A prospective randomized controlled trial of preimplantation genetic screening in the “good prognosis” patient

A review of, and commentary on, the ongoing second clinical introduction of preimplantation genetic screening (PGS) to routine IVF practice

“…It took above noted Dutch study [2] to stop to a degree this worldwide utilization of PGS. Other studies later reaffirmed the results reported by Mastenbroek et al [3][4][5][6]. Professional organizations followed by unequivocally concluding that PGS, at current practice levels, did not improve clinical IVF outcomes [7][8][9].…”

“…In such patients a day-3 embryo transfer may result in a viable pregnancy, while the same marginal embryo, cultured to days-5/6, may not survive prolonged culture. As a consequence, PGS#2, like PGS#1 before [2][3][4][5][6] in DOR patients may, therefore, actually reduce pregnancy chances.…”

Selecting a Single Embryo for Transfer after In-vitro Fertilization: A Translational Medicine Perspective

“…Contrary to expectation, results from numerous studies did not show that the PGS-FISH was capable of improving live birth rates in patients of advanced maternal age, with recurrent implantation failure or repeated pregnancy loss [35][36][37][38][39][40][41][42][43][44][45][46]. This is because FISH screening does not make it possible to test for all 23 chromosome pairs.…”

IVF/ICSI with or without preimplantation genetic screening for aneuploidy in couples without genetic disorders: a systematic review and meta-analysis

“…Ten prospective, randomized, parallel-group, controlled studies evaluating PGS for aneuploidies in IVF/ICSI versus IVF/ICSI met the inclusion criteria [10][11][12][13][14][25][26][27][28][29][30].…”