A prospective randomised controlled trial of octylcyanoacrylate tissue adhesive and standard suture for wound closure following breast surgery

Chen, Clement Th; Choi, Catherine Ly; Suen, Dacita; Kwong, Ava

doi:10.12809/hkmj154513

Cited by 4 publications

(8 citation statements)

References 10 publications

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“…23 Similarly, several recent trials have demonstrated that wound closure with OCA offers comparable scar cosmesis compared to repair with sutures. [24][25][26][27][28][29] In accord with our results, a 2014 Cochrane review and meta-analysis found that wound closure with tissue adhesives resulted in significantly more episodes of wound dehiscence than sutures. 30 Strengths of this study include its use of a validated scar assessment tool by blinded observers, a priori data analysis, and larger sample size relative to similar published studies.…”

Section: Discussionsupporting

confidence: 81%

Comparison of 2-Octylcyanoacrylate Versus 5-0 Fast-Absorbing Gut During Linear Wound Closures and the Effect on Wound Cosmesis

et al. 2020

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BACKGROUND Although the use of 2-octylcyanoacrylate (OCA) in cutaneous surgery offers increased efficiency, there is scant data comparing scar outcomes achieved with OCA versus 5-0 fast-absorbing gut suture (FG). OBJECTIVE To compare scar cosmesis achieved with OCA versus FG for surgical wound closure. MATERIALS AND METHODS A total of 44 patients with postoperative defects of at least 3 cm were included. Half of each wound was randomized to receive closure with either OCA or FG. At 3 months, patients and 2 blinded observers evaluated each scar using the Patient and Observer Scar Assessment Scale (POSAS). RESULTS The total observer POSAS score (mean [SD]) for the side repaired with OCA (12.3 [4.72]) and the side that received FG (11.6 [4.36]) did not differ significantly (p = .40). There was no significant difference in the total patient POSAS scores between closure with OCA (14.9 [8.67]) and FG (14.6 [8.90]) (p = .70). Based on observer POSAS scores, scar pigmentation was significantly worse on the scar half repaired with OCA (1.98 [0.91]) compared with FG (1.79 [0.80]) (p = .05). CONCLUSION With the exception of inferior scar pigmentation with OCA, there was no statistically significant difference in wound cosmesis after linear wound closure with OCA versus FG.

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Section: Discussionsupporting

confidence: 81%

Comparison of 2-Octylcyanoacrylate Versus 5-0 Fast-Absorbing Gut During Linear Wound Closures and the Effect on Wound Cosmesis

et al. 2020

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“…This feature was studied in randomized clinical trials like breast surgery for benign breast lump, repair of cutaneous and subcutaneous lacerations on children or repair of maxillofacial incisions. 123,126,127 Bioadhesives and sutures had comparable results in terms of cosmetic outcomes. Consequently, the choice of sutures or adhesives should not depend on this characteristic.…”

Section: Applicationsmentioning

confidence: 89%

“…Although sutures have been applied for centuries and are still used largely owing to their efficacy, ease of application and costs, some intricate applications have raised the need for additional sealing techniques. Rare complications related to the use of sutures include: granule formation, chronic wound changes, extended duration to achieve wound closure, extensive pain during application in case the patient is awake and the need to manually remove them after healing, in some cases 123,124 . Moreover, sutures may have limited uses with fragile tissues such as pulmonary parenchyma.…”

Section: Applicationsmentioning

confidence: 99%

“…First, the cosmetic outcomes are important characteristics compared in surgeries in which the appearance of the wound is substantial. This feature was studied in randomized clinical trials like breast surgery for benign breast lump, repair of cutaneous and subcutaneous lacerations on children or repair of maxillofacial incisions 123,126,127 . Bioadhesives and sutures had comparable results in terms of cosmetic outcomes.…”

