A prospective, randomized, double blind, placebo controlled clinical trial to study efficacy and safety of benzydamine 0.15% gargles in prevention of postoperative sore throat

Gaikwad, Smita M; Rupwate, Kanchan; Tendolkar, Bharati A

doi:10.18203/2320-6012.ijrms20161825

Cited by 4 publications

(5 citation statements)

References 15 publications

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“…In experiment involving fat cells in vitro, benzydamine hydrochloride might increase the formation of cyclic 3′,5′-AMP which affects the activity of intracellular cation. This effect may originate from the activity of local anesthetics held by benzydamine hydrochloride [8]. In this study, desaturation occurred in the control group while hypotension occurred in both groups.…”

Section: Discussionmentioning

confidence: 49%

“…The diffusion depth of topical administration is not exactly understood. However, some studies stated that most of it would be more concentrated in the tissue surface compared to when administered systemically [8,9]. The local anesthesia effect of benzydamine hydrochloride might be the cause of significant decrease of cumulative propofol consumption in this study.…”

Section: Discussionmentioning

confidence: 58%

“…Benzydamine hydrochloride has been used in years to reduce the mucosal inflammation due to radiotherapy radiation and to reduce the incidence of sore throat postprocedure in patients undergoing general anaesthesia with endotracheal intubation or laryngeal mask airway devices [7,8]. The agent was used as a mouthwash before the procedure began.…”

Section: Discussionmentioning

confidence: 99%

“…The agent was used as a mouthwash before the procedure began. Gargling is effective in distributing the agent into oropharyngeal area, posterior pharyngeal wall, anterior epiglottis area, and uvula [8,9]. Thus, those areas would be covered by the agent and it reduced the sore throat in patients undergoing the procedure.…”

Section: Discussionmentioning

confidence: 99%

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Effectivity of benzydamine hydrochloride gargle to reduce propofol consumption in endoscopic retrograde cholangiopancreatography procedure: a randomized controlled trial

et al. 2020

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Background: Endoscopic Retrograde Cholangiopancreatography (ERCP) is a complex endoscopic procedure that requires moderate to deep sedation. Propofol is the sedative agent of choice for sedation in ERCP due to its fast distribution and fast elimination time without a cumulative effect after infusion, resulting in shorter recovery time. Benzydamine hydrochloride is a topical non-steroidal anti-inflammatory drug that has analgesic, local anesthetic, and anti-inflammatory effects that have been known to be effective in reducing postoperative sore throat. Combination of propofol and topical analgesic may provide adequate sedation and reduce propofol consumption. This study aimed to determine the effectivity of benzydamine hydrochloride gargling in reducing propofol consumption in the ERCP procedure. Methods: This study was a single-blind randomized controlled trial for patients undergoing ERCP procedures at Cipto Mangunkusumo Hospital from August to September 2018. A total of 72 subjects were recruited consecutively and randomly assigned into two groups. The first group received 15 mL of 0.15% benzydamine hydrochloride mouthwash prior to the procedure, whereas the second group received 15 mL of water mouthwash. Additional propofol was administered when patient moved or Ramsay Sedation Scale rose above 4. Cumulative propofol consumption per kg body weight per minute and incidence of postoperative sore throat were recorded in each group. Incidence of desaturation, postoperative nausea vomitting, and dysphagia were also recorded. Data analysis was performed with Statistical Package for the Social Sciences.

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Effectivity of benzydamine hydrochloride gargle to reduce propofol consumption in endoscopic retrograde cholangiopancreatography procedure: a randomized controlled trial

et al. 2020

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“…19 A prospective randomized double-blind comparative study also confirmed the effectiveness of a gargle with benzydamine HCl for 30 seconds before undergoing surgery under general anaesthesia in alleviating the POST, the severity of cough and the voice hoarseness vs. a control group treated with placebo. 20 Of note, benzydamine HCl gargle proved to be effective in reducing the consumption of propofol, an agent of choice used for sedation during endoscopic retrograde cholangiopancreatography. The combination of propofol and benzydamine HCl mouthwash reduced POST, cumulative propofol consumption/min/kg body weight and desaturation vs. the control group that received propofol and water mouthwash.…”

Section: The Mechanisms Of Action Of Benzydamine Hclmentioning

confidence: 99%

Benzydamine hydrochloride: an overview on a well-established drug with news in mechanisms of action

Ferrer-Montiel

2024

F1000Res

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Pain and inflammation are the consequences of sore throat, dental and oral procedures, infections, ulcers and head and neck chemotherapy/radiotherapy, and their management is of fundamental importance to avoid distress in patients. Benzydamine hydrochloride (HCl) is a topical indolic nonsteroidal anti-inflammatory drug, endowed with analgesic and anesthetic activity, and with antimicrobial (including both gram-positive and gram-negative bacteria) and antifungal properties (targeting Candida albicans and non-albicans strains), used in odontostomatology, otorhinolaryngology, and gynecology for its properties. This molecule has a lipophilic nature, showing high affinity with cell membranes and exhibiting membrane stabilization properties, resulting in local anesthesia, an effect related also to the interaction of the drug with cationic channels. In addition, benzydamine HCl is able to inhibit the production of pro-inflammatory cytokines, with consequent analgesia. Moreover, benzydamine HCl is able to inhibit leukocyte-endothelial interactions and platelet aggregation. Unlike other non-steroidal anti-inflammatory drugs, benzydamine HCl does not inhibit cyclooxygenase or lipoxygenase. Here we review the most updated clinical data available on benzydamine HCl local application as spray, mouthwash or gargling and evidence of its effectiveness in inflammatory and/or septic conditions in the otorhinolaryngology and odontostomatology settings, with particular reference to sore throat, oral inflammation, dental plaque, tonsillitis/tonsillectomy and chemo- or radiotherapy-induced oral mucositis. Novel formulations for oral administration of benzydamine HCl are also reviewed, including in situ gelling formulations to be sprayed onto the damaged oral mucosa. Finally, novel data on the potential role of benzydamine HCl in nociceptor excitability are introduced.

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Efficacy of topical agents for prevention of postoperative sore throat after single lumen tracheal intubation: a Bayesian network meta-analysis

Singh

Makkar

Cappellani

et al. 2020

Can J Anesth/J Can Anesth

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A prospective, randomized, double blind, placebo controlled clinical trial to study efficacy and safety of benzydamine 0.15% gargles in prevention of postoperative sore throat

Cited by 4 publications

References 15 publications

Effectivity of benzydamine hydrochloride gargle to reduce propofol consumption in endoscopic retrograde cholangiopancreatography procedure: a randomized controlled trial

Effectivity of benzydamine hydrochloride gargle to reduce propofol consumption in endoscopic retrograde cholangiopancreatography procedure: a randomized controlled trial

Benzydamine hydrochloride: an overview on a well-established drug with news in mechanisms of action

Efficacy of topical agents for prevention of postoperative sore throat after single lumen tracheal intubation: a Bayesian network meta-analysis

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