A prospective, randomized comparison of pain, inflammatory response, and short-term outcomes between single port and laparoscopic cholecystectomy

Luna, Renato A.; Nogueira, Daniel B.; Varela, P.; Neto, Eduardo de O. Rodrigues; Norton, Maria Júlia R.; Ribeiro, Luciana do Carmo B.; Peixoto, Agatha M.; Mendonça, Yara L. de; Bendet, Isidro; Fiorelli, Rossano; Dolan, James P.

doi:10.1007/s00464-012-2589-5

Cited by 62 publications

(50 citation statements)

References 17 publications

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“…Several studies did not report on random sequence generation, allocation concealment or blinding, thereby making quality assessment a difficult task. High risk of bias was present in limited studies and regarded domains related to conflict of interest or funding sources [32,34,38], allocation concealment [17], attrition bias [17,25,27] and reporting bias [27].…”

Section: Risk Of Bias Within Studiesmentioning

confidence: 98%

“…Conversion was required in 6 patients of a single study, specifically 4 patients subjected to singleincision surgery with curved instruments and 2 conventional laparoscopic cholecystectomies [33]. Bile leak or subhepatic collection was reported in 5 studies [19,23,27,30,34], with an equal distribution among treatment arms (3 patients in each treatment group and 4 patients in the control group). The diagnosis was made through a drain tube in two studies which provided relevant information [27,34].…”

Section: Outcomes Of Individual Studiesmentioning

confidence: 99%

“…Ad hoc multiports were used in 13 studies. Curved instruments exclusively were used in 3 trials [27,33,39], and a combination of curved and linear instruments was applied in 7 [26,29,30,[34][35][36]40].…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

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Single-incision laparoscopic cholecystectomy with curved versus linear instruments assessed by systematic review and network meta-analysis of randomized trials

et al. 2015

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Single-incision laparoscopic cholecystectomy with curved instruments may be associated with an increased level of operative difficulty, as reflected by the need for auxiliary measures for exposure and increased operative time as compared to the use of linear instruments. Current instrumentation requires further improvement, tailored to the features of single-incision laparoscopic surgery (CRD42015015721).

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Section: Risk Of Bias Within Studiesmentioning

confidence: 98%

Section: Outcomes Of Individual Studiesmentioning

confidence: 99%

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Single-incision laparoscopic cholecystectomy with curved versus linear instruments assessed by systematic review and network meta-analysis of randomized trials

et al. 2015

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“…This applies to both gynecological and general surgical interventions [14,15,16]. Luna et al [17] compared single-incision surgery with conventional laparoscopy and found no difference in the CRP values. Most studies relate to gastrointestinal surgery.…”

Section: Discussionmentioning

confidence: 99%

Value of Clinical and Laboratory Inflammation Factors in the Postoperative Period after Laparoscopic Urogynecological Surgery

Noé

Anapolski²,

Soltész³

et al. 2014

Gynecol Obstet Invest

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Background/Aims: Leukocytes and C-reactive protein (CRP) levels are often used to detect infections. The aim of this study was to evaluate the diagnostic and screening validity of leukocytes and CRP levels as well as body temperature >38° C to predict infections after laparoscopic sacrocolpopexy. Methods: The study included 287 patients suffering from genital prolapse higher than POP-Q I. In addition to the sacrocolpopexy, a laparoscopic supracervical hysterectomy was performed in cases of preexisting uterus (n = 171). Leukocytes and CRP levels were analyzed preoperatively and 4 days after surgery. Early and late onset of infections was documented. Results: Urinary tract infection was identified as the most frequent early postoperative complication (11.4%). Early wound infections were found in 2.8% of the patients (8/287). Late onset of infections was found in 1% of patients (3/287). Areas under ROC curves were low for both leukocytes (0.52, 95% CI: 0.37-0.66) and CRP levels (0.60, 95% CI: 0.44-0.77). Conclusion: Our findings question the benefit of routine determination of leukocytes and CRP levels 4 days after surgery. The sensitivity and specificity of leukocytes and CRP levels are probably more significant after normalization of the initial tissue response (days 8-10).

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“…It has been clearly demonstrated in several studies 12,24,25 that IL-6 can be used as an inflammatory marker, since its levels are elevated early in the face of tissue damage. Therefore, the dosages of interleukin-6 and C-reactive protein have been used by several authors as a method of choice for the evaluation and comparison of the systemic inflammatory response in different groups 26,27 . Like IL-6, C-reactive protein can also be used as a marker of inflammation 2 .…”

Section: Sd: Standard Deviation; * Student T Test Comparison Of Meansmentioning

confidence: 99%

Comparative study of systemic early postoperative inflammatory response among elderly and non-elderly patients undergoing laparoscopic cholecystectomy

Fialho

Cunha-e-Silva

Santa-Maria

et al. 2018

Rev. Col. Bras. Cir.

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Objective: to evaluate and compare the early postoperative period systemic inflammatory response between elderly and non-elderly patients submitted to laparoscopic cholecystectomy, mainly performing a quantitative analysis of interleukin-6 (IL-6), a marker of inflammatory activity systemic. Methods: we compared a series of cases over a period of six months at the Gaffrée and Guinle University Hospital of the Federal University of the State of Rio de Janeiro, involving 60 patients submitted to elective laparoscopic cholecystectomy. We used non-probabilistic sampling for convenience, selecting, from the inclusion criteria, the first 30 patients aged 18-60 years, who comprised group I, and 30 patients with age equal to or greater than 60 years, who formed group II. Results: the 60 patients involved were followed for at least 30 days after surgery and there were no complications. There was no conversion to open surgery. The values of the medians found in the IL-6 dosages for the preoperative period, three hours after the procedure and 24 hours after surgery were, respectively, 3.1 vs. 4.7 pg/ml, 7.3 vs. 14.1 pg/ml and 4.4 vs 13.3 pg/ml. Conclusion: Elderly patients were more responsive to surgical trauma and had elevated IL-6 levels for a longer period than the non-elderly group.

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A prospective, randomized comparison of pain, inflammatory response, and short-term outcomes between single port and laparoscopic cholecystectomy

Abstract: Single-incision laparoscopic surgery does not significantly reduce systemic inflammatory response, postoperative pain, or analgesic use compared with LC.

Cited by 62 publications

References 17 publications

Single-incision laparoscopic cholecystectomy with curved versus linear instruments assessed by systematic review and network meta-analysis of randomized trials

Single-incision laparoscopic cholecystectomy with curved versus linear instruments assessed by systematic review and network meta-analysis of randomized trials

Value of Clinical and Laboratory Inflammation Factors in the Postoperative Period after Laparoscopic Urogynecological Surgery

Comparative study of systemic early postoperative inflammatory response among elderly and non-elderly patients undergoing laparoscopic cholecystectomy

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