A prospective observational study assessing the outcome of Sepsis in intensive care unit of a tertiary care hospital, Peshawar

Abstract

Objective:The current study aims to explore the factors associated with outcome among patients with severe sepsis and septic shock admitted to the intensive care unit, Northwest General Hospital and Research Centre, Peshawar, Pakistan.Methods:A prospective observational study was carried out at intensive care unit of our hospital from February 2014 to October 2015. Data was collected using a structured format and statistical analysis was done using SPSS version 20®. Regression model was applied to identify the factors contributing to the outcome of severe sepsis and septic shock. P-value less than 0.05 was considered statistically significant.Results:Majority of the patients meeting the criteria of this study were male 147 (54.9%) with a mean age of 54.8. The most common source of sepsis was lung infections (42.2%) followed by urinary tract infections (18.7%), soft tissue infections (6.3%) abdominal infections (6%) and in 6.3% patients the source remained unknown. Further analysis has revealed that increase in number of days of hospitalization was observed to be slightly associated with the outcome of the treatment (1.086 [1.002 – 1.178], 0.046). Moreover, the risk of mortality was the higher among the patients with septic shock 22.161[10.055 – 48.840], and having respiratory, kidney and central nervous system complications. Overall it is seen that septic shock alone was found responsible to cause death among 32.0% of the patients (Model 1: R2 0.32, p=0.000), and upon involvement of the organ complications the risk of mortality was observed to 42.0%.Conclusion:Chances of recovery were poor among the patients with septic shock. Moreover, those patients having respiratory and urinary tract infection are least likely to survive.

Comparison of qSOFA and SOFA score for predicting mortality in severe sepsis and septic shock patients in the emergency department of a low middle income country

“…Our study evaluated and compared performance of the qSOFA score and SOFA in septic ED patients from a low to middle income country with a high reported severity of illness and mortality than quoted locally 3 , 22 as well as those from high income nations. 17 …”

Evaluation of Antibiotic Use Among Sepsis Patients in an Intensive Care Unit: A cross-sectional study at a referral hospital in Indonesia

“…occurs in approximately 2% of all hospitalised cases and among 6-30% of all patients admitted to intensive care units (ICUs) in developed countries. 3,4 Both sepsis and septic shock are leading causes of morbidity and mortality in ICUs (21% and 28%, respectively). [4][5][6] The management of sepsis or septic shock requires a comprehensive and systematic approach combining the use of appropriate diagnostic measures, the rapid initiation of appropriate empirical antibiotics and the administration of supportive therapy.…”

Factors associated with outcomes of septic shock patients receiving high dose noradrenaline according to three primary infection sites

“…For example, although mortality rates of 6-11% have been recorded following abdominal infection, 19,20 after the infection has progressed to septic shock, the risk of death increases dramatically. 21 One study found that the 7-day mortality of patients with pyelonephritis and septic shock was 26% while those without septic shock was zero. 22 Our study showed that high SOFA scores on Day 1 were associated with increased risk of death.…”