A prospective randomized double blind study to compare dexmedetomidine and midazolam in ear nose and throat surgery for monitored anesthesia care

Sociodemographic Status of Propofol and Dexmedetomidine as an Agent of Conscious Sedation in Patients Undergoing Tympanoplasty

“…It was observed that Among group I, 25(83.3%) needs no rescue sedation, and only 5 (16.7 %)patients required rescue sedation with the anaesthesia technique .On the contrary 24(80%) patients not required rescue sedation and only 6(20%) patients required rescue sedation in group II respectively. The total number of rescue doses of sedatives was lesser in dexmedetomidine group consistent with the findings of [7].…”

“…It can be used in perioperative period as an analgesic adjunct. Lower heart rate and mean arterial pressure provides better operative field for microscopic surgery [7]. It decreases bleeding when bloodless surgical field required.…”

Efficacy of dexmedetomidine on perioperative morbidity during nasal surgery: A meta‐analysis

“…In contrast, although intraoperative bradycardia and hypotension were transient and reversed following medication without significant sequelae, the incidences of these adverse effects tended to be higher in the dexmedetomidine group than in the control group (general anesthesia and other sedatives under MAC) despite no statistical insignificance. For example, although Dogan et al reported significant bradycardia and hypotension were not observed in both the dexmedetomidine and general anesthesia groups, Delmade et al showed that four patients in dexmedetomidine group had bradycardia compared to none in other sedatives group, and Karaaslan et al presented that the prevalence of bradycardia (4 patients) and hypotension (5 patients) in the dexmedetomidine group was higher compared with that in other sedatives group (0 and 1 patient, respectively). Given these results, we could recommend that it is necessary to carefully monitor patient conditions and explain the risks to the patients beforehand.…”

“…Data from eligible studies were extracted using standardized forms and independently checked by the two investigators. Outcomes analyzed were intra‐ and postoperative pain; postoperative (24 hours) analgesic requirements (dose of postoperative opioids or nonopioid analgesics); occurrence of postoperative nausea and vomiting (PONV) (incidence or percentage of patients); intraoperative hypotension; intraoperative bradycardia; intraoperative desaturation; occurrence of patient satisfaction (incidence or percentage of patients); and operative blood loss . In the enrolled study for analgesics, one study used diclofenac (nonsteroidal antiinflammatory drug) as the additional analgesic, and the remaining studies used opioids such as tramadol and fentanyl as the additional analgesics.…”

“…Nasal surgeries such as septoplasty and endoscopic sinus surgery are relatively superficial and noninvasive and can be performed under local anesthesia or local anesthesia with sedation in cooperative and well‐counseled patients . Local anesthesia has the advantage of not requiring airway penetration or mechanical ventilation, together with fewer cases of postoperative nausea/vomiting and headache .…”