A Prospective Observational Study of 42 Patients with COVID-19 infection and a History of Hepatitis C Virus Infection and Thyroid Disease with Follow-Up Thyroid Function and Autoantibody Testing

Badiu, Dumitru Cristinel; Popescu, Gabriel Cristian; Zgură, Anca; Stanciu, Adriana Mercan; Dodot, Mihai; Mehedințu, Claudia; Toma, Letiția; Simu, Razvan; Bacinschi, Xenia; Hăineală, B.

doi:10.12659/msm.935075

Cited by 5 publications

(5 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While patients with autoimmune thyroiditis had a significant increase in anti-thyroid peroxidase antibodies (ATPO) and anti-thyroglobulin antibodies (anti-Tg) levels at a 1-month follow-up after contracting the respiratory infection, patients with euthyroidism had a significant decrease in thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4) levels. As such, it was concluded that thyroid involvement and its markers should not be overlooked [ 117 ].…”

Section: Resultsmentioning

confidence: 99%

COVID-19 and Laboratory Markers from Romanian Patients—A Narrative Review

Musat,

Sorop,

Sorop

et al. 2023

Life

View full text Add to dashboard Cite

COVID-19 has significantly impacted the whole world, and Romania was no exception. Biomarkers play a crucial role in understanding and managing the disease. However, research regarding laboratory analyses for patients with COVID-19 is fairly limited. For detection, PCR testing is still considered the golden standard, while antibodies are still useful for monitoring both patients and their vaccination status. In our country, biomarkers such as CRP, LDH, transaminases, cardiac, and iron markers have been used to assess the status of patients and even predict illness outcome. CRP, IL-6, LDH, FER, fibrinogen, creatinine, and vitamin D levels have been associated with increased severity, risk of ICU admission, and death. Cardiac markers and D-dimers are also good predictors, but their role seems more important in patients with complications. HDL cholesterol and BUN levels were also suggested as potential biomarkers. Hematological issues in SARS-CoV-2 infections include neutrophilia, lymphopenia and their ratio, while PCT, which is a marker of bacterial infections, is better to be used in patients with co- or supra-infections. The current research is a narrative review that focuses on the laboratory results of Romanian COVID-19 patients. The goal of this article is to provide an update on the research on biomarkers and other laboratory tests conducted inside the borders of Romania and identify gaps in this regard. Secondly, options for further research are discussed and encouraged.

show abstract

Section: Resultsmentioning

confidence: 99%

COVID-19 and Laboratory Markers from Romanian Patients—A Narrative Review

Musat,

Sorop,

Sorop

et al. 2023

Life

View full text Add to dashboard Cite

show abstract

“…Cristinel et al reported increased TPOAb and TgAb levels in patients with autoimmune thyroid disease (AITD) and a history of chronic hepatitis C 1 month after SARS-CoV-2 infection 18…”

Section: Discussionmentioning

confidence: 99%

Painless thyroiditis incidentally diagnosed following SARS-CoV-2 infection

et al. 2022

View full text Add to dashboard Cite

A euthyroid woman in her 50s with papillary thyroid cancer and primary hyperparathyroidism was referred to our hospital for surgery. Her surgery was scheduled for 4 months later but was postponed because she was diagnosed with COVID-19. Five months after the first visit, she was admitted to our hospital to undergo the planned thyroid lobectomy and parathyroidectomy. Her blood tests on admission showed thyrotoxicosis, with negative thyroid-stimulating hormone receptor and thyroid-stimulating antibody. Notably, her anti-thyroglobulin antibody and anti-thyroid peroxidase antibody, which were originally negative, became positive after SARS-CoV-2 infection. She was diagnosed with painless thyroiditis. Her general condition and vital signs were stable, and the surgery was cautiously performed. Histopathological examination of the resected thyroid revealed papillary thyroid carcinoma, and the findings were consistent with painless thyroiditis. Her postoperative course was uneventful, and her thyroid function improved 2 weeks after the operation.

show abstract

“…In the thyroid, these receptors make it a suitable target for virus entry [ 1 , 6 – 8 ]. Alongside the ACE-2 receptor, the TMPRSS2 receptor also exists on the surface of the thyroid gland, which is a route for the virus entry into the cells [ 9 – 11 ]. The SARS-CoV-2 seems to directly affect the thyroid gland and also the thyroid gland concerning a systemic inflammatory reaction [ 7 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…Alongside the ACE-2 receptor, the TMPRSS2 receptor also exists on the surface of the thyroid gland, which is a route for the virus entry into the cells [ 9 – 11 ]. The SARS-CoV-2 seems to directly affect the thyroid gland and also the thyroid gland concerning a systemic inflammatory reaction [ 7 , 9 ]. An autopsy sample taken from the thyroid gland after death showed that COVID-19 directly infected the thyroid gland and caused the dysfunction of these glands [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The prevalence of thyroid disorders in COVID-19 patients: a systematic review and meta-analysis

Ashrafi,

Hatami,

Bidhendi-Yarandi

et al. 2024

BMC Endocr Disord

View full text Add to dashboard Cite

Objectives To conduct a systematic review and meta-analysis to evaluate the prevalence of thyroid disorders in COVID-19 patients. Data sources Scopus, PubMed, ISI Web of Science, and Google Scholar databases were used in this review. We also consider the results of grey literature. Study selections Cohort, cross-sectional, and case-control studies were included. Data extraction and synthesis The required data were extracted by the first author of the article and reviewed by the second author. The Pooled prevalence of outcomes of interest was applied using the meta-prop method with a pooled estimate after Freeman-Tukey Double Arcsine Transformation to stabilize the variances. Outcomes and measured The different thyroid disorders were the main outcomes of this study. The diseases include non-thyroidal illness syndrome, thyrotoxicosis, hypothyroidism, isolated elevated free T4, and isolated low free T4. Results Eight articles were included in our meta-analysis(Total participants: 1654). The pooled prevalence of events hypothyroidism, isolated elevated FT4, isolated low FT4, NTIS, and thyrotoxicosis were estimated (Pooled P = 3%, 95% CI:2–5%, I2: 78%), (Pooled P = 2%, 95% CI: 0–4%, I2: 66%), (Pooled P = 1%, 95% CI: 0–1%, I2: 0%), (Pooled P = 26%, 95% CI: 10–42%, I2: 98%), and (Pooled P = 10%, 95% CI: 4–16%, I2: 89%), respectively. Conclusion Thyroid dysfunction is common in COVID-19 patients, with a high prevalence of non-thyroidal illness syndrome (NTIS) and thyrotoxicosis. Our meta-analysis found a 26% prevalence of NTIS and a 10% prevalence of thyrotoxicosis. Systematic review registration PROSPERO CRD42022312601.

show abstract

A Prospective Observational Study of 42 Patients with COVID-19 infection and a History of Hepatitis C Virus Infection and Thyroid Disease with Follow-Up Thyroid Function and Autoantibody Testing

Cited by 5 publications

References 37 publications

COVID-19 and Laboratory Markers from Romanian Patients—A Narrative Review

COVID-19 and Laboratory Markers from Romanian Patients—A Narrative Review

Painless thyroiditis incidentally diagnosed following SARS-CoV-2 infection

The prevalence of thyroid disorders in COVID-19 patients: a systematic review and meta-analysis

Contact Info

Product

Resources

About