A Prospective Randomized Comparative Trial Showing That Omeprazole Prevents Rebleeding in Patients With Bleeding Peptic Ulcer After Successful Endoscopic Therapy

Abstract

The use of omeprazole is more effective than cimetidine in increasing intragastric pH and reducing rebleeding episodes in patients with bleeding peptic ulcers after successful endoscopic therapy. This suggests that omeprazole should be used routinely after successful endoscopic therapy.

Effect of Intravenous Omeprazole on Recurrent Bleeding after Endoscopic Treatment of Bleeding Peptic Ulcers

“…Lin et al used thermocoagulation to treat 100 patients whose ulcers were actively bleeding or contained a nonbleeding visible vessel and then randomly assigned them to receive an infusion of either omeprazole or cimetidine. 11 Patients who received omeprazole had a significantly lower rate of recurrent bleeding than those who received cimetidine. In both the study by Villanueva et al and the study by Lin et al, the investigators were aware of the treatment assignments.…”

“…[7][8][9][10][11][12][13] Some of the studies did not use endoscopic treatment. 7,8 In some studies the numbers of patients were inadequate or the investigators were aware of the patients' treatment assignments.…”

“…7,8 In some studies the numbers of patients were inadequate or the investigators were aware of the patients' treatment assignments. [9][10][11] Two recent Scandinavian trials lacked discrete outcome variables. 12,13 Therefore, we conducted a randomized, double-blind, placebocontrolled study to assess whether the adjuvant use of a high-dose proton-pump inhibitor after endoscopic treatment of bleeding peptic ulcers would reduce the rate of recurrent bleeding.…”

Management of Acute Gastric Ulcer Bleeding

“…Proton pump inhibitors can increase the intra-gastric pH > 6.0 for 84 -99% of the day (Lin et al, 1998). Tolerance has not been reported and continuous infusion is superior to intermittent bolus administration (Brunner et al, 1996).…”

Intravenous Pantoprazole: A New Tool for Acutely Ill Patients Who Require Acid Suppression

“…Studies examining the use of intravenous omeprazole doses have had mixed results (75,89,(92)(93)(94)(95)(96)(97)(98)(99)(100)(101)(102)(103)(104). However, many of these trials used omeprazole dosing regimens that are thought to be suboptimal and will not be discussed further (75,89,(93)(94)(95)97,100).…”