio total, cálcio ionizado, fósforo, magnésio, fosfatase alcalina e paratormônio.Resultados: a média de peso, estatura e densidade mineral óssea dos adolescentes com doença celíaca foi menor do que dos controles (p<0,05), enquanto que não se observaram diferenças estatisticamente significantes destes parâmetros, comparando as crianças com doença celíaca com os controles. A proporção de adolescentes que iniciou dieta isenta de glúten após os dois anos de idade foi maior do que a de crianças (p<0,05). Os pacientes apresentaram níveis séricos normais de cálcio ionizado, cálcio total e paratormônio.Conclusões: a densidade mineral óssea dos adolescentes com doença celíaca em dieta isenta de glúten foi menor do que dos controles. Por outro lado, não houve diferença entre a densidade mineral óssea de crianças com doença celíaca e controles.J Pediatr (Rio J) 2003;79(4):303-8: doença celíaca, dietoterapia, densidade óssea, criança, adolescente.

show abstract

A prospective, longitudinal study of the long-term effect of treatment on bone density in children with celiac disease

Cited by 125 publications

References 20 publications

Screening for Celiac Disease in Children With Type 1 Diabetes

Screening for Celiac Disease in Children With Type 1 Diabetes

Practical considerations for the identification and follow-up of children with celiac disease

Celiac disease under treatment: evaluation of bone mineral density

Contact Info

Product

Resources

About