Section: Applicationsmentioning

confidence: 99%

“…Rare complications related to the use of sutures include: granule formation, chronic wound changes, extended duration to achieve wound closure, extensive pain during application in case the patient is awake and the need to manually remove them after healing, in some cases. 123,124 Moreover, sutures may have limited uses with fragile tissues such as pulmonary parenchyma. Their utilities can be limited as in the case of trying to suture the posterior part of a vessel and on very small wounds.…”

Section: Applicationsmentioning

confidence: 99%

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Composition, host responses and clinical applications of bioadhesives

et al. 2022

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Bioadhesives are medical devices used to join or seal tissues that have been injured or incised. They have been classified into tissue adhesives, sealants, and hemostatic agents. Bioadhesives such as FloSeal ® , CoSeal ® , BioGlue ® , Evicel ® , Tisseel ® , Progel™ PALS, and TissuGlu ® have been commercialized and used in clinical setting. They can be formulated with natural or synthetic components or a combination of both including albumin, glutaraldehyde, chitosan, cyanoacrylate, fibrin and thrombin, gelatin, polyethylene glycol (PEG), along with urethanes. Each formulation has intrinsic properties and has been developed and validated for a specific application. This review article briefs the mechanisms by which bioadhesives forms adhesion to tissues and highlights the correlation between bioadhesives composition and their potential host responses. Furthermore, clinical applications of bioadhesives and their applicationdriven requirements are outlined.

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Cyanoacrylate Tissue Adhesives Compared With Sutures on Facial and Neck Wounds: A Meta‐analysis

Charoenlux,

Utoomprurkporn,

Seresirikachorn

2023

OTO Open

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ObjectiveTo compare the effectiveness between cyanoacrylate tissue adhesives (CTAs) and sutures for skin closure on the face and neck.Data SourcesEmbase, Medline, Scopus, Central, Web of Science.Review MethodsRandomized controlled trials comparing CTAs versus sutures for skin closure on the face and neck were included. Primary outcomes were cosmetic outcomes. Secondary outcomes were scar depth, scar width, pain, closure time, cost, and adverse events. Subgroup analyses were performed by wound locations, type of CTAs, type of sutures, age groups, and type of wounds. Physicians and patients evaluated the cosmetic outcomes.ResultsEighteen studies (1020 patients) were included. CTAs offered better cosmetic outcomes by Wound Registry Scale at ≤1 month (physician: mean difference [MD]: −1.50, 95% confidence interval, CI: −2.42 to −0.58). The cosmetic outcomes assessed by Visual Analog Scale were comparable at >1 to ≤3 months (physicians: standard mean difference [SMD], −0.01, 95% CI, −0.25 to 0.23, patients: SMD, −0.02, 95% CI, −0.84 to 0.79). The cosmetic outcomes by the Patient and Observer Scar Assessment Scale favored sutures at >3 to 12 months (physician: MD 4.26, 95% CI, 2.02‐6.50). Subgroup analyses revealed no differences. CTAs offered less scar depth, scar width, pain, closure time, and total cost of closure. Adverse events were similar.ConclusionBased on the wound healing process, the cosmetic outcomes exhibited a favorable inclination toward CTAs at <1 month while demonstrating comparable results between CTAs and sutures at >1 to ≤3 months. Subsequently, sutures exhibited superior cosmetic outcomes compared to CTAs at >3 to 12 months.

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A prospective randomised controlled trial of octylcyanoacrylate tissue adhesive and standard suture for wound closure following breast surgery

Cited by 4 publications

References 10 publications

Comparison of 2-Octylcyanoacrylate Versus 5-0 Fast-Absorbing Gut During Linear Wound Closures and the Effect on Wound Cosmesis

Comparison of 2-Octylcyanoacrylate Versus 5-0 Fast-Absorbing Gut During Linear Wound Closures and the Effect on Wound Cosmesis

Composition, host responses and clinical applications of bioadhesives

Cyanoacrylate Tissue Adhesives Compared With Sutures on Facial and Neck Wounds: A Meta‐analysis

